With Week 16 of the NFL season upon us, the excitement is at its peak as teams strive for playoff spots. The Chiefs, Bills and Texans have already secured their places as AFC division champions, but the NFC is still up for grabs, promising an exciting finish to the regular season.

There are many interesting storylines, including Patrick Mahomes' ankle injury affecting the Chiefs' Super Bowl hopes and the rising Buccaneers and Rams emerging as potential surprise contenders. At the same time, teams like the Broncos and Commanders are fighting hard for wins, and the battle for the AFC North title is intense with only three weeks remaining.

With half of the playoff spots still undecided, every game is crucial. Let’s explore the matchups and highlight the best NFL Week 16 picks, both straight up and against the spread, for what is sure to be another thrilling week of football!

 

 

 

NFL Week 16 Picks Straight Up For All 16 Games At Bet365 Sportsbook

I’ll analyze a couple of games in particular and offer my NFL Week 16 predictions against the spread as usual.

Before diving into the details though, I’ll share my straight-up winners for each game to offer some further insight:

Partnering with Bet365 Sportsbook this week, let’s get right into a few of my spread predictions for NFL Week 16 picks entering this pivotal moment of the season!

 

 

 

NFL Week 16 Early Spread Picks & Predictions

Cardinals vs. Panthers Spread Pick: Sunday, December 22nd

They’ve faced some tough losses and let me down a week ago, but Carolina has shown improvement lately, losing narrowly to strong teams like the Buccaneers and Chiefs. Their ability to compete, even when they don't win, is important for underdogs.

On the other hand, the Cardinals have been inconsistent, with a mix of great wins and confusing losses. While Arizona has one of the best rushing attacks, their passing game is average, ranking 21st in yards per game. Carolina's defense, despite some struggles, has had good moments, especially against the pass, where they rank 12th in yards allowed per game.

Playing at home should help the Panthers, as they usually perform better in Charlotte. Considering Arizona's issues in close games and Carolina's recent efforts against tough opponents, this matchup looks like it will be closely contested, making Panthers +4.5 (-110 at Bet365) the first of our NFL Week 16 picks.

 

 

 

Lions vs. Bears Spread Pick: Sunday, December 22nd

Look for the Bears to cover the +6.5 spread (-110 at Bet365) at home against the Lions to close out our NFL Week 16 predictions. Chicago put up a good fight against Detroit on Thanksgiving, losing narrowly 23-20 as underdogs. This game showed that the Bears can compete with the Lions' powerful offense, even away from home.

Now back at Soldier Field, the home advantage could be crucial in keeping the game close. The Lions are dealing with several injuries, impacting their defense and offense lately. Although Detroit has the highest-scoring offense in the NFL (32.8 PPG), their defense has been shaky, allowing 42 points to the Bills in Week 15.

For Chicago, the defense has improved in the red zone, ranking third in touchdown percentage allowed, which may help limit Detroit’s scoring chances. With Detroit's defensive issues and injury problems, the Bears should have enough chances to stay competitive and cover the spread.

 

 

 

How To Bet On Our Free Picks At Bet365 Sportsbook & Win $1,000 In Bonus Bets

You have the opportunity to select your own bonus when you register at Bet365 Sportsbook through our links! Let's begin with the bet-and-get option. If you place a bet of $5 or more on any event, such as our NFL Week 16 picks, you will earn $150 in bonus bets, regardless of whether your bet wins or loses! Alternatively, you may opt for the $1,000 first-bet protection.

For this choice, simply place a bet of $10 or more, with the potential to wager up to $1,000. You will receive either your standard payout or a complete refund in the form of bonus bets. When you're ready to select the ideal Bet365 bonus code, just click this link to register before this week’s action!

 

 

 

NFL Week 16 Odds For All 16 Games Provided By Bet365 Sportsbook

My NFL Week 16 picks are now out of the way, and I'm excited to share the spread odds for each game. We've continued our focus on Bet365 Sportsbook:

  • Broncos +2.5 (+100) vs. Chargers -2.5 (-120)
  • Texans +3 (-110) vs. Chiefs -3 (-110)
  • Steelers +6.5 (-115) vs. Ravens -6.5 (-105)
  • Giants +9 (-110) vs. Falcons -9 (-110)
  • Lions -6.5 (-110) vs. Bears +6.5 (-110)
  • Cardinals -4.5 (-110) vs. Panthers +4.5 (-110)
  • Rams -3 (-120) vs. Jets +3 (+100)
  • Eagles -3.5 (-110) vs. Commanders +3.5 (-110)
  • Browns +7.5 (-110) vs. Bengals -7.5 (-110)
  • Titans +3.5 (-110) vs. Colts -3.5 (-110)
  • Vikings -3 (-110) vs. Seahawks +3 (-110)
  • Patriots +14 (-110) vs. Bills -14 (-110)
  • Jaguars +1 (-110) vs. Raiders -1 (-110)
  • 49ers +1 (-110) vs. Dolphins -1 (-110)
  • Buccaneers -4 (-105) vs. Cowboys +4 (-115)
  • Saints +14 (-105) vs. Packers -14 (-115)

If you're thinking about betting on the NFL Week 16 odds or exploring other betting opportunities, I strongly suggest creating a new Bet365 account using our links, which could give you an extra $1,000 in bonus bets!