NFL Week 13 Picks Straight Up, Odds For All 16 Games & Spread Picks
With Week 12 now in the rearview mirror, it’s becoming more and more evident with every slate that passes which teams are legit Super Bowl contenders and which ones aren’t.
The Lions and Eagles appear to be the cream of the crop in the NFC, while the Chiefs, Ravens and Bills figure to be the team coming out of the AFC. Things can change though – and, in this league, fast – so it’ll be interesting to see how the rest of the regular season shakes out.
Coming up is arguably the best week all season: Thanksgiving! Not only are we bye-less, but we get three games on Thanksgiving Day followed by one of Black Friday before the usual on Sunday, plus Monday Night. Sounds like a great time to make some NFL Week 13 picks!
NFL Week 13 Picks Straight Up For All 16 Games At BetMGM Sportsbook
With a complete slate of 16 exciting games ahead, let's dive into the matchups and I'll provide my NFL Week 13 predictions. As usual, I'll highlight the straight up winners for your convenience:
- Chicago Bears vs. Detroit Lions (Thanksgiving)
- New York Giants vs. Dallas Cowboys (Thanksgiving)
- Miami Dolphins vs. Green Bay Packers (Thanksgiving)
- Las Vegas Raiders vs. Kansas City Chiefs (Black Friday)
- Houston Texans vs. Jacksonville Jaguars
- Indianapolis Colts vs. New England Patriots
- Los Angeles Chargers vs. Atlanta Falcons
- Seattle Seahawks vs. New York Jets
- Tennessee Titans vs. Washington Commanders
- Pittsburgh Steelers vs. Cincinnati Bengals
- Arizona Cardinals vs. Minnesota Vikings
- Los Angeles Rams vs. New Orleans Saints
- Tampa Bay Buccaneers vs. Carolina Panthers
- Philadelphia Eagles vs. Baltimore Ravens
- San Francisco 49ers vs. Buffalo Bills (SNF)
- Cleveland Browns vs. Denver Broncos (MNF)
We'll be placing our NFL Week 13 bets at BetMGM Sportsbook. Get ready for an action-packed week!
NFL Week 13 Early Spread Picks & Predictions
Colts vs. Patriots Spread Pick: Sunday, December 1st
I’m starting my NFL Week 13 picks with a home underdog. With a +2.5-point spread and +100 odds, the Colts vs. Patriots game offers a great chance for value. The Patriots' defense plays a key role in this ordeal.
They’ll be up against a young quarterback in Anthony Richardson, who is still adjusting to the NFL. This New England defensive unit could take advantage of Richardson's lack of experience, creating turnovers and disrupting the Colts' offense.
On the offensive side, rookie quarterback Drake Maye has shown potential. Although he lacks the experience, Maye's calmness and accuracy suggest he could be a bright star. If the Patriots' offensive line protects him well, Maye could very well lead the team to victory.
Overall, the mix of a solid defense, an exciting young quarterback and a favorable spread makes the Patriots an attractive option to cover the spread and possibly win against the Colts.
Cardinals vs. Vikings Spread Pick: Sunday, December 1st
Another underdog is on tap for my NFL Week 13 picks, but this time one that’s playing on the road. The Cardinals may be seen as underdogs, but they present a compelling case to cover the 3.5-point spread (-110 at BetMGM) against the Vikings in Week 13.
Kyler Murray has proven to be one of the most electrifying dual-threat quarterbacks in the league, propelling the Cardinals' offense to impressive new levels. His knack for making plays both through the air and on the ground provides the Cardinals with a distinct edge.
Although the Vikings boast talent, their performance hasn't always matched their record; they've often found themselves in nail-biting finishes. Their defense, while competent, has its vulnerabilities. With Murray at the helm, the Cardinals are well-positioned to take advantage of any gaps in the Vikings' defense, potentially keeping the game tight or even winning outright.
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NFL Week 13 Odds For All 16 Games Provided By BetMGM Sportsbook
Now that I've shared my NFL Week 13 picks, I want to let you know that we've compiled the spread odds for each game, thanks to BetMGM Sportsbook:
- Bears +10 (-105) vs. Lions -10 (-115)
- Giants +3.5 (-110) vs. Cowboys -3.5 (110)
- Dolphins +3 (+100) vs. Packers -3 (-120)
- Raiders +12.5 (-105) vs. Chiefs -12.5 (-115)
- Texans -5 (-110) vs. Jaguars +5 (-110)
- Colts -2.5 (-120) vs. Patriots +2.5 (+100)
- Chargers -1.5 (-110) vs. Falcons +1.5 (-110)
- Seahawks -2 (-110) vs. Jets +2 (-110)
- Titans +5.5 (-110) vs. Commanders -5.5 (-110)
- Steelers +3 (-115) vs. Bengals -3 (-105)
- Cardinals +3.5 (-110) vs. Vikings -3.5 (-110)
- Rams -3 (-105) vs. Saints +3 (-115)
- Buccaneers -6 (-110) vs. Panthers +6 (-110)
- Eagles +3 (-115) vs. Ravens -3 (-105)
- 49ers +7 (-115) vs. Bills -3 (-105)
- Browns +5.5 (-110) vs. Broncos -5.5 (-110)
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Player News
Jaguars signed TE Quintin Morris, formerly of the Bills, to a one-year contract.
Morris is purely a blocking tight end. He caught just 15 passes during his three years with the Bills, though he did manage to find the end zone three times. Morris will back up Brenton Strange in Jacksonville.
Ravens signed Derrick Henry to a two-year, $30 million contract extension.
Per NFL Network’s Ian Rapoport, Henry is the first running back over the age of 30 to make $15 million per year. Henry hit the open market at the peak of the “running backs don’t matter” discourse and signed a measly two-year, $16 million deal with the Ravens last offseason. He spent the 2025 season stuffing nerds in lockers with 1,921 yards and 16 touchdowns on 325 attempts. The monstrous season more than earned him a raise and the Ravens knew the assignment. Rapoport noted that Henry wants to finish his career in Baltimore and the extension will give him the opportunity to do so.
ESPN’s Rob Demovsky reports Packers C Elgton Jenkins is skipping offseason workouts for contract reasons.
Jenkins is being moved to center ahead of the 2025 season. He is a left guard by trade but has also spent time at both tackle spots during his six years in Green Bay. The Packers signed him to a four-year, $68 million extension in 2022 that runs through 2026. The deal initially made him a highly-paid guard. It now has him as one of the league’s most expensive centers. The Packers could save $20 million by cutting Jenkins next offseason, something they would likely do unless Jenkins is immediately one of the league’s best centers. Jenkins, in turn, is almost certainly looking to up his guarantees on the final two years of the contract. Though, as Demovsky points out, the Packers rarely adjust contracts this far from their expiration, Jenkins could be the exception to the rule.
Dak Prescott said George Pickens is “more than a 50-50 catcher.”
Prescott in a Wednesday morning radio interview was effusive in his praise of Pickens, who was traded last week from the Steelers to Dallas in exchange for draft compensation. “You put the ball anywhere in his vicinity, very strong hands,” Prescott said of Pickens. “He’s more than a 50-50 catcher. ... I’m excited for him. I know that we need some help at that position.” Pickens, 24, has 2,841 receiving yards and 12 touchdowns over three NFL seasons and is widely expected to see more single coverage in Dallas than he did as the unquestioned No. 1 wideout in Pittsburgh. Opposing coverage units won’t be able to shade safeties toward his side of the field with CeeDee Lamb threatening the middle of the field. Pickens shapes up as a volatile WR2/3 in 2025.
The Lions will play the Vikings on Christmas Day.
The Week 17 matchup between longtime NFC North rivals will be available exclusively on Netflix. Coming off a devastating Divisional Round loss to Washington last January, the Lions will be prominently featured by the league in 2025. Jared Goff and the Lions beat Minnesota twice during the 2024 regular season: A 31-29 Week 7 victory in Minnesota and a 31-9 Week 18 drubbing in Detroit. Goff combined to throw for 511 yards, three touchdowns, and no interceptions in those games. Justin Jefferson, meanwhile, was limited to ten catches for 131 yards and a touchdown in the Vikings’ 2024 games against Detroit.
The Eagles will face the Chiefs in Week 2.
The NFL’s trickle of 2025 schedule news includes a Super Bowl rematch in Kansas City, where Patrick Mahomes and company will look for a little revenge after getting bulldozed by the Eagles in Super Bowl LIX, 40-22. Philadelphia’s elite defense held Mahomes to a mere 226 yards on 32 pass attempts, with much of that production coming in fourth quarter garbage time. Jalen Hurts threw of two scores and ran in another as Saquon Barkley was held in check to the tune of 57 scoreless yards on 23 carries. If the Chiefs are to get back at the Eagles in Week 2, they’ll have to do a far better job of protecting Mahomes.