NFL Week 6 Picks Straight Up, Odds For All 14 Games & Spread Picks

Just like that, we’ve already reached Week 6 of the NFL season! Byes began taking place a week ago, so once again, we have 14 games on the slate.
On paper, many of these matchups should be competitive, but it is the NFL – we all just watched both the Cardinals and Giants go into hostile environments in Week 5 (49ers, Seahawks) and come away with unexpected victories.
Still, I’m confident in my reads here with my NFL Week 6 picks, and I’m excited to share them with you!
NFL Week 6 Picks Straight Up For All 14 Games At FanDuel Sportsbook
As I already mentioned, we have a total of 14 games lined up for this week’s slate. What better way to deliver my NFL Week 6 picks than by making a prediction on every single matchup?
That’s just what I did below, as each bolded team is the one I’m siding with:
- San Francisco 49ers vs. Seattle Seahawks (TNF)
- Jacksonville Jaguars vs. Chicago Bears
- Tampa Bay Buccaneers vs. New Orleans Saints
- Washington Commanders vs. Baltimore Ravens
- Arizona Cardinals vs. Green Bay Packers
- Indianapolis Colts vs. Tennessee Titans
- Houston Texans vs. New England Patriots
- Cleveland Browns vs. Philadelphia Eagles
- Los Angeles Chargers vs. Denver Broncos
- Pittsburgh Steelers vs. Las Vegas Raiders
- Atlanta Falcons vs. Carolina Panthers
- Detroit Lions vs. Dallas Cowboys
- Cincinnati Bengals vs. New York Giants (SNF)
- Buffalo Bills vs. New York Jets (MNF)
All of my NFL Week 6 picks are being made at FanDuel Sportsbook!
NFL Week 6 Early Spread Picks & Predictions
Buccaneers vs. Saints Spread Pick: Sunday, October 13th
Even though it’s in NOLA, the Buccaneers are in a strong position to cover the 3.5-point spread against the Saints in Week 6, mainly because of the quarterback challenges facing New Orleans.
With Derek Carr's oblique injury likely keeping him off the field for multiple games, the Saints will be without their starting QB, significantly impacting their offensive capabilities. Tampa Bay's defense is more set up to stop the run, meaning they’re set to capitalize on this weakness.
Meanwhile, the Bucs' offense has been performing well, with Baker Mayfield hitting his stride to lead a top-10 scoring unit. Look for Tampa Bay to dictate the game’s tempo and exploit the Saints’ compromised offense to successfully cover the spread.
Lions vs. Cowboys Spread Pick: Sunday, October 13th
How about another road favorite? I love a narrative, and Detroit will surely be out for vengeance after their still-confusing loss to Dallas last season. The Cowboys are coming off a victory against the Steelers, but that Pittsburgh offense is dreadful.
The Lions, on the other hand, boast one of the best units in all the league on that side of the ball. I think the Cowboys have a shot here because of Detroit’s weak pass defense, but they’ll need their offense to be on point, something it has struggled with so far this season.
At the end of the day, the Lions are the much better team in this one and I don’t see them having too much trouble covering.
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NFL Week 6 Odds For All 14 Games Provided By FanDuel Sportsbook, October 2024
With my NFL Week 6 picks out of the way, I’ll leave you with the spread odds for each matchup via FanDuel Sportsbook:
- 49ers -3.5 (-105) vs. Seahawks +3.5 (-115)
- Jaguars +1.5 (-105) vs. Bears -1.5 (-115)
- Buccaneers -3.5 (-105) vs. Saints +3.5 (-115)
- Commanders +6.5 (-108) vs. Ravens -6.5 (-112)
- Cardinals +5.5 (-114) vs. Packers -5.5 (-106)
- Colts -1.5 (-105) vs. Titans +1.5 (-115)
- Texans -7 (-110) vs. Patriots +7 (-110)
- Browns +8.5 (-110) vs. Eagles -8.5 (-110)
- Chargers -3 (-105) vs. Broncos +3 (-115)
- Steelers -3 (-102) vs. Raiders +3 (-120)
- Falcons -6.5 (-102) vs. Panthers +6.5 (-120)
- Lions -3 (-115) vs. Cowboys +3 (-105)
- Bengals -3.5 (-104) vs. Giants +3.5 (-118)
- Bills -2.5 (-112) vs. Jets +2.5 (-108)
Remember, you can place a bet on any of the NFL Week 6 odds above, or any betting market for that matter, and earn an extra $300 in bonus bets if you win! All it takes is you registering through us to create your new account at FanDuel!
Player News
Ravens signed Derrick Henry to a two-year, $30 million contract extension.
Per NFL Network’s Ian Rapoport, Henry is the first running back over the age of 30 to make $15 million per year. Henry hit the open market at the peak of the “running backs don’t matter” discourse and signed a measly two-year, $16 million deal with the Ravens last offseason. He spent the 2025 season stuffing nerds in lockers with 1,921 yards and 16 touchdowns on 325 attempts. The monstrous season more than earned him a raise and the Ravens knew the assignment. Rapoport noted that Henry wants to finish his career in Baltimore and the extension will give him the opportunity to do so.
ESPN’s Rob Demovsky reports Packers C Elgton Jenkins is skipping offseason workouts for contract reasons.
Jenkins is being moved to center ahead of the 2025 season. He is a left guard by trade but has also spent time at both tackle spots during his six years in Green Bay. The Packers signed him to a four-year, $68 million extension in 2022 that runs through 2026. The deal initially made him a highly-paid guard. It now has him as one of the league’s most expensive centers. The Packers could save $20 million by cutting Jenkins next offseason, something they would likely do unless Jenkins is immediately one of the league’s best centers. Jenkins, in turn, is almost certainly looking to up his guarantees on the final two years of the contract. Though, as Demovsky points out, the Packers rarely adjust contracts this far from their expiration, Jenkins could be the exception to the rule.
Dak Prescott said George Pickens is “more than a 50-50 catcher.”
Prescott in a Wednesday morning radio interview was effusive in his praise of Pickens, who was traded last week from the Steelers to Dallas in exchange for draft compensation. “You put the ball anywhere in his vicinity, very strong hands,” Prescott said of Pickens. “He’s more than a 50-50 catcher. ... I’m excited for him. I know that we need some help at that position.” Pickens, 24, has 2,841 receiving yards and 12 touchdowns over three NFL seasons and is widely expected to see more single coverage in Dallas than he did as the unquestioned No. 1 wideout in Pittsburgh. Opposing coverage units won’t be able to shade safeties toward his side of the field with CeeDee Lamb threatening the middle of the field. Pickens shapes up as a volatile WR2/3 in 2025.
The Lions will play the Vikings on Christmas Day.
The Week 17 matchup between longtime NFC North rivals will be available exclusively on Netflix. Coming off a devastating Divisional Round loss to Washington last January, the Lions will be prominently featured by the league in 2025. Jared Goff and the Lions beat Minnesota twice during the 2024 regular season: A 31-29 Week 7 victory in Minnesota and a 31-9 Week 18 drubbing in Detroit. Goff combined to throw for 511 yards, three touchdowns, and no interceptions in those games. Justin Jefferson, meanwhile, was limited to ten catches for 131 yards and a touchdown in the Vikings’ 2024 games against Detroit.
The Eagles will face the Chiefs in Week 2.
The NFL’s trickle of 2025 schedule news includes a Super Bowl rematch in Kansas City, where Patrick Mahomes and company will look for a little revenge after getting bulldozed by the Eagles in Super Bowl LIX, 40-22. Philadelphia’s elite defense held Mahomes to a mere 226 yards on 32 pass attempts, with much of that production coming in fourth quarter garbage time. Jalen Hurts threw of two scores and ran in another as Saquon Barkley was held in check to the tune of 57 scoreless yards on 23 carries. If the Chiefs are to get back at the Eagles in Week 2, they’ll have to do a far better job of protecting Mahomes.
The Athletic’s Mike DeFabo believes RB Kaleb Johnson is a “schematic fit” for the Steelers offense.
Johnson, a third-round draft pick who last month was listed as a co-starter alongside Jaylen Warren on the Pittsburgh depth chart, was a hyper-productive back in Iowa’s zone-based rushing scheme, a system used frequently in Arthur Smith’s run-first offense. Only three college running backs in 2024 logged more zone rushes than Johnson. Johnson’s goals in offseason practices, according to DeFabo, “are to learn the playbook and earn the coaching staff’s trust with the hope of becoming an ‘every-down back’ sooner rather than later.” That might require Johnson to improve his pass blocking. The rookie said he’s worked on that with Warren — one of the best blocking backs in the NFL — in recent days.