Jaguars vs. Texans Predictions, Picks & Odds: NFL Week 4, Sunday 9/29

After a couple of years of things looking like the Jacksonville Jaguars were going to start taking over the AFC South for a while, the Houston Texans have swooped in and had something to say about that. Even still, these division rivalries never seem to disappoint, which is why we’re here to provide you with our best Jaguars vs. Texans predictions.
Also, even if you already have Jaguars vs. Texans picks in mind, you’ll still want to check out everything below, as we have a generous $1,000 Caesars Sportsbook sign up promo for you as well!
Jaguars vs. Texans Predictions For NFL Week 4, Sunday 9/29
After making QB Trevor Lawrence the highest-paid player in the NFL on an annual basis (at the time) this offseason, it’s safe to say that the Jags were fully bought in. With his college mate RB Travis Etienne by his side, optimism in Jacksonville couldn’t have been higher.
Well, an 0-3 start has turned the tide, while the Texans are finding ways to use their abundance of weapons. However, don’t get it twisted - it hasn’t been perfect in Houston either. They’re coming off a 34-7 beatdown by the hands of the Minnesota Vikings, so this division rivalry is something both teams need in a big way.
Jacksonville Jaguars: Trying To Find Positives
It may be difficult to find things for the Jags to hang their hat on after their most recent loss, which was broadcast for the entire world to see on Monday Night Football. The 47-10 thrashing was as bad as it gets, but they can at least say that the Buffalo Bills may be the best team in the entire NFL.
As for their other losses, the first was against another AFC East team - the Miami Dolphins - which was a game that they controlled for quite a bit. The other was against the Cleveland Browns, which was one where they at least held them to just 18 points. Again, things aren’t easy in northern Florida, but these are things that the Jags need to focus on.
Houston Texans: Taking Control Of The AFC South
With the Texans snagging RB Joe Mixon and WR Stefon Diggs this offseason, expectations were that they would build on last year’s impressive 10-7 campaign. While it hasn’t been perfect, this matchup with the Jags is their opportunity to take firm hold of the division.
The AFC South has been among the weaker divisions the past few seasons now, and Houston is the only 2-1 team, and there are two 0-3 teams (Jags and Tennessee Titans). With the 1-2 Indianapolis Colts having a tough test against the 3-0 Pittsburgh Steelers this Sunday, a win for the Texans would be a big step toward full control of the AFC South.
Jaguars vs. Texans Odds, Spreads, Total & Betting Lines
Unsurprisingly, Houston is among the biggest favorites of Week 4, and you can see that in the latest Jaguars vs. Texans odds at Caesars Sportsbook:
- Point Spread: Jacksonville Jaguars +7 (-110) vs. Houston Texans -7 (-110)
- Money Line: Jacksonville Jaguars (+250) vs. Houston Texans (-310)
- Game Total (Over/Under): Over 45.5 (-110) vs. Under 45.5 (-110)
Jaguars vs. Texans Predictions: Houston First Half -4 (-110 at Caesars Sportsbook)
A point spread right on the key number of seven has oddsmakers doing us no favors, and as for the total, it feels right on point with what we expected. Therefore, we decided to look elsewhere for the best bet from our Jaguars vs. Texans predictions, and we found a market that we love.
That would be Houston to take control of the game early on, just like we saw the Bills do to the Jags on Monday Night Football. That would be putting it lightly as well - Buffalo scored a touchdown on all five first-half possessions, taking a 34-3 lead into the half.
We certainly can’t expect that from the Texans this Sunday, but we do expect them to come out hot following such a rough showing last weekend against the Vikings. We noted the aspects that Jacksonville needs to focus on to stay positive, but they were reaches to say the least, and we simply haven't seen a motivated team come onto the field from Doug Pederson’s guys.
Look for Houston QB C.J. Stroud to exploit a terrible Jacksonville secondary and help the best bet from our Jaguars vs. Texans predictions of Houston -4 in the first half (-110 at Caesars Sportsbook) hit!
Jaguars vs. Texans Injury Report & Latest News
We’d love to see Houston RB Joe Mixon back on the field to help with our Jaguars vs. Texans predictions, and you can see the injury report for both teams following Thursday’s practices:
JAX Jaguars:
- RB Tank Bigsby - LP
- WR Gabe Davis - LP
- OL Cam Robinson - LP
- OL Anton Harrison - LP
- CB Jarrian Jones - LP
- CB Montaric Brown - LP
- S Darnell Savage Jr. - LP
- TE Evan Engram - DNP
- LB Foyesade Oluokun - DNP
- LB Devin Lloyd - DNP
HOU Texans:
- WR Nico Collins - LP
- DT Folorunso Fatukasi - LP
- RB Joe Mixon - DNP
- RB Dameon Pierce - DNP
- WR Tank Dell - DNP
- S Jimmie Ward - DNP
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Player News
Saints TE Foster Moreau said the QB1 role is “anyone’s job for the taking.”
It’s possible Moreau is just trying to speak positively of a quarterback room that could be in flux for much of the 2025 season, but the veteran tight end said neither Tyler Shough or Spencer Rattler did much to separate themselves from one another during offseason programs. Shough was selected at No. 40 overall by the Saints in this year’s draft, and will almost certainly get a chance to start at some point in the season, but Rattler could also get a look after throwing for 1,317-4-5 in seven games as a rookie. Rattler only completed 57 percent of his passes last season, and doesn’t have much promise as a fifth-round pick, but there may be room for him to see some action in what might be the worst QB room in the league this season. Regardless, this competition will one to watch throughout the offseason as first-year head coach Kellen Moore hopes to find a reliable option come Week 1.
Free agent RB Nyheim Hines said he is hoping to sign with a team before training camp.
Hines suffered a torn ACL during a jet-ski accident in 2023 and hasn’t played an NFL game since. The running back/return man said he believes his knee is now fully recovered and is hoping he can join a team before the start of training camp. Hines caught 30 passes for 241 yards and one touchdown in 2022 while splitting time with the Colts and Bills, and also returned 19 kicks for 554 yards and two scores. At 28 years old, there should be plenty of teams interested in giving him a look due to his special teams prowess and abilities in the passing game, but he’ll be far from a lock to make a roster wherever he lands.
Speaking on the Giants Huddle podcast, TE Theo Johnson said he is healthy after undergoing foot surgery last season.
Johnson caught 29 passes for 331 yards and one touchdown last season, but saw his rookie campaign come to an end due to a foot injury. Now healthy and ready to get back to work, the second-year tight end is hopeful he can continue where he left off before his injury, when he went for 26-293-1 over an eight-game stretch. It’s far from elite production, but Johnson posted an impressive 9.93 RAS during the 2024 NFL Scouting Combine and averaged a solid 12.2 YPR during his four years at Penn State. He won’t be on the fantasy radar to start the season, but Johnson could have some upside if he emerges as a primary receiving threat this season.
The Athletic’s Kevin Fishbain says Ben Johnson “seemed confident” that Luther Burden (soft tissue) would be ready at the start of training camp.
Burden has been sidelined for most of the offseason while dealing with an undisclosed injury. The rookie second-rounder also remains unsigned. While it’s been a slow start to Burden’s pro career, a return by training camp should give him plenty of time to get up to speed before the start of the season. Even when Burden acclimates himself to the offense, he’ll likely slot in as the team’s No. 3 receiver with Rome Odunze and D.J. Moore expected to serve as the primary options in two receiver sets. Burden makes for an intriguing late-round pick in deeper leagues, but is unlikely to enter the season with much fantasy upside.
ESPN’s Jeremy Fowler said Terry McLaurin is “not happy with where things are with an extension.”
Fowler adds that the Commanders have “a couple of weeks here to make progress” before training camp begins on July 22. McLaurin has skipped all offseason workouts thus far, so it stands to reason he could continue the absentee strategy later this month. Training camp is a critical time for NFL teams, allowing players to safely ramp up ahead of preseason play, not to mention the regular season. McLaurin profiles as a fantasy football WR2 this year.
The Athletic’s Mark Puleo reports, Chargers head coach Jim Harbaugh “has been added as a defendant in a class-action lawsuit filed by 11 anonymous students against former University of Michigan offensive coordinator Matt Weiss.”
Weiss “has been accused of hacking the email, social media and cloud storage accounts of thousands of female athletes and downloading intimate photos and videos.” Per Puleo, “the amended complaint... alleges that Harbaugh” and “university officials knew that Weiss had been accessing the plaintiffs’ private information when they allowed him to coach in the Fiesta Bowl on Dec. 31, 2022.” Harbaugh previously told reporters that “he didn’t learn of allegations involving Weiss until after the Fiesta Bowl,” saying he was “completely shocked” and “disturbed” upon hearing the allegations. Weiss has worked for both Jim and John Harbaugh, dating back to 2007; Stanford (2007-2008) and Michigan (2021-2022) with Jim, and the Ravens (2009-2020) with John. Jim coached at Michigan from 2015-2023. Per Puleo, “allegations of computer hacking against Weiss date to 2015, when he was with Baltimore.” Neither Michigan nor the Chargers responded to Puleo’s request for a comment.