Jaguars vs. Texans Predictions, Picks & Odds: NFL Week 4, Sunday 9/29

After a couple of years of things looking like the Jacksonville Jaguars were going to start taking over the AFC South for a while, the Houston Texans have swooped in and had something to say about that. Even still, these division rivalries never seem to disappoint, which is why we’re here to provide you with our best Jaguars vs. Texans predictions.
Also, even if you already have Jaguars vs. Texans picks in mind, you’ll still want to check out everything below, as we have a generous $1,000 Caesars Sportsbook sign up promo for you as well!
Jaguars vs. Texans Predictions For NFL Week 4, Sunday 9/29
After making QB Trevor Lawrence the highest-paid player in the NFL on an annual basis (at the time) this offseason, it’s safe to say that the Jags were fully bought in. With his college mate RB Travis Etienne by his side, optimism in Jacksonville couldn’t have been higher.
Well, an 0-3 start has turned the tide, while the Texans are finding ways to use their abundance of weapons. However, don’t get it twisted - it hasn’t been perfect in Houston either. They’re coming off a 34-7 beatdown by the hands of the Minnesota Vikings, so this division rivalry is something both teams need in a big way.
Jacksonville Jaguars: Trying To Find Positives
It may be difficult to find things for the Jags to hang their hat on after their most recent loss, which was broadcast for the entire world to see on Monday Night Football. The 47-10 thrashing was as bad as it gets, but they can at least say that the Buffalo Bills may be the best team in the entire NFL.
As for their other losses, the first was against another AFC East team - the Miami Dolphins - which was a game that they controlled for quite a bit. The other was against the Cleveland Browns, which was one where they at least held them to just 18 points. Again, things aren’t easy in northern Florida, but these are things that the Jags need to focus on.
Houston Texans: Taking Control Of The AFC South
With the Texans snagging RB Joe Mixon and WR Stefon Diggs this offseason, expectations were that they would build on last year’s impressive 10-7 campaign. While it hasn’t been perfect, this matchup with the Jags is their opportunity to take firm hold of the division.
The AFC South has been among the weaker divisions the past few seasons now, and Houston is the only 2-1 team, and there are two 0-3 teams (Jags and Tennessee Titans). With the 1-2 Indianapolis Colts having a tough test against the 3-0 Pittsburgh Steelers this Sunday, a win for the Texans would be a big step toward full control of the AFC South.
Jaguars vs. Texans Odds, Spreads, Total & Betting Lines
Unsurprisingly, Houston is among the biggest favorites of Week 4, and you can see that in the latest Jaguars vs. Texans odds at Caesars Sportsbook:
- Point Spread: Jacksonville Jaguars +7 (-110) vs. Houston Texans -7 (-110)
- Money Line: Jacksonville Jaguars (+250) vs. Houston Texans (-310)
- Game Total (Over/Under): Over 45.5 (-110) vs. Under 45.5 (-110)
Jaguars vs. Texans Predictions: Houston First Half -4 (-110 at Caesars Sportsbook)
A point spread right on the key number of seven has oddsmakers doing us no favors, and as for the total, it feels right on point with what we expected. Therefore, we decided to look elsewhere for the best bet from our Jaguars vs. Texans predictions, and we found a market that we love.
That would be Houston to take control of the game early on, just like we saw the Bills do to the Jags on Monday Night Football. That would be putting it lightly as well - Buffalo scored a touchdown on all five first-half possessions, taking a 34-3 lead into the half.
We certainly can’t expect that from the Texans this Sunday, but we do expect them to come out hot following such a rough showing last weekend against the Vikings. We noted the aspects that Jacksonville needs to focus on to stay positive, but they were reaches to say the least, and we simply haven't seen a motivated team come onto the field from Doug Pederson’s guys.
Look for Houston QB C.J. Stroud to exploit a terrible Jacksonville secondary and help the best bet from our Jaguars vs. Texans predictions of Houston -4 in the first half (-110 at Caesars Sportsbook) hit!
Jaguars vs. Texans Injury Report & Latest News
We’d love to see Houston RB Joe Mixon back on the field to help with our Jaguars vs. Texans predictions, and you can see the injury report for both teams following Thursday’s practices:
JAX Jaguars:
- RB Tank Bigsby - LP
- WR Gabe Davis - LP
- OL Cam Robinson - LP
- OL Anton Harrison - LP
- CB Jarrian Jones - LP
- CB Montaric Brown - LP
- S Darnell Savage Jr. - LP
- TE Evan Engram - DNP
- LB Foyesade Oluokun - DNP
- LB Devin Lloyd - DNP
HOU Texans:
- WR Nico Collins - LP
- DT Folorunso Fatukasi - LP
- RB Joe Mixon - DNP
- RB Dameon Pierce - DNP
- WR Tank Dell - DNP
- S Jimmie Ward - DNP
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Player News
NBC Sports Bay Area’s Matt Maiocco said “it’s not out of the question” for Brandon Aiyuk (knee) to play in Week 1, but believes landing on the physically unable to perform list is still likely.
Maiocco said Aiyuk is “doing really well” in his ACL and MCL injury recovery, saying the knee is even ahead of schedule.” However, the 49ers “want to be extra cautious with him” and “the feeling inside the organization has always been don’t take any chances.” Maiocco expects Aiyuk to be placed on the PUP list when veterans report to training camp on July 22nd and to remain on the PUP list when the regular season begins. Returning in Week 5 or Week 6 is “quite possible” and Maiocco believes Aiyuk will be “getting up to speed quickly.”
Najee Harris’ agent Doug Hendrickson said that Harris “sustained a superficial eye injury” during “a fireworks mishap” on the 4th of July, “but is fully expected to be ready for the upcoming NFL season.”
There is more to learn about Harris’ injury specifics and his road to recovery, but this is good news. A surface-level injury suffered by the eye is, of course, different than an elbow abrasion. But from a vision standpoint, Harris is seemingly expected to be in football shape come September after suffering an eye injury that resulted in two hospital visits just last weekend. We will wait for more details to fully assess his 2025 outlook, though it stands to reason that the coaching staff will safely ease him into live action.
The Mercury News reports Najee Harris was injured by a “fireworks explosion” during a July 4th celebration.
The incident reportedly occurred at 12:20 a.m. on July 5th. Per the report, “the nature and severity of Harris’ injury could not immediately be verified” and “officials said that other people had been hurt in the blast, but did not specify their number or how severely any of them had been injured.” Harris reportedly visited two hospitals following the accident. Neither the mode of transport nor the reason for the relocation was shared. Rumors swirled online and locally earlier today about the nature of the injury, but details have been difficult to come by and “Antioch police said on Thursday they were still investigating the incident actively.”
ESPN reports that Demarcus Robinson “pleaded no contest this week to a misdemeanor DUI charge and was sentenced to three years’ probation.”
Robinson “was ordered to pay a $390 fine and to complete court-mandated programs, including a three-month alcohol education program.” He was arrested in November 2024 after being observed by police officers driving more than 100 MPH. The arrest occurred while Robinson was a member of the Rams. Robinson could still be suspended by the league, but a ruling has not yet been given. The 49ers reportedly knew that a suspension was possible when they signed him this offseason.
ESPN’s Don Van Natta and Kalyn Kahler report that NFLPA head Lloyd Howell Jr. “is working as a paid, part-time consultant for The Carlyle Group,” a private equity firm with league approval to invest in NFL franchises.
Last August, the NFL approved just “three private equity firms and a consortium of firms” as potential NFL-team investors, for minority stakes that are not to exceed 10.0 percent. The Carlyle Group is one such firm, where Howell works as an “operations executive in The Carlyle Group’s aerospace and defense investment team.” He earned $3.4 million in the role last year. Although Howell’s department does not directly overlap with a potential NFL investment, a union lawyer asked him “to consider resigning from the private equity firm to avoid the appearance of a conflict of interest.” Howell also notably serves on three boards of directors, including GE HealthCare, Moody’s and ManTech, earning six-figure compensation with at least two of them. Per the report, “longtime union observers and executives said they find it baffling that Howell would continue to work at The Carlyle Group while leading the union,” and Jim Quinn, the NFLPA’s former lead outside counsel, notes that neither of Howell’s predecessors were allowed to be paid for outside work. The NFLPA recently “struck a confidentiality agreement with the NFL to keep the details of a January arbitration ruling under wraps from players,” following an investigation into potential top-down collusion regarding player salary guarantees. Last month, the union reportedly hired a law firm “to work with a special committee of players to review Howell’s activities as the executive director,” after ESPN broke, in May, that “the FBI and federal prosecutors are investigating the union’s financial dealings related to a multibillion-dollar group-licensing firm,” which Howell holds a board seat on.
Falcons reporter Tori McElhaney believes UDFA WR Nick Nash has long odds of making the 53-player roster, but notes “there absolutely could be a practice squad spot for him.”
Undrafted free agents always have an uphill climb toward a spot on the 53-player roster. Nash intrigued the dynasty community by leading 2024 FBS wide receivers in targets (171), receptions (104), yards (1,382) and receiving touchdowns (16). McElhaney projects Drake London, Darnell Mooney, Ray-Ray McCloud and KhaDarel Hodge are locked in as the Falcons’ top four wide receivers. WR/KR Jamal Agnew “could be the Falcons’ return man.” WRs Chris Blair and Casey Washington could also be ahead of Nash, though McElhaney did compliment Nash’s high-pointing ability through spring practices. The former San Jose State Spartan will likely find his way onto a practice squad this year, be it with the Falcons or elsewhere. He is not relevant in re-draft formats at this time.