NFL Week 10 Picks Straight Up, Odds For All 14 Games & Spread Picks

Through 9 weeks, two things appear clear: the Kansas City Chiefs are the team to beat in the AFC, and the Detroit Lions are the team to beat in the NFC. Five years ago, nobody would have believed that second portion, but here they are!
That being said, we also just witnessed the 2024 NFL trade deadline, seeing significant movement involving key players at key positions. Will any of these moves prove to be what the teams needed and pay off?
Only time will tell, but at least we’ll get to watch it all unfold right before our eyes! As always, we’re here to bring you our expert NFL Week 10 picks, featuring SU picks and picks ATS. Let’s get into it!
NFL Week 10 Picks Straight Up For All 14 Games At BetMGM Sportsbook
This week features a total of 14 thrilling games on the agenda, so jump into each matchup alongside my NFL Week 10 picks. In the following section, you will find my predictions, with the teams I anticipate will emerge victorious highlighted in bold:
- Cincinnati Bengals vs. Baltimore Ravens (TNF)
- New York Giants vs. Carolina Panthers (Germany)
- New England Patriots vs. Chicago Bears
- San Francisco 49ers vs. Tampa Bay Buccaneers
- Denver Broncos vs. Kansas City Chiefs
- Buffalo Bills vs. Indianapolis Colts
- Pittsburgh Steelers vs. Washington Commanders
- Minnesota Vikings vs. Jacksonville Jaguars
- Atlanta Falcons vs. New Orleans Saints
- Tennessee Titans vs. Los Angeles Chargers
- New York Jets vs. Arizona Cardinals
- Philadelphia Eagles vs. Dallas Cowboys
- Detroit Lions vs. Houston Texans (SNF)
- Miami Dolphins vs. Los Angeles Rams (MNF)
You are welcome to accompany me in placing all of my NFL Week 10 picks at BetMGM Sportsbook!
NFL Week 10 Early Spread Picks & Predictions
Giants vs. Panthers Spread Pick: Sunday, November 10th
Believe it or not, let’s roll with the Panthers to cover the 6.5-point spread in their Week 10 game against the Giants, particularly since both teams are having trouble on offense. Carolina ranks 31st in points per game (16.3) and has been inconsistent, but their recent performances show some improvement.
The offensive line is doing better at creating running lanes, averaging 4.4 yards per carry, which is slightly better than New York’s 4.3-yard average. This advantage could allow Carolina to control the game pace and limit the Giants’ offensive chances. On defense, the Panthers need to focus on stopping a Giants offense that is last in points per game (15.4) and 26th in total yards.
New York has had difficulty maintaining drives, as shown by their 23rd rank in passing yards per attempt (6.0) and overall inefficiency. If Carolina’s pass rush can put pressure on the Giants’ weak offensive line, they can keep New York’s scoring down.
The combination of the Giants' inconsistent offense and Carolina’s ability to control possession gives the Panthers a good chance to stay competitive and cover the spread as a 6.5-point underdog in Munich.
Falcons vs. Saints Spread Pick: Sunday, November 10th
How about a road favorite, eh? The Falcons should be able to cover the 3.5-point spread in Week 10 against the Saints despite being on the road.
They have been gaining momentum on offense and have a strong defense, evidenced by scoring an average of 24.6 points per game, ranking 12th, and they are 8th in total yards with 364.8. Their passing game is effective, averaging 7.9 yards per attempt, which is 7th in the league.
This puts them in a good position to take advantage of the Saints' weak secondary, which gives up 239.9 passing yards per game and ranks 24th in yards allowed per pass attempt at 7.1. On defense, Atlanta has improved its run stopping, allowing only 4.6 yards per carry, while the Saints allow 5.1 yards per carry.
If the Falcons can limit the Saints' running game, it will force New Orleans into passing situations where they have not been very consistent. Overall, Atlanta's strong offense and the Saints' defensive issues suggest that the Falcons can control the game and cover the spread.
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NFL Week 10 Odds For All 14 Games Provided By BetMGM Sportsbook, November 2024
We just unveiled our NFL Week 10 picks, and below are the spread odds for each matchup, provided by BetMGM Sportsbook:
- Bengals +6.5 (-120) vs. Ravens -6.5 (-110)
- Giants -6 (-110) vs. Panthers +6 (-110)
- Patriots +6 (-115) vs. Bears -6 (-105)
- 49ers -5.5 (-110) vs. Buccaneers +5.5 (-110)
- Broncos +8.5 (-110) vs. Chiefs -8.5 (-110)
- Bills -4 (-110) vs. Colts +4 (-110)
- Steelers +3 (-115) vs. Commanders -3 (-105)
- Vikings -4.5 (-110) vs. Jaguars +4.5 (-110)
- Falcons -3.5 (-110) vs. Saints +3.5 (-110)
- Titans +7.5 (-110) vs. Chargers -7.5 (-110)
- Jets +1 (-120) vs. Cardinals -1 (+100)
- Eagles -7.5 (-105) vs. Cowboys +7.5 (-115)
- Lions -3.5 (-110) vs. Texans +3.5 (-110)
- Dolphins +1 (-110) vs. Rams -1 (-110)
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Player News
Dolphins signed No. 13 overall pick DT Kenneth Grant to a four-year contract.
ESPN’s Jeremy Fowler reports that Grant will sign his contract today. The former Michigan defensive tackle is expected to fill a major void left by Christian Wilkins, who left for the Raiders in the 2024 offseason. Grant totaled 32 tackles, three sacks, and seven TFLs in his final season at Michigan and excelled at stopping the run while also generating 27 pressures in his final season, per PFF.
Beat reporter John Hendrix reports that free agent WR Donovan Peoples-Jones is among the 16 players that the Saints will host for their rookie minicamp.
Peoples-Jones last played regular season snaps with the Lions back in 2023, when he caught 13-of-24 targets for 155 yards. He is highly unlikely to return to fantasy relevance at this point but could perhaps sign on as a special teams contributor.
Titans signed fourth-round pick WR Elic Ayomanor to a four-year contract.
Ayomanor will now begin learning behind Calvin Ridley. Although Ayomanor is unlikely to find a meaningful role in year one, dynasty managers should note his status as training camp gets underway this summer. The former Stanford receiver flashed big-play ability in his two college seasons.
Buccaneers signed seventh-round pick WR Tez Johnson to a four-year contract.
Johnson will serve as a rotational deep-threat option for Baker Mayfield. His thin frame (5'10/154) simply does not lend itself to the repeated hits one incurs in a full-time role. Johnson did earn 100-plus targets in his two seasons at Oregon, though. His big-play style make him a better fit in best ball for now, pending any major on-field breakthroughs.
Giants waived DT Casey Rogers.
Rogers was a 2024 undrafted free agent and logged 33 defensive snaps for the Giants in his rookie season. He is credited with zero tackles and/or sacks. He may find his way onto another roster as a practice squad option.
Vikings signed third-round pick WR Tai Felton to a four-year contract.
Felton is quietly in play to challenge Vikings No. 3 WR Jalen Nailor in training camp. Nailor (5'11/190) caught 28-of-42 targets for 414 yards and six touchdowns in his first season as a starter last year, with the latter category buoying his fantasy productivity. Felton (6'1/183), meanwhile, caught 96-of-143 targets for 1,119 yards and nine touchdowns while averaging 2.32 yards per route run in his final college season. Fantasy managers should monitor Felton’s training camp reports this summer, as he could have a matchup-based WR5 role if everything falls into place.