Colts vs. Titans Predictions, Picks & Odds: NFL Week 6, Sunday 10/13

It seems as though we have at least one classic AFC South rivalry on a weekly basis, and we have one this Sunday with the Tennessee Titans hosting the Indianapolis Colts. They both still have work to do to get to a .500 record let alone catch the Houston Texans, but still, we’ve got our best Colts vs. Titans predictions for the matchup.
After we go through the Colts vs. Titans odds and the best bet from our Colts vs. Titans picks, we’ll also have a monster $1,500 BetMGM Sportsbook bonus for you, so be sure to check out everything below!
Colts vs. Titans Predictions For NFL Week 6, Sunday 10/13
It’s back-to-back AFC South rivalry games for the Colts with this one coming on the heels of allowing the Jacksonville Jaguars to earn their first win of the season. Speaking of which, the Titans only just notched theirs on Monday Night Football in Week 4.
We say “just” as they are coming off a Week 5 bye, so they’re still sitting at 1-3 on the year. In other words, this is far from a matchup of titans, no pun intended. Both teams have questions at QB as well, so it’s no surprise that we see this game at nearly a pick ‘em, which it is as some sportsbooks.
Regardless, we’ve still found an approach to the matchup that we love for the best bet from our Colts vs. Titans predictions.
Indianapolis Colts: Battling Through Injuries
We mentioned QB question marks, and that would be second-year signal-caller Anthony Richardson for the Colts. However, just as he did for the Cleveland Browns last year, 39-year-old Joe Flacco came in to lead Indy to a win over the Pittsburgh Steelers two weeks ago.
There’s a chance we see Richardson back under center this Sunday, but he isn’t the only injury concern for the Colts. Star RB Jonathan Taylor also missed Indy’s most recent game, and at this point, injuries always have to be considered for the Wisconsin product.
Tennessee Titans: Will Will Play?
The question above is, of course, referencing Titans QB Will Levis. He too was drafted just two seasons ago alongside Richardson, and the question is fair regarding both his recent injury and play.
Levis has made some wildly questionable decisions through the first few games, including each of the first two weeks where many fans would argue that he cost them the game completely. Fans were already calling for his benching after Week 3, which ultimately culminated in his shoulder injury on Monday Night Football in Week 4.
With Tennessee having since had a week off, it will be interesting to see how the team handles his return.
Colts vs. Titans Odds, Spreads, Total & Betting Lines
When we shared that this game was set to be a tight one, that was no exaggeration. Here are the latest Colts vs. Titans odds at BetMGM Sportsbook:
- Point Spread: Indianapolis Colts -1 (-110) vs. Tennessee Titans +1 (-110)
- Money Line: Indianapolis Colts (-120) vs. Tennessee Titans (+100)
- Game Total (Over/Under): Over 42.5 (-110) vs. Under 42.5 (-110)
Colts vs. Titans Predictions: Over 42.5 Points (-110 at BetMGM Sportsbook)
We’re getting some solid value with the best bet from our Colts vs. Titans picks thanks to BetMGM, as this total is still being listed as high as 43.5 points elsewhere. Even still, we see this number being overly adjusted with the injury concerns.
Clearly, oddsmakers don’t have faith in two offenses that are dealing with the injuries we’ve already mentioned. However, Indy also has key position roles missing on defense, so it’s no surprise that we’ve seen them struggle, especially as of late.
The Colts just allowed 37 points to a then 0-4 Jags team, and even though they got the win the week prior, they allowed an anemic Steelers offense to put up 24 points. In fact, given that they won that game, it also proves that they can do their fair share of scoring as well.
Even in last week’s loss, Indy put up 34 points themselves! Admittedly, we know that Tennessee’s offense leaves a bit to be desired, but they can at least thrive against poor defenses like the Colts - they scored 31 points in their most recent matchup against the Miami Dolphins.
These teams still may not play the cleanest football, but mistakes can also lead to points, so the best bet from our Colts vs. Titans predictions is over 42.5 points (-110 at BetMGM Sportsbook).
Colts vs. Titans Injury Report & Latest News
Much of the breakdown for our Colts vs. Titans predictions involved injuries, so of course, we have the latest practice report for you (following Thursday’s):
IND Colts:
- WR Josh Downs - DNP
- CB Kenny Moore - DNP
- WR Michael Pittman - DNP
- RB Jonathan Taylor - DNP
- DE Kwity Paye - LP
TEN Titans:
- S Jamal Adams - DNP
- DT Keondre Coburn - DNP
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Player News
Titans waived OT Nicholas Petit-Frere.
The team signed C Sam Mustipher and OT Oli Udoh in corresponding moves. Petit-Frere failed to meet expectations after the Titans spent a third-round pick on him in 2022, allowing 35-plus quarterback pressures in 2-of-3 NFL seasons.
Cowboys signed OL Hakeem Adeniji, formerly of the Browns, to a contract.
The former 2020 sixth-round pick last took regular season snaps in 2022. Adeniji spent the 2023 season serving as a part-time special teams player, and although he was technically on the Browns’ 2024 roster, he missed the full season on injured reserve. Adeniji will likely handle a deep-backup/special teams role in Dallas this year.
Free agent QB Aaron Rodgers said on The Pat McAfee Show that he is currently focusing on matters in his personal life while mulling his future in the NFL.
In a wide-ranging discussion with McAfee, Rodgers said that he is still contemplating whether to play in 2025 or retire this offseason, though he has settled on a $10 million asking price, should he choose to stick around. Rodgers repeatedly, yet ambiguously, emphasized that caring for troubled members of his “inner circle” has been his offseason priority. Rodgers spoke positively of his recent visit with the Steelers, praising head coach Mike Tomlin, OC Arthur Smith, GM Omar Khan, QB coach Tom Arth and WR DK Metcalf, whom he called “a specimen” and a “great dude.” Rodgers downplayed reports about pitching Vikings head coach Kevin O’Connell on a union, saying much ado has been made about two old “friends” remaining in regular contact. The free agent QB also notably complimented Giants head coach Brian Daboll’s “beautiful football mind” but kept Giants-talk relatively succinct. Rodgers made clear that the rapidly approaching 2025 NFL Draft will have no bearing on his decision-making timeline, and he understands if the Steelers determine that they must move on without him. In short, it appears as though Rodgers will either sign with the Steelers or move on from football. The enigmatic quarterback gave few indications as to which direction he is leaning.
FOX NFL’s Jordan Schultz reports “interested teams believe Philadelphia would be open to future picks” for TE Dallas Goedert.
Goedert has become a popular trade candidate in the rumor mill. He is on the final year of his current contract and is undoubtedly looking for a new deal. The Eagles, on the other hand, haven’t made much noise about extending him and have generally tried to get out ahead of new contracts in recent years. The timing of this report suggests the Eagles are still trying to field offers for Goedert and the price may be dropping.
Browns GM Andrew Berry said Alabama QB Jalen Milroe has “rare physical talent.”
Berry continued with his praise of Milroe’s physical traits, saying he is maybe the only quarterback faster than Lamar Jackson. Milroe ran for 729 yards and a jaw-dropping 20 touchdowns in his final season at Alabama. Though the Browns don’t appear to be taking a quarterback with the No. 2 overall pick, they are up again at No. 33 and could even package that selection with another pick to get back into the first round. The Browns have held visits with all of the major quarterback prospects, including Milroe. They currently have Joe Flacco and Kenny Pickett on the roster, neither of whom is a long-term option.
Browns GM Andrew Berry said Colorado CB/WR Travis Hunter’s skill set is best suited for wide receiver.
Berry still didn’t rule out Hunter playing both positions at the next level. He also noted that he doesn’t think Hunter needs to be a two-way player to be worth the No. 2 overall pick that Cleveland holds. Hunter is currently the favorite to be taken with the second pick ahead of Penn State EDGE Abdul Carter and Colorado QB Shedeur Sanders. Giants GM Joe Schoen talked about Hunter yesterday as well. He noted the risks of playing Hunter on both sides of the ball but sounded more than willing to give it a shot. Between Schoen, Berry, and other reports, all signs point to Hunter at least getting some run on both sides of the ball, though not as much as he did in college. The receiver-needy Browns would likely deploy him as a wide receiver first, much to the pleasure of the fantasy football community.