NFL TNF Best Player Prop Picks: Rams vs. 49ers - Thursday, 12/12

We’ve got an all-California Thursday Night Football game to kick off Week 15 with the Los Angeles Rams heading a bit north to take on the NFC West rival San Francisco 49ers. With two teams that have been difficult to trust this season, we’re here to provide our best NFL TNF player prop picks as an alternate approach.
Better yet, we’ll also share a massive $1,500 BetMGM Sportsbook welcome offer to go along with our best Rams vs. 49ers player props to ensure it’s a great TNF matchup!
Best NFL Thursday Night Football Player Prop Picks
Divisional rivalries generally tend to create some closer-than-expected matchups, and with this one already having a spread of just a couple points, NFL TNF player prop picks will certainly be a preferred approach by many. Admittedly, these aren’t the easiest teams to get a read on.
However, we’ve done the digging for you and found two sports that we love. We have LA sitting at 7-6 and San Francisco sitting at 6-7, so they’ve had some up-and-down seasons, but there are still trends to be found. The first of which may surprise and the second of our Rams vs. 49ers player props has some great plus-money odds, so let’s get into our best bets.
Rams vs. 49ers Player Props: George Kittle Under 55.5 Receiving Yards (-110 at BetMGM Sportsbook)
That’s right - we’re starting our NFL TNF player prop picks with an under for a superstar at the TE position. There’s no doubt that 49er George Kittle is as good as it gets, and he just had another standout performance this past Sunday, but that was against a struggling Chicago Bears team.
In fact, we actually like that it has his line higher than we projected it to be given that recent performance. While it was certainly great, when facing better competition like the Buffalo Bills the week prior, Kittle had just one catch for seven yards.
Now, we aren’t expecting that either or saying that the Rams are on par with the Bills, but they did just beat them. In fact, LA held Bills TE Dawson Knox to just five yards on one catch. Along with all that, Kittle has surprisingly struggled against his division rival.
He was injured when these teams met earlier this season, but his woes date back much further. In his past four meetings with the Rams, Kittle has been held to 10, 24, 39 and 30 receiving yards. Even the game prior was a 50-yard performance, and we have to go back to 2020 since he last exceeded that against LA.
It’s not what we would normally expect from him, but for this matchup specifically, we’re starting our NFL TNF player prop picks with George Kittle under 55.5 receiving yards (-110 at BetMGM Sportsbook).
Rams vs. 49ers Player Prop Bets: Kyren Williams 1st Half Anytime TD Scorer (+175 at BetMGM Sportsbook)
We also promised some plus-money odds included with our Rams vs. 49ers player props, and that’s on the LA side of the matchup. Taking RB Kyren Williams to score a touchdown is about the most chalk pick imaginable, which is also why the odds present little to no value.
However, if we isolate him to find the endzone in the first half, we’re getting far better odds, and we aren’t scared about the time constraint. The 49ers defense has been a shell of what it was expected to be for many reasons, including that superstar LB Fred Warner has been banged up all season.
San Francisco’s run defense specifically has been vastly underperforming, and that’s putting it mildly. They’ve given up 19 rushing touchdowns this season, which is tied with the Carolina Panthers for the second-most in the NFL. That’s not the type of company they want to keep, and LA has already been a reason for those struggles.
When these teams met in Week 3, Williams scored two touchdowns, which was in the middle of six straight games with at least one touchdown to begin this year. In his first-ever game against San Francisco last year, he also had a touchdown (scored in the second quarter).
With how much the 49ers run defense has declined, we’re adding to our NFL TNF player prop picks with the unique approach of Kyren Williams to score a first half touchdown (+175 at BetMGM Sportsbook).
Thursday Night Football Player Props At BetMGM Sportsbook
Now that you’ve seen the analysis for our best NFL TNF player prop picks, here are some other Rams vs. 49ers player props at BetMGM Sportsbook to consider:
Passing Yards:
- Matthew Stafford: Over 241.5 (-115) vs. Under 241.5 (-115)
- Brock Purdy: Over 244.5 (-115) vs. Under 244.5 (-115)
Rushing Yards:
- Kyren Williams: Over 71.5 (-115) vs. Under 71.5 (-115)
Receiving Yards:
- Cooper Kupp: Over 63.5 (-110) vs. Under 63.5 (-120)
- Puka Nacua: Over 87.5 (-115) vs. Under 87.5 (-115)
- George Kittle: Over 55.5 (-120) vs. Under 55.5 (-110)
Anytime TD Scorer:
- Kyren Williams: -175
- Isaac Guerendo: -150
- Patrick Taylor: -115
- Puka Nacua: +110
- Cooper Kupp: +140
- George Kittle: +155
- Deebo Samuel: +160
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Player News
Panthers released TE Jordan Matthews.
Matthews converted to tight end a few years ago and hasn’t made much noise at the position. The change has, however, likely kept him in the league for a few more seasons. He appeared in four games with the Panthers last year but didn’t record any stats on offense. The Panthers also released or waived WR Dax Milne, C Andrew Raym, and TE Colin Granger.
Dolphins released LS Blake Ferguson.
The team also waived CB Ryan Cooper Jr., DT Neil Farrell and OL Chasen Hines. Ferguson has been the team’s long snapper for five seasons and earned a three-year contract extension just before the 2023 season. He should be able to find work snapping footballs farther than the average snap elsewhere in the league.
DetroitLions.com’s Tim Twentyman believes rookie WR Isaac TeSlaa “could make his earliest impact on special teams.”
It’s not much of a surprise, as most rookies cut their teeth with special teams duties. Twentyman mentioned return duties as a possibility, though the former Razorback never returned kicks or punts in college. At 6'4/212 with 4.43 wheels, TeSlaa is an explosive athlete who never translated his physical traits to on-field production at Arkansas. The Lions clearly saw potential for him to do so in the pros and traded two future third-round picks to move up to No. 70 overall for him. It’s going to be a slow burn for TeSlaa in the pros, making him a dynasty-only fantasy option.
Vikings head coach Kevin O’Connell said the team does not “have any feelings on competition” when asked about the quarterback room.
O’Connell was asked about a potential quarterback competition on the Rich Eisen Show Wednesday and was unclear on whether J.J. McCarthy would have to compete to start. He said, “we’ve got an obligation as coaches to put our players in position to attack that competition phase.” O’Connell discussed first putting Brett Rypien and the newly acquired Sam Howell in a position to play before any competition would occur. He continued that McCarthy is “owning it” this offseason and is taking snaps from starting center Ryan Kelly. After missing last season with a torn meniscus, McCarthy has been ramping up workouts in the offseason and is the front-runner to start for the Vikings in 2025. As of now, Howell looks to be reinforcement at the backup spot in case it turns out McCarthy is not ready to start.
Texans re-signed DT Foley Fatukasi.
Fatukasi initially joined the Texans last offseason on a one-year contract. The 30-year-old was a rotational defensive lineman, tallying four tackles for loss and one sack. He returns to Houston for 2025, where he will be a part of a deep Texans front seven.
NFL Network’s Tom Pelissero reports Tyreek Hill’s second wrist surgery was part of the original plan and his timeline remains unchanged.
Hill announced the second surgery on social media and Pelissero quickly added some context to the situation. The speedy receiver suffered the wrist injury just before the start of the season and it lingered throughout the year, though he never missed a game because of it. If the second surgery truly is a non-story, an offseason to recover might be what Hill needs to return to form after a down 2024 season. On the other hand, Hill is 31 years old, played his worst football last year, and his offense prioritized targets for Jonnu Smith and De’Von Achane. As it stands, Hill might have the highest risk-reward split in fantasy drafts.