49ers vs. Seahawks Predictions, Picks & Odds: Thursday Night Football, 10/10
Don’t look now, but the NFC West is completely up for grabs, which is something not many fans anticipated heading into the season. That is primarily thanks to the San Francisco 49ers performing below expectations and the Seattle Seahawks exceeding them, and they’ll be facing off on Thursday Night Football to kick off Week 6.
That’s why we’re here to share our best 49ers vs. Seahawks predictions, which will come alongside a brand new FanDuel Sportsbook sign up bonus for a chance at a 60x boost!
49ers vs. Seahawks Predictions For Thursday Night Football, NFL Week 6
The Seahawks had a fantastic opportunity to become one of just two teams in the NFC to advance to 4-1 this past Sunday, but they fell just short with their potential game-winning field goal blocked. While they were within reach, it’s also worth noting that it was a home game against the New York Giants.
Similarly, the 49ers collapsed against another division rival - the Arizona Cardinals - to fall below .500 on the season. Perhaps more importantly given how the division looks right now, that brought them to 0-2 against NFC West opponents.
Those two losses were both blown leads, and that is something that we have fresh on our minds when it comes to the market that we decided upon for the best bet from our 49ers vs. Seahawks picks.
San Francisco 49ers: Inability To Finish The Job
Most of the discussions surrounding the 49ers this season have been regarding injuries, and rightfully so. Of course, it all started with superstar RB Christian McCaffrey, but outside of him, the team has largely gotten back on track.
Both TE George Kittle and WR Deebo Samuel have returned to the field, and even backup RB Jordan Mason has looked fantastic, as fantasy football managers will tell you. However, they are having trouble closing out games. They blew two double-digit leads to the Los Angeles Rams two weekends ago and a 23-10 lead just two days ago.
Seattle Seahawks: Not Ceasing The Moment
For the 49ers late-game faults, there have been just as many struggles for the Seahawks recently. This came after their 3-0 start, and with the 49ers sitting at 1-2 at that point, they had all the opportunity to take full control of the NFC West.
That was especially true this past Sunday, as the Giants had to travel cross-country to face Seattle, which is a team that is considered among the bottom tier of the NFL. These past two losses are beginning to prove what many fans said after their 3-0 start - it was fool’s gold thanks to playing the Denver Broncos, New England Patriots and Miami Dolphins.
49ers vs. Seahawks Odds, Spreads, Total & Betting Lines
We absolutely love the spot we found regarding the 49ers vs. Seahawks odds, and you can see the latest lines at FanDuel Sportsbook for the standard markets below:
- Point Spread: San Francisco 49ers -3 (-115) vs. Seattle Seahawks +3 (-105)
- Money Line: San Francisco 49ers (-164) vs. Seattle Seahawks (-138)
- Game Total (Over/Under): Over 47.5 (-110) vs. Under 47.5 (-110)
49ers vs. Seahawks Predictions: San Francisco First Half -1.5 (-105 at FanDuel Sportsbook)
We’re only slightly varying the best bet from our 49ers vs. Seahawks predictions from the standard markets above. Given what we already mentioned about San Francisco’s blown leads, it should come as no surprise that we’re isolating the first half.
The 49ers have had no issues getting out to leads this season, including against the other NFC West teams not involved in this matchup. The aforementioned 23-10 lead over the Cards was their halftime lead, and they were also up by seven against the Rams at the break.
Even in the game sandwiched between those two, the 49ers had a 20-3 halftime lead, albeit against the Patriots. Regardless, they have been great on both sides of the ball in the first half of games. Their eight points allowed per game in the first half are the fourth-fewest in the NFL, while their 16 first half points scored per game are also the fourth-most.
If you want to stick with the standard markets for your 49ers vs. Seahawks picks, it’s worth noting that San Francisco is 4-1 against the spread in their last five meetings with Seattle. However, we’re sticking with San Francisco -1.5 in the first half (-105 at FanDuel Sportsbook) as the best bet from our 49ers vs. Seahawks predictions.
49ers vs. Seahawks Injury Report & Latest News
Now that you have our 49ers vs. Seahawks predictions and the latest 49ers vs. Seahawks odds, here is the latest injury news following Monday:
SF 49ers:
- WR Chris Conley - DNP
- DT Jordan Elliot - DNP
- LB D. Flannigan-Fowles - DNP
- S Talanoa Hufanga - DNP
- K Jake Moody - DNP
- CB Charvarius Ward - DNP
- S JiAyir Brown - LP
- TE George Kittle - LP
- LB Fred Warner - LP
SEA Seahawks:
- LB Derick Hall - DNP
- DT Byron Murphy II - DNP
- LB Uchenna Nwosu - DNP
- CB Riq Woolen - DNP
- TE Pharaoh Brown - LP
- LB Boye Mafe - LP
- S Julian Love - LP
- S Rayshawn Jenkins - LP
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Player News
Packers signed WR Bo Melton, RB Emanuel Wilson, and P Daniel Whelan to their exclusive rights free agent tenders.
Melton caught on with the Packers in 2023, totaling 16 receptions for 218 yards and a touchdown in five games. He added eight receptions for 91 yards in 17 games last season. Melton will continue to be a depth piece in an already-deep Packers wide receiver room. Wilson has also been with the Packers for two seasons and rushed for 502 yards and four touchdowns as Josh Jacobs’ immediate backup last season. He will compete with MarShawn Lloyd for that role again. Whelan is the team’s punter and will be back for 2025. All three signed their exclusive rights free agent tender and will essentially be on one-year contracts this season.
Seahawks re-signed Johnathan Hankins to a one-year contract.
Hankins hasn’t had a PFF run defense grade above 52.4 since 2020 and is primarily called on to play early downs. He turned 33 in March. He’ll be a complimentary piece behind Jarran Reed and Byron Murphy II if he makes the roster out of training camp.
Chargers placed the UFA tender on RB J.K. Dobbins.
This gives the Chargers exclusive negotiating rights if he does not sign with a team by July 22 or the first 2025 NFL training camp opens, whichever comes first. The tag is mainly useful for compensatory pick reasons as Dobbins will still count towards Los Angeles’ haul in the formula if signed before then. The Chargers currently do not project to add a pick in 2026 per Over The Cap’s Nick Korte.
49ers signed OT D.J. Humphries.
Humphries played in only two games for the Chiefs last year as he spent most of the season rehabbing a late 2023 torn ACL on his own. He wasn’t appreciably good in either of those games, but he was rusty and does have a history of better than that. Entering his age-32 season for the 49ers, he’ll probably be trying to win the right tackle job opposite Trent Williams in training camp.
Patriots released LS Joe Cardona.
The team selected his replacement, Julian Ashby, in the seventh round of the draft. This snapper of balls who are longer than usual is only 33, and it’s possible he picks up his career elsewhere. There aren’t too many remaining Patriots Regimes in the wild in 2025, but Nick Caserio does still run the Texans and they let Jon Weeks walk this offseason so that’s one speculative fit.
NewOrleans.Football’s Nick Underhill said he would be “flabbergasted” if Derek Carr played for the Saints this year.
“I would have trouble understanding why you would allow that to happen, you’re trying to build a new culture, you can’t let that guy ... you just got a rookie QB, this is the example you’re going to give him,” Underhill continued. Both Underhill and Mike Triplett believe Tyler Shough will be starting for the Saints in Week 1, with Underhill saying he had “80 percent or higher odds to start 80 percent of the games this year.” Shough would be an uninspiring superflex pick, perhaps a QB3, but given how things have played out with Carr over the past months it sure doesn’t seem like the Saints have a reason to want to continue this relationship. Mickey Loomis literally asked reporters to stop asking him Carr questions at his pre-draft press conference.