NFL Best Bets For Seahawks vs. Lions: Picks, Predictions & Player Props

Two NFL games on Monday night means twice the amount of football, twice the excitement and twice the opportunity to win some money with our NFL best bets for Seahawks vs. Lions MNF.
The second game, Seattle Seahawks versus the Detroit Lions, kicks off at 8:15pm ET, is an exciting match-up and we are ready to start diving into our NFL predictions. As always, it is important to check in with the Vegas odds & lines to track any potential line movement.
We will also check in with any relevant historical data before making our NFL picks, project the potential game-flow and we’ll be ready with another round of our NFL best bets for Seahawks vs. Lions MNF.
NFL Picks, Predictions & Best Bets For Monday Night Football, 9/30
There is a surprisingly strong amount of recent data between these two teams, but the question we have to ask is how relevant it might be for our NFL predictions as the Seahawks have a new head coach and offensive coordinator.
Nevertheless, these two teams have met three times in the last two seasons, twice in Detroit, and the Seahawks are 3-0 straight-up and 2-1 against the spread. In fact, over their last 10 games against each other, the Seahawks are 9-1 straight-up and 7-3 against the spread. With regard to the game total, the over is 6-4 over their last 10 meetings with the over massively hitting in each of the last three. But how much of this do we bake into our NFL picks?
The Seahawks have had a bit of a transformation while the Lions have made some improvements on defense but remain relatively the same on offense. Let’s dive into some game flow before finalizing our NFL best bets for Seahawks vs. Lions MNF.
Monday Night Football Prediction: Monday, September 30th
When we look at the Detroit Lions offense, we have to begin with the ground game. Head coach Dan Campbell is an old-school guy and absolutely adores his 1-2 punch of David Montgomery and Jahmyr Gibbs.
But the Seahawks defense ranks third in DVOA against the run, and they’ve allowed an average of just 116.3 rushing yards per game. They also rank second in DVOA against running back pass-plays so even if you’re looking for Gibbs as a pass-catcher, things could get rough.
Of course, things don’t get much easier for the Lions through the air as Seattle ranks first in DVOA against the pass. They allow the fewest passing yards per game at 132.3 and their defensive backs, Riq Woolen, Tre Brown and Devon Witherspoon are some of the best in the game.
Detroit’s top receiver, Amon-Ra St. Brown, takes 58-percent of his snaps from the slot which puts him and Witherspoon at odds with each other and that’s a tough task for someone even at St. Brown’s level.
For Seattle, Ryan Grubb’s offense has really started to take shape over the last two weeks. Yes, they looked fine against Denver in Week 1, but over these last two weeks, we’ve seen the misdirection and precision-passing we had been expecting after watching countless hours of video of his offense from the University of Washington.
Geno Smith has a 75.5-percent completion percentage over the last two games with an average of 303 passing yards with one touchdown per game. His top target, as expected, has been DK Metcalf who is coming off back-to-back 100-yard efforts and has scored in each of those games.
But in order for Seattle’s passing attack to truly take flight, they need to establish the ground game as well. Kenneth Walker returns from an oblique injury, but he’s got a tough task here against the Lions defensive line and overall run defense. The Lions rank fourth in DVOA against the run and have allowed an average of just 76.7 rushing yards per game.
We might see Seattle utilize a 1-2 punch of their own with Walker and Zach Charbonnet just to try and soften that line with some fresh legs. So, we’ve got the strengths and we’ve got the weaknesses of these two teams. Do we have enough to finalize our NFL picks and set up our NFL best bets for Seahawks vs. Lions MNF? Yes, we do.
Seahawks vs. Lions Best Bet: Monday, September 30th
This line actually opened at Lions -6 and dropped down as low as 3.5 points. Looking at the line right now, it’s Lions -4 and considering the recent history, we could be looking at a road dog here.
Seattle’s offensive line, which has been banged-up, is going to be routinely tested by a tough Lions pass-rush, but I absolutely love this passing attack for them. If Seattle’s run defense holds and we put our faith in these corners, then even at home, Jared Goff could struggle.
- Pick: Seahawks +4 (-110 on BetMGM Sportsbook)
Considering the strength of each team’s run defense, we’re expecting both passing attacks to be featured in this one. While the Lions pass-rush is strong and the Seattle defensive backs are some of the best, I expect to see some points scored in this one.
Seattle has averaged 24 points per game while the Lions have averaged just over 20. Just one extra push from either team pushes the over which should hit for the fourth-straight time in this series.
- Pick: Over 46.5 (-110 on BetMGM Sportsbook)
Best NFL Player Prop Bets & Other Picks Today, 9/30
- Jaxon Smith-Njigba Over 4.5 Receptions (-115 on BetMGM Sportsbook)
- DK Metcalf Over 61.5 Receiving Yards (-115 on BetMGM Sportsbook)
- Jahmyr Gibbs Anytime TD (-110 on BetMGM Sportsbook)
**Please check back for more and/or different props as lines are still being posted as of writing this.
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Player News
49ers signed No. 11 pick EDGE Mykel Williams to a four-year contract.
The deal is worth $24.9 million and is fully guaranteed. As is the case with all first-round picks, his contract includes a fifth-year option. The 49ers shed hundreds of millions of dollars in contracts this offseason and the bulk of those savings came on the defensive side of the ball. Defensive end was an obvious position of need and Williams was widely regarded as the best pass-rusher on the board when 49ers GM John Lynch was on the clock. Williams totaled five sacks in 2024 and left Georgia with 14 sacks across three seasons as a starter.
Vikings signed No. 24 pick OG Donovan Jackson to a four-year contract.
It’s a fully guaranteed deal worth $17.2 million with a fifth-year team option. Minnesota taking Jackson with the 24th-overall pick came as a bit of a surprise on draft night, but the Vikings needed offensive line help and Jackson was considered worthy of a first-round pick by some draftniks. He was primarily a left guard at Ohio State but successfully kicked out to tackle for the bulk of his senior season. Jackson is likely fated for guard duties in Minnesota, but the positional versatility remains a plus.
Titans claimed Anfernee Orji off waivers from the Saints.
Orji played primarily on special teams in New Orleans but was credited with two starts across 16 appearances. He totaled 30 combined tackles and a pair of TFLs. Orji will need to continue seeing work on special teams to make the Titans’ roster.
Patriots signed RB Trayveon Williams, formerly of the Bengals.
Henderson was passed on the Cincinnati depth chart by Chase Brown last year and the team even traded for Khalil Herbert midseason. Despite having no role on offense, Williams was active for all 17 games as a special teamer. He will likely hold a similar role in New England if he cracks the team’s 53-man roster.
Free agent RB Jordan Mims worked out for the Patriots.
The Pats also worked out former Bengals running back Trayveon Williams. Mims ran 20 times for 70 yards in 2024 while adding 12 catches for 71 yards through the air. He also got some run on special teams. The Patriots are looking for some extra depth at running back, but there isn’t room for another fantasy-relevant option behind Rhamondre Stevenson and TreVeyon Henderson.
Jaguars signed TE Quintin Morris, formerly of the Bills, to a one-year contract.
Morris is purely a blocking tight end. He caught just 15 passes during his three years with the Bills, though he did manage to find the end zone three times. Morris will back up Brenton Strange in Jacksonville.