Colts vs. Packers Predictions, Picks & Odds: NFL Week 2, Sunday 9/15

One of the biggest storylines of the Week 1 slate unfortunately happened early on with Green Bay Packers QB Jordan Love going down with an MCL injury. The Cheeseheads will look to bounce back from that season-opening loss at home against the Indianapolis Colts, and we’ve broken down the matchup to provide you with our best Colts vs. Packers predictions.
Even if you already have Colts vs. Packers picks in mind, you’ll also find the details for a guaranteed $250+ DraftKings Sportsbook promo after our best bets, so you’ll be set up regardless!
Colts vs. Packers Predictions for NFL Week 2, Sunday, 9/15
The NFL has been taken over by young QBs over the past few seasons, and two would have been featured in this matchup. Love went down in Brazil against the Philadelphia Eagles, and while the timetable given for his return was 3-4 weeks, Green Bay head coach Matt LaFleur has made things a bit interesting.
By not placing him on IR, they have not only left him available for this Sunday in that regard, but they have also done so verbally. To be clear, we absolutely do not expect him to suit up, but the Pack are certainly being coy about the situation. Either way, we should be in for a great interconference clash with the Colts nearly taking down the Houston Texans in Week 1.
Indianapolis Colts: Coming Back From A Close Call
Indy was at home for their Week 1 AFC South rivalry with the Texans but were three-point underdogs. However, not only did they cover that key-number spread, but they nearly pulled off the outright upset.
That will be something to note as we get into the top picks from our Colts vs. Packers predictions, but as for Indy specifically, we understand why they are now favored in Week 2. The loss of Love is a significant one for Green Bay, especially with how Colts young QB Anthony Richardson looked last week. The #4 overall pick two drafts ago was the team’s leading rusher and accounted for three total touchdowns.
Green Bay Packers: Learning To Live Without Love
We know that it’s been talked about more than some fans would even prefer, but the elephant in the room simply cannot be avoided. Love truly proved himself the second half of last season, and the team certainly bought in.
Until Cowboys QB Dak Prescott’s contract signing just hours before kickoff on Sunday, Love was tied as the highest-paid player in the NFL, despite still having plenty of critics. Now, the team will rely on backup QB Malik Willis, who had been with the Tennessee Titans. He brings a dual-threat element under center, which is one that Indy will now have to prepare for.
Colts vs. Packers Odds, Spreads, Total & Betting Lines
Below, you’ll see the latest Colts vs. Packers odds at DraftKings Sportsbook, where we found the best value for our best bet:
- Point Spread: Indianapolis Colts -3 (-105) vs. Green Bay Packers +3 (-115)
- Money Line: Indianapolis Colts (-148) vs. Green Bay Packers (+124)
- Game Total (Over/Under): Over 40.5 (-112) vs. Under 40.5 (-108)
Colts vs. Packers Point Spread: Green Bay +3 (-115 at DraftKings Sportsbook)
Not only does the Love injury have the Packers as home underdogs, but it also dropped the point total down to one of the lowest that we’ve seen throughout the entire first two weeks of the season. If anything, we’d suggest adding the over to your Colts vs. Packers picks.
However, we’re still going to take Green Bay on the point spread as our best bet. This seems to be a bit of an overreaction to the Love injury, especially given that the Packers will be the ones with a significant rest advantage. Since they played on Friday Night Football in Week 1, they’ll have those extra couple of days.
Green Bay was also in control of much of that FNF game against the Eagles, taking a lead into halftime and holding on late into the third quarter. Unfortunately for the Cheesehead faithful, Philly’s big offseason splash of RB Saquon Barkley came to fruition to the tune of three touchdowns.
This week, we expect the Packers new RB Josh Jacobs to be the one to turn things up. Frankly, he already looked great in Week 1, and we just saw Indy allow RB Joe Mixon to go for 159 yards and a touchdown, which made him the top at his position in fantasy football in the opening weekend.
With that in mind, the best bet from our Colts vs. Packers predictions is on Green Bay +3 (-115 at DraftKings Sportsbook).
Colts vs. Packers Injury Report & Latest News
Now that you have the latest Colts vs. Packers odds and best bet from our Colts vs. Packers predictions, here are the players to keep an eye on in terms of injuries:
IND Colts:
- S Julian Blackmon (Questionable)
- DT DeForest Buckner (Questionable)
- WR Josh Downs (Questionable)
- DE Kwity Paye (Questionable)
GB Packers:
- CB Corey Ballentine (Questionable)
- DL Kenny Clark (Questionable)
- RB Josh Jacobs (Questionable)
- RB MarShawn Lloyd (Questionable)
- LB Quay Walker (Questionable)
- QB Jordan Love (Doubtful)
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Player News
Dolphins signed No. 13 overall pick DT Kenneth Grant to a four-year contract.
ESPN’s Jeremy Fowler reports that Grant will sign his contract today. The former Michigan defensive tackle is expected to fill a major void left by Christian Wilkins, who left for the Raiders in the 2024 offseason. Grant totaled 32 tackles, three sacks, and seven TFLs in his final season at Michigan and excelled at stopping the run while also generating 27 pressures in his final season, per PFF.
Beat reporter John Hendrix reports that free agent WR Donovan Peoples-Jones is among the 16 players that the Saints will host for their rookie minicamp.
Peoples-Jones last played regular season snaps with the Lions back in 2023, when he caught 13-of-24 targets for 155 yards. He is highly unlikely to return to fantasy relevance at this point but could perhaps sign on as a special teams contributor.
Titans signed fourth-round pick WR Elic Ayomanor to a four-year contract.
Ayomanor will now begin learning behind Calvin Ridley. Although Ayomanor is unlikely to find a meaningful role in year one, dynasty managers should note his status as training camp gets underway this summer. The former Stanford receiver flashed big-play ability in his two college seasons.
Buccaneers signed seventh-round pick WR Tez Johnson to a four-year contract.
Johnson will serve as a rotational deep-threat option for Baker Mayfield. His thin frame (5'10/154) simply does not lend itself to the repeated hits one incurs in a full-time role. Johnson did earn 100-plus targets in his two seasons at Oregon, though. His big-play style make him a better fit in best ball for now, pending any major on-field breakthroughs.
Giants waived DT Casey Rogers.
Rogers was a 2024 undrafted free agent and logged 33 defensive snaps for the Giants in his rookie season. He is credited with zero tackles and/or sacks. He may find his way onto another roster as a practice squad option.
Vikings signed third-round pick WR Tai Felton to a four-year contract.
Felton is quietly in play to challenge Vikings No. 3 WR Jalen Nailor in training camp. Nailor (5'11/190) caught 28-of-42 targets for 414 yards and six touchdowns in his first season as a starter last year, with the latter category buoying his fantasy productivity. Felton (6'1/183), meanwhile, caught 96-of-143 targets for 1,119 yards and nine touchdowns while averaging 2.32 yards per route run in his final college season. Fantasy managers should monitor Felton’s training camp reports this summer, as he could have a matchup-based WR5 role if everything falls into place.