The old AFC East regime meets the new this Sunday with the Buffalo Bills hosting the New England Patriots. The Bills have had the division clinched for a decent while now, but with this classic rivalry, we’re still here to provide our best Patriots vs. Bills predictions for the Week 16 matchup.

We’ve even found value with a best bet to help you lock in your Patriots vs. Bills picks, which will all be more valuable courtesy of the newest FanDuel Sportsbook sign up bonus that we have for you!

 

 

 

Patriots vs. Bills Predictions For NFL Week 16, Sunday 12/22

Last Sunday was a perfect exemplification of how the tides have turned in the AFC East over the past handful of seasons. The Pats frankly never looked competitive against the Arizona Cardinals, while the Bills snapped the Detroit Lions 11-game winning streak in what could have been a Super Bowl preview.

Therefore, to no one’s surprise, the Patriots vs. Bills odds have Buffalo as an absolutely massive favorite. Don’t be surprised to see Bills QB Josh Allen have his Superman cape on once again, as we’re fully predicting him to show off his dual-threat ability given New England giving up two rushing touchdowns and a TE to have nine catches for 87 yards.

With such significant lines in the standard markets, we used everything we could from recent results to provide you with the top pick from our Patriots vs. Bills predictions coming up!
 

 

 

New England Patriots: Already Coaching Concern?

After moving on from future Hall-of-Fame head coach Bill Belichick, the Patriots hired a former player in Jerod Mayo to lead the team. The overall feeling of that move seemed quite positive by fans and analysts alike. That was especially the case after upsetting the Cincinnati Bengals as nearly double-digit underdogs in Week 1.

Well, a lot has changed since then, and despite not even having a full year under his belt, there are already rumblings of Mayo not being the man for the job. They certainly aren’t as loud as say Dallas Cowboys head coach Mike McCarthy, but they’re happening nonetheless. Finding a way to upset the juggernaut that is the Bills would certainly silence them for at least a while.
 

 

 

Buffalo Bills: Getting Over The Hump

Speaking of being a juggernaut, QB Josh Allen and the Bills have been among the AFC favorites for a few years now, but never quite getting over the hump. Even when they’ve looked like the best team in the league, they have always hit a roadblock, which has often been the same one.

That would, of course, be the Kansas City Chiefs. However, they did hand the Chiefs their lone loss this season, but Buffalo is still a game behind in terms of earning that #1 overall seed in the conference. That’s scary news for Pats fans, as it means that the Bills have no reason to let up despite being a massive favorite.
 

 

 

Patriots vs. Bills Odds, Spreads, Total & Betting Lines

Just how much of a massive favorite is Buffalo? Here are the latest Patriots vs. Bills odds at DraftKings Sportsbook:

 

 

Patriots vs. Bills Best Bet: James Cook Over 14.5 Carries (-114 at FanDuel Sportsbook)

Anytime we see such a significant favorite on the point spread, it can be extremely difficult to target that betting market, especially in the NFL. On top of that, divisional rivalries generally tend to be more difficult to handicap. Therefore, we’re going to focus our Patriots vs. Bills predictions on the prop markets.

Our approach may surprise you, as it’s been all about Allen being Superman and finding ways to score both with his arm and using his legs. There is no denying that he’s a fantastic runner, and we actually expect him to put that on display this Sunday. While that may be the case, it doesn’t mean that the true RB James Cook should be overlooked.

Based on this weekend’s line, we believe that oddsmakers are indeed overlooking him. Even with Allen taking over games, Cook has had 14 carries in two of the last three games. Similarly, prior to this gauntlet of a four-game stretch for the Bills, Cook had double-digit carries in every game but one this season, including three with 19 or more.

With Buffalo being such a huge favorite, they will likely have an entire quarter or more of just running out the clock, and there is no reason to further jeopardize Allen’s health. Therefore, the best bet from our Patriots vs. Bills predictions is James Cook over 114.5 carries (-114 at FanDuel Sportsbook).
 

 

 

Patriots vs. Bills Injury Report & Latest News

As far as injury concerns go for this AFC East rivalry, Buffalo’s concerns mostly lie on the defensive side of the ball but aren’t ones that are incredibly significant. They saw WR Keon Coleman and TE Dalton Kincaid get healthy recently, which is a huge boost. New England is quite healthy themselves, but as with every week, it’s important to keep track of the NFL injury report at Fantasy Alarm.

 

 

 

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