Last week featured the longest NFL road trip with Miami heading up to Seattle, but this week isn’t far behind with the New England Patriots going cross-country to visit the San Francisco 49ers. This matchup has the biggest point spread of the week, but we’ve still found our favorite way to approach the game with our Patriots vs. 49ers predictions.

Even if you decide to go a different route than the best bet from our Patriots vs. 49ers picks, we’ll share how you can bet on anything and claim a FanDuel Sportsbook sign up bonus for a $200 boost guaranteed!

 

 

 

Patriots vs. 49ers Predictions For NFL Week 4, Sunday 9/29

Traveling across the country isn’t the only thing going against the Pats this week. They’re coming off a brutal loss to a division rival on national TV with the New York Jets flying through them 24-3.

Now, that was on Thursday Night Football, so they’ll at least have the rest advantage in this matchup. However, will that make a difference against the team that just represented the NFC in the Super Bowl last year? Well, the 49ers are dealing with massive injury issues and are coming off back-to-back losses themselves.

So much going on with both teams can absolutely make locking Patriots vs. 49ers predictions difficult. Not to worry - we’ve found a rather specific market that we love.

 

 

 

New England Patriots: Figuring Out Their Identity

Before we fully get into the best bet from our Patriots vs. 49ers predictions, let’s discuss each team a bit more first. The Pats opened up the season knocking off the Cincinnati Bengals as the biggest underdogs of the week on the road, which is the exact spot they find themselves in this Sunday.

It was a huge win, but with the Bengals now at 0-3, how big of a win was it? We know that their identity resides on the defensive side of the ball, but even that is quite imbalanced. They’ve been strong against the run, but weak against the pass. So, it’s up to San Fran head coach Kyle Shanahan to find ways to exploit that.
 

 

 

San Francisco 49ers: Piecing Things Together

The reason that we’re putting the pressure on Shanahan rather than specific players is because up until now, he’s had the superstars to rely on. That has since changed, as not only is RB Christian McCaffrey still missing, but so is WR Deebo Samuel.

We saw WR Jauan Jennings emerge last week, but now that teams can gameplan for that, it’s on Shanahan to scheme him open alongside WR Brandon Aiyuk. Of course, RB Jordan Mason has quickly made a name for himself, and this run defense may be his toughest test to date.

 

 

 

Patriots vs. 49ers Odds, Spreads, Total & Betting Lines

As far as the standard markets go, here are the latest Patriots vs. 49ers odds at FanDuel Sportsbook:

 

 

Patriots vs. 49ers Point Spread: San Fran First Half Team Total Over 13.5 (-110 at FanDuel Sportsbook)

With a banged-up 49ers squad being such a massive favorite, we’re not touching such a significant point spread. We also don’t know if we can trust the Pats to keep things close, hence our rather specific approach.

Our Patriots vs. 49ers predictions are focused on just the San Francisco side as well as just the first half of the game. We anticipate a victory for the 49ers, but we want to avoid a backdoor cover situation with the game in hand. So, we’re eyeing a fast start for the red and gold.

After all, that’s how they’ve been looking thus far. Last week, they allowed a huge comeback from the Los Angeles Rams to fall 27-24 after blowing a 21-7 lead. That is the exact situation we want to avoid, so let’s just focus on cashing by halftime.

In two of San Francisco’s first three games, they’ve gone over this first half total, including 14 first-quarter points in Week 1. That has them within the top 10 in terms of first-half points per game, and while the Pats’ defense is better than their offense, they’re still only middle-of-the-pack when it comes to first-half points allowed per game.

We just saw the Jets score 14 in the first two quarters against New England, and the week prior was the Seattle Seahawks putting up 17 first-half points. Even with some missing pieces, we trust San Francisco to go over 13.5 first-half points (-110 at FanDuel Sportsbook) with our Patriots vs. 49ers predictions.
 

 

 

Patriots vs. 49ers Injury Report & Latest News

We’ve mentioned quite a few players when going through our Patriots vs. 49ers predictions, and here are those with injury concerns following Thursday’s practice:

NE Patriots:

SF 49ers:

 

 

How To Bet On Patriots vs. 49ers at FanDuel Sportsbook & Claim Your $200 Bonus

Even if you want to take a different approach than our Patriots vs. 49ers predictions, we’ve still got a way for you to do so with a guaranteed $200 FanDuel bonus, and here’s how:

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