Commanders vs. Cardinals Predictions, Picks & Odds: NFL Week 4, Sunday 9/29
It’s a smaller late afternoon slate for Week 4, but one of the four games features what is quite a long trip on a short week for the Washington Commanders heading out to Arizona to take on the Cardinals. Both teams have been far more competitive than many anticipated before the season, and we’ve got our Commanders vs. Cardinals predictions as they go head-to-head.
Along with the best bet from our Commanders vs. Cardinals, picks will be a guaranteed $200 DraftKings Sportsbook welcome offer, so we’ve got you covered for a great weekend overall!
Commanders vs. Cardinals Predictions for NFL Week 4, Sunday 9/29
Don’t look now, but the Commanders are trying to take command of the NFC East! It’s certainly a bit early to go that far, but in the final game of Week 3, they were the ones to send the Cincinnati Bengals to 0-3 on Monday Night Football.
You may see the Cards at 1-2 behind a 3-0 division leader, but don't let that fool you. They played a strong game against an NFC favorite in the Detroit Lions last Sunday, which came after a crushing 41-10 win and a tight 34-28 loss to the Buffalo Bills in Week 1.
Keep those scores in mind as we advance to the best bet from our Commanders vs. Cardinals predictions, but more about each team first.
Washington Commanders: Daniels Dashing Through Expectations
There are all kinds of reasons why Washington entered this 2024-25 campaign with low expectations, one of which was beginning the year with a rookie QB under center. Although Jayden Daniels was the #2 overall pick, there was still concern that the LSU product was simply too small.
Well, he began the season proving doubters wrong with his legs and following the recent MNF performances against a fellow LSU QB Joe Burrow, he did so with his arm. Apparently, Daniels needs no adjustment period to the NFL, as he became just the second rookie in NFL history to record a passing and rushing TD on Monday Night Football.
Arizona Cardinals: Not Getting Discouraged
As mentioned, Arizona is coming off a tough defeat at the hands of the Detroit Lions. However, they have looked far stronger than most fans anticipated before the start of the season, and they need to focus on that rather than their 1-2 record.
In fact, they very well could be sitting at 3-0, or at the very least 2-1. They lost to the Lions last week by a touchdown but had a pick-six called back because the refs decided to give a very generous two-minute warning timeout to Detroit. In Week 1, Arizona even had a 17-3 lead over the Bills, who look like the best team in the NFL right now!
Commanders vs. Cardinals Odds, Spreads, Total & Betting Lines
The best bet from our Commanders vs. Cardinals predictions is actually one of our best bets for the entire slate overall, but first, the latest Commanders vs. Cardinals odds at DraftKings Sportsbook:
- Point Spread: Washington Commanders +3.5 (-120) vs. Arizona Cardinals -3.5 (+100)
- Money Line: Washington Commanders (+142) vs. Arizona Cardinals (-170)
- Game Total (Over/Under): Over 50.5 (-108) vs. Under 50.5 (-112)
Commanders vs. Cardinals Predictions: Over 50.5 Points (-108 at DraftKings Sportsbook)
We know that the total of the Commanders vs. Cardinals odds is quite high - in fact, it’s the highest of the entire Week 4 slate. Even still, we don’t think that it’s high enough. We’re expecting a 28-24 type of game in either direction, which is also why we don’t want to focus our Commanders vs. Cardinals predictions on a point spread hovering around three.
Even that final score would pale in comparison to the Commanders’ showdown on MNF just a handful of nights ago. They put up 38 on the Bengals, while also allowing Cinci to put up 35 themselves. As dynamic as Daniels has made their offense, their defense continues to struggle giving up explosive plays.
Specifically, their passing defense - which was dead last in the NFL last year - continues to look rough. Well, the Cards have put rookie WR Marvin Harrison on full display, and a healthy QB Kyler Murray has proven that he can still get the job done.
That makes it two of the biggest dual-threat QBs in one matchup, so not only are we expecting plenty of points, but in exciting fashion. Lastly, Arizona and Washington rank fourth and sixth for the best over record, respectively, since the start of last season, so the best bet from our Commanders vs. Cardinals predictions is over 50.5 points (-108 at DraftKings Sportsbook).
Commanders vs. Cardinals Injury Report & Latest News
As with any matchup, make sure that you have the latest injury news, and here is the latest from Thursday’s practice:
WAS Commanders:
- RB Austin Ekeler - DNP
- DE Clelin Ferrell - DNP
- WR Jamison Crowder - DNP
- CB Benjamin St-Juste - LP
- RG Sam Cosmi - LP
ARI Cardinals:
- TE Trey McBride - DNP
- DL Khyiris Tonga - DNP
- OL Kelvin Beachum - LP
- WR Marvin Harrison - LP
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Player News
Dolphins signed No. 13 overall pick DT Kenneth Grant to a four-year contract.
ESPN’s Jeremy Fowler reports that Grant will sign his contract today. The former Michigan defensive tackle is expected to fill a major void left by Christian Wilkins, who left for the Raiders in the 2024 offseason. Grant totaled 32 tackles, three sacks, and seven TFLs in his final season at Michigan and excelled at stopping the run while also generating 27 pressures in his final season, per PFF.
Beat reporter John Hendrix reports that free agent WR Donovan Peoples-Jones is among the 16 players that the Saints will host for their rookie minicamp.
Peoples-Jones last played regular season snaps with the Lions back in 2023, when he caught 13-of-24 targets for 155 yards. He is highly unlikely to return to fantasy relevance at this point but could perhaps sign on as a special teams contributor.
Titans signed fourth-round pick WR Elic Ayomanor to a four-year contract.
Ayomanor will now begin learning behind Calvin Ridley. Although Ayomanor is unlikely to find a meaningful role in year one, dynasty managers should note his status as training camp gets underway this summer. The former Stanford receiver flashed big-play ability in his two college seasons.
Buccaneers signed seventh-round pick WR Tez Johnson to a four-year contract.
Johnson will serve as a rotational deep-threat option for Baker Mayfield. His thin frame (5'10/154) simply does not lend itself to the repeated hits one incurs in a full-time role. Johnson did earn 100-plus targets in his two seasons at Oregon, though. His big-play style make him a better fit in best ball for now, pending any major on-field breakthroughs.
Giants waived DT Casey Rogers.
Rogers was a 2024 undrafted free agent and logged 33 defensive snaps for the Giants in his rookie season. He is credited with zero tackles and/or sacks. He may find his way onto another roster as a practice squad option.
Vikings signed third-round pick WR Tai Felton to a four-year contract.
Felton is quietly in play to challenge Vikings No. 3 WR Jalen Nailor in training camp. Nailor (5'11/190) caught 28-of-42 targets for 414 yards and six touchdowns in his first season as a starter last year, with the latter category buoying his fantasy productivity. Felton (6'1/183), meanwhile, caught 96-of-143 targets for 1,119 yards and nine touchdowns while averaging 2.32 yards per route run in his final college season. Fantasy managers should monitor Felton’s training camp reports this summer, as he could have a matchup-based WR5 role if everything falls into place.