It’s a smaller late afternoon slate for Week 4, but one of the four games features what is quite a long trip on a short week for the Washington Commanders heading out to Arizona to take on the Cardinals. Both teams have been far more competitive than many anticipated before the season, and we’ve got our Commanders vs. Cardinals predictions as they go head-to-head.

Along with the best bet from our Commanders vs. Cardinals, picks will be a guaranteed $200 DraftKings Sportsbook welcome offer, so we’ve got you covered for a great weekend overall!

 

 

 

Commanders vs. Cardinals Predictions for NFL Week 4, Sunday 9/29

Don’t look now, but the Commanders are trying to take command of the NFC East! It’s certainly a bit early to go that far, but in the final game of Week 3, they were the ones to send the Cincinnati Bengals to 0-3 on Monday Night Football.

You may see the Cards at 1-2 behind a 3-0 division leader, but don't let that fool you. They played a strong game against an NFC favorite in the Detroit Lions last Sunday, which came after a crushing 41-10 win and a tight 34-28 loss to the Buffalo Bills in Week 1. 

Keep those scores in mind as we advance to the best bet from our Commanders vs. Cardinals predictions, but more about each team first. 
 

 

 

Washington Commanders: Daniels Dashing Through Expectations

There are all kinds of reasons why Washington entered this 2024-25 campaign with low expectations, one of which was beginning the year with a rookie QB under center. Although Jayden Daniels was the #2 overall pick, there was still concern that the LSU product was simply too small.

Well, he began the season proving doubters wrong with his legs and following the recent MNF performances against a fellow LSU QB Joe Burrow, he did so with his arm. Apparently, Daniels needs no adjustment period to the NFL, as he became just the second rookie in NFL history to record a passing and rushing TD on Monday Night Football.  

 

 

 

Arizona Cardinals: Not Getting Discouraged

As mentioned, Arizona is coming off a tough defeat at the hands of the Detroit Lions. However, they have looked far stronger than most fans anticipated before the start of the season, and they need to focus on that rather than their 1-2 record.

In fact, they very well could be sitting at 3-0, or at the very least 2-1. They lost to the Lions last week by a touchdown but had a pick-six called back because the refs decided to give a very generous two-minute warning timeout to Detroit. In Week 1, Arizona even had a 17-3 lead over the Bills, who look like the best team in the NFL right now! 
 

 

 

Commanders vs. Cardinals Odds, Spreads, Total & Betting Lines

The best bet from our Commanders vs. Cardinals predictions is actually one of our best bets for the entire slate overall, but first, the latest Commanders vs. Cardinals odds at DraftKings Sportsbook:

 

 

Commanders vs. Cardinals Predictions: Over 50.5 Points (-108 at DraftKings Sportsbook)

We know that the total of the Commanders vs. Cardinals odds is quite high - in fact, it’s the highest of the entire Week 4 slate. Even still, we don’t think that it’s high enough. We’re expecting a 28-24 type of game in either direction, which is also why we don’t want to focus our Commanders vs. Cardinals predictions on a point spread hovering around three.

Even that final score would pale in comparison to the Commanders’ showdown on MNF just a handful of nights ago. They put up 38 on the Bengals, while also allowing Cinci to put up 35 themselves. As dynamic as Daniels has made their offense, their defense continues to struggle giving up explosive plays.

Specifically, their passing defense - which was dead last in the NFL last year - continues to look rough. Well, the Cards have put rookie WR Marvin Harrison on full display, and a healthy QB Kyler Murray has proven that he can still get the job done.

That makes it two of the biggest dual-threat QBs in one matchup, so not only are we expecting plenty of points, but in exciting fashion. Lastly, Arizona and Washington rank fourth and sixth for the best over record, respectively, since the start of last season, so the best bet from our Commanders vs. Cardinals predictions is over 50.5 points (-108 at DraftKings Sportsbook).

 

 

 

Commanders vs. Cardinals Injury Report & Latest News

As with any matchup, make sure that you have the latest injury news, and here is the latest from Thursday’s practice:

WAS Commanders:

ARI Cardinals:

 

 

How To Bet On Commanders vs. Cardinals At DraftKings Sportsbook & Claim Your $200 Bonus

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