Week 4 of the NFL season didn’t feature a single NFC West rivalry game, but they’re back on the menu this Sunday! We’ve got the San Francisco 49ers remaining at home to host the Arizona Cardinals, both of which are trailing the Seattle Seahawks in the division. As they try to gain ground, we’ve shared our best Cardinals vs. 49ers predictions with you.

Along with the best bet from our Cardinals vs. 49ers picks will be a FanDuel Sportsbook sign up bonus that provides a guaranteed $200 boost to your account!

 

 

 

Cardinals vs. 49ers Predictions For NFL Week 5, Sunday 10/6

After scoring 28+ points in each of their first two games and nearly starting 2-0, there was all sorts of optimism surrounding the Cardinals. On the flip side, after losing two straight games after their season-opening win, there was some worry by the Bay.

Since then, both teams have begun to shift back towards expectations, which is a mediocre team for Arizona and a Super Bowl contender for the 49ers. Even still, divisional rivalries nearly always bring hard-fought matchups, which can make locking in Cardinals vs. 49ers predictions even more difficult.

Not to worry - we found a great spot that we love, so let’s discuss each team a bit further so that we can get into our best bet following the latest Cardinals vs. 49ers odds. 
 

 

 

Arizona Cardinals: Figuring Out Their Identity

Before we fully get into the best bet from our Cardinals vs. 49ers predictions, let’s discuss each team a bit more first. The Pats opened up the season knocking off the Cincinnati Bengals as the biggest underdogs of the week on the road, which is the exact spot they find themselves in this Sunday.

It was a huge win, but with the Bengals now at 0-3, how big of a win was it? We know that their identity resides on the defensive side of the ball, but even that is quite imbalanced. They’ve been strong against the run, but weak against the pass. So, it’s up to San Fran head coach Kyle Shanahan to find ways to exploit that.
 

 

 

San Francisco 49ers: Piecing Things Together

The reason that we’re putting the pressure on Shanahan rather than specific players is because up until now, he’s had the superstars to rely on. That has since changed, as not only is RB Christian McCaffrey still missing, but so is WR Deebo Samuel.

We saw WR Jauan Jennings emerge last week, but now that teams can gameplan for that, it’s on Shanahan to scheme him open alongside WR Brandon Aiyuk. Of course, RB Jordan Mason has quickly made a name for himself, and this run defense may be his toughest test to date.
 

 

 

Cardinals vs. 49ers Odds, Spreads, Total & Betting Lines

We used the latest Cardinals vs. 49ers odds at FanDuel Sportsbook for good reason - to provide you with the best value - and here are the latest lines:

 

 

Cardinals vs. 49ers Point Spread: Arizona First Half +4.5 (-110 at FanDuel Sportsbook)

If anything, taking the Cards to keep it within a touchdown would be another play to add to your Cardinals vs. 49ers picks, especially if we see it tick to 7.5 points. However, we’re going to isolate the first half, especially given that interesting line.

Normally, sportsbooks simply cut values in half, which largely makes sense. For example, the first half spread would generally be 3.5 points, just as the first half total would be around 24.5 points (which it is). So, grabbing the Cardinals +4.5 in the first half is value-based purely on numbers.

Aside from just that fact is that Arizona is being quite devalued after a very bad loss to the Washington Commanders. There’s no denying that, but San Francisco hasn’t been as dominant as expected either. They blew two double-digit leads against the Los Angeles Rams, and beating the New England Patriots at home last weekend is far from anything to write home about.

We also saw the Cards dominate the Buffalo Bills in the first half of their opening game, which is a team that is among the best in the NFL right now. Let’s also not forget that Arizona smashed the same Rams team that San Fran lost to by a final score of 41-10. That was an LA team that had historically owned them, making it even more impressive.

Even if Arizona isn’t able to pull off an outright upset, we love them +4.5 in the first half (-110 at FanDuel Sportsbook), which is the best bet from our Cardinals vs. 49ers predictions.
 

 

 

Cardinals vs. 49ers Injury Report & Latest News

San Francisco has been among the most banged-up teams so far this season, so we’ve got you covered with the Thursday injury report for both teams below:

ARI Cardinals:

SF 49ers:

 

 

How To Bet On Cardinals vs. 49ers at FanDuel Sportsbook & Claim Your $200+ Bonus

Now that you’ve got our Cardinals vs. 49ers predictions under your belt and even more, let’s go through your guaranteed $200 FanDuel sign up bonus - it takes just a few steps!

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