Cardinals vs. 49ers Predictions, Picks & Odds: NFL Week 5, Sunday 10/6
Week 4 of the NFL season didn’t feature a single NFC West rivalry game, but they’re back on the menu this Sunday! We’ve got the San Francisco 49ers remaining at home to host the Arizona Cardinals, both of which are trailing the Seattle Seahawks in the division. As they try to gain ground, we’ve shared our best Cardinals vs. 49ers predictions with you.
Along with the best bet from our Cardinals vs. 49ers picks will be a FanDuel Sportsbook sign up bonus that provides a guaranteed $200 boost to your account!
Cardinals vs. 49ers Predictions For NFL Week 5, Sunday 10/6
After scoring 28+ points in each of their first two games and nearly starting 2-0, there was all sorts of optimism surrounding the Cardinals. On the flip side, after losing two straight games after their season-opening win, there was some worry by the Bay.
Since then, both teams have begun to shift back towards expectations, which is a mediocre team for Arizona and a Super Bowl contender for the 49ers. Even still, divisional rivalries nearly always bring hard-fought matchups, which can make locking in Cardinals vs. 49ers predictions even more difficult.
Not to worry - we found a great spot that we love, so let’s discuss each team a bit further so that we can get into our best bet following the latest Cardinals vs. 49ers odds.
Arizona Cardinals: Figuring Out Their Identity
Before we fully get into the best bet from our Cardinals vs. 49ers predictions, let’s discuss each team a bit more first. The Pats opened up the season knocking off the Cincinnati Bengals as the biggest underdogs of the week on the road, which is the exact spot they find themselves in this Sunday.
It was a huge win, but with the Bengals now at 0-3, how big of a win was it? We know that their identity resides on the defensive side of the ball, but even that is quite imbalanced. They’ve been strong against the run, but weak against the pass. So, it’s up to San Fran head coach Kyle Shanahan to find ways to exploit that.
San Francisco 49ers: Piecing Things Together
The reason that we’re putting the pressure on Shanahan rather than specific players is because up until now, he’s had the superstars to rely on. That has since changed, as not only is RB Christian McCaffrey still missing, but so is WR Deebo Samuel.
We saw WR Jauan Jennings emerge last week, but now that teams can gameplan for that, it’s on Shanahan to scheme him open alongside WR Brandon Aiyuk. Of course, RB Jordan Mason has quickly made a name for himself, and this run defense may be his toughest test to date.
Cardinals vs. 49ers Odds, Spreads, Total & Betting Lines
We used the latest Cardinals vs. 49ers odds at FanDuel Sportsbook for good reason - to provide you with the best value - and here are the latest lines:
- Point Spread: Arizona Cardinals +7 (-105) vs. San Francisco 49ers -7 (-115)
- Money Line: Arizona Cardinals (+295) vs. San Francisco 49ers (-370)
- Game Total (Over/Under): Over 49.5 (-110) vs. Under 49.5 (-110)
Cardinals vs. 49ers Point Spread: Arizona First Half +4.5 (-110 at FanDuel Sportsbook)
If anything, taking the Cards to keep it within a touchdown would be another play to add to your Cardinals vs. 49ers picks, especially if we see it tick to 7.5 points. However, we’re going to isolate the first half, especially given that interesting line.
Normally, sportsbooks simply cut values in half, which largely makes sense. For example, the first half spread would generally be 3.5 points, just as the first half total would be around 24.5 points (which it is). So, grabbing the Cardinals +4.5 in the first half is value-based purely on numbers.
Aside from just that fact is that Arizona is being quite devalued after a very bad loss to the Washington Commanders. There’s no denying that, but San Francisco hasn’t been as dominant as expected either. They blew two double-digit leads against the Los Angeles Rams, and beating the New England Patriots at home last weekend is far from anything to write home about.
We also saw the Cards dominate the Buffalo Bills in the first half of their opening game, which is a team that is among the best in the NFL right now. Let’s also not forget that Arizona smashed the same Rams team that San Fran lost to by a final score of 41-10. That was an LA team that had historically owned them, making it even more impressive.
Even if Arizona isn’t able to pull off an outright upset, we love them +4.5 in the first half (-110 at FanDuel Sportsbook), which is the best bet from our Cardinals vs. 49ers predictions.
Cardinals vs. 49ers Injury Report & Latest News
San Francisco has been among the most banged-up teams so far this season, so we’ve got you covered with the Thursday injury report for both teams below:
ARI Cardinals:
- Isaiah Adams - DNP
- Matt Prater - DNP
- Garrett Williams - DNP
- Christian Jones - LP
- Khyiris Tonga - LP
- Kelvin Beachum - LP
SF 49ers:
- Chris Conley - DNP
- Jacob Cowing - DNP
- Yetur Gross-Matos - DNP
- George Kittle - DNP
- Fred Warner - DNP
- Demetrius Flannigan-Fowles - DNP
- Kevin Givens - LP
- Talanoa Hufanga - LP
- Dee Winters - LP
- Isaac Yiadom - LP
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Player News
Packers signed WR Bo Melton, RB Emanuel Wilson, and P Daniel Whelan to their exclusive rights free agent tenders.
Melton caught on with the Packers in 2023, totaling 16 receptions for 218 yards and a touchdown in five games. He added eight receptions for 91 yards in 17 games last season. Melton will continue to be a depth piece in an already-deep Packers wide receiver room. Wilson has also been with the Packers for two seasons and rushed for 502 yards and four touchdowns as Josh Jacobs’ immediate backup last season. He will compete with MarShawn Lloyd for that role again. Whelan is the team’s punter and will be back for 2025. All three signed their exclusive rights free agent tender and will essentially be on one-year contracts this season.
Seahawks re-signed Johnathan Hankins to a one-year contract.
Hankins hasn’t had a PFF run defense grade above 52.4 since 2020 and is primarily called on to play early downs. He turned 33 in March. He’ll be a complimentary piece behind Jarran Reed and Byron Murphy II if he makes the roster out of training camp.
Chargers placed the UFA tender on RB J.K. Dobbins.
This gives the Chargers exclusive negotiating rights if he does not sign with a team by July 22 or the first 2025 NFL training camp opens, whichever comes first. The tag is mainly useful for compensatory pick reasons as Dobbins will still count towards Los Angeles’ haul in the formula if signed before then. The Chargers currently do not project to add a pick in 2026 per Over The Cap’s Nick Korte.
49ers signed OT D.J. Humphries.
Humphries played in only two games for the Chiefs last year as he spent most of the season rehabbing a late 2023 torn ACL on his own. He wasn’t appreciably good in either of those games, but he was rusty and does have a history of better than that. Entering his age-32 season for the 49ers, he’ll probably be trying to win the right tackle job opposite Trent Williams in training camp.
Patriots released LS Joe Cardona.
The team selected his replacement, Julian Ashby, in the seventh round of the draft. This snapper of balls who are longer than usual is only 33, and it’s possible he picks up his career elsewhere. There aren’t too many remaining Patriots Regimes in the wild in 2025, but Nick Caserio does still run the Texans and they let Jon Weeks walk this offseason so that’s one speculative fit.
NewOrleans.Football’s Nick Underhill said he would be “flabbergasted” if Derek Carr played for the Saints this year.
“I would have trouble understanding why you would allow that to happen, you’re trying to build a new culture, you can’t let that guy ... you just got a rookie QB, this is the example you’re going to give him,” Underhill continued. Both Underhill and Mike Triplett believe Tyler Shough will be starting for the Saints in Week 1, with Underhill saying he had “80 percent or higher odds to start 80 percent of the games this year.” Shough would be an uninspiring superflex pick, perhaps a QB3, but given how things have played out with Carr over the past months it sure doesn’t seem like the Saints have a reason to want to continue this relationship. Mickey Loomis literally asked reporters to stop asking him Carr questions at his pre-draft press conference.