Welcome into tonight’s MLB best bets for this slate of MLB action here at Fantasy Alarm on this Friday, May 16th, 2025! Happy Friday everyone you all made it! Your reward is a full slate of games tonight and checking out my picks below, good luck and have an awesome weekend!

In this MLB Best Bets Today article, you will find a wide array of choices, from some Money Lines to game totals and, on occasion, some player props! Check out the rationale, and if you agree with me, make sure to tail and good luck!

Now, let's dive into my expert MLB Best Bets today!

  • Season Record: 81-60-4
  • Bankroll: +10.2 units

Follow me on twitter @jwaggs10

 

 

 

MLB Picks, Predictions & Best Bets Today, 5/16

Nationals vs. Orioles Predictions

The Beltway series is back underway again tonight as the Nats head to the Inner Harbor to take on the Orioles. There are a few angles to make wagers on in this matchup, but I’ll say off the top that the Nationals are in a favorable spot against Cade Povich on the mound. Povich straight up can’t get right-handed batters out this season, allowing a .322 average and .927 OPS against the opposite side of the plate, and this makes the Nationals appealing even without CJ Abrams and James Wood on the right side of the splits. 

On top of that, the Orioles are facing an uphill battle against MacKenzie Gore, the Nationals' ace who has been feeling himself this season. He has 62 strikeouts over the last 46.2 innings pitched and has kept his ERA down to just under 4 during that timespan as well. The Orioles do have bats that could challenge him, but as a team, they just aren’t putting the ball in play enough to produce consistently. Their K-rate of 25.4% is the 7th highest in MLB, and their BABIP of .232 is the lowest in the entire league. 

Add it all up and it looks like the Nationals are going to have to upper hand to start the series, and I will be loading up on them on the Money Line, and I will take Gore to go over his strikeouts tonight as well. 

Pick: Nationals Money Line (+110 on DraftKings)

Pick: MacKenzie Gore (WSH) Over 6.5 Strikeouts (-105 on DraftKings)

 

 


 

Best MLB Prop Bets & Other Picks Today, 5/16

Pick: Red Sox Money Line (-115 on DraftKings)

Pick: Corbin Carroll (ARI) Over 2.5 Hits/Runs/RBIs (-110 on DraftKings)

Pick: Jackson Merrill (SD) Over 2.5 Hits/Runs/RBIs (+120 on DraftKings)

Pick: Texas Rangers Run Line -1 (-130 on DraftKings)