Lions vs. Colts Predictions, Picks & Odds: NFL Week 12, Sunday 11/24

Yet again, the Detroit Lions are coming off an absolute dominant performance and will be looking to continue their hot streak in relatively nearby Indianapolis against the Colts. As we prepare for this NFC vs. AFC clash, we’ve broken down our Lions vs. Colts predictions and top pick for you.
Whether you end up rolling with the best bet from our Lions vs. Colts picks or see something else that catches your eye, we’ll also provide you with a huge $1,500 BetMGM Sportsbook new user offer to enjoy using any betting market!
Lions vs. Colts Predictions For NFL Week 12, Sunday 11/24
Overall Lions vs. Colts predictions? Detroit winning yet again. As great as it would be for things to be that easy, that is far from the case. Any team can beat any other team on any given Sunday, but we don’t see Indy getting in the way of this Dan Campbell-led freight train.
The highest total a team has reached this season is 52, which has been the Lions - twice. That came in a similar situation last Sunday against an AFC South team. While they will be on the road this time around, they’ll be back in a dome, so they can treat it just like Ford Field if they’d like.
Detroit actually isn’t as big of a favorite as they were last week despite a 52-6 victory, and we’re going to use that to our advantage for the top pick from our Lions vs. Colts predictions.
Detroit Lions: Roaring Through The NFC
Before we fully get into our favorite approach for Lions vs. Colts picks, let’s outline each team in this interconference clash. It’s one that may end up being between two playoff teams, but it’s certainly not Detroit that is leaving that in question.
There was speculation as to whether or not they could be true Super Bowl contenders after superstar pass rusher Aidan Hutchinson went down for the season, but they quickly silenced those doubts. Sitting at 9-1 and on an eight-game winning streak, they are the clear favorites to represent the NFC in the Super Bowl this February.
Indianapolis Colts: Richardson Rolls
While the Colts have work to do for their right to get into the postseason, a win here would get them back to .500 with a 6-6 record. It hasn’t been without drama, though - second-year QB Anthony Richardson was benched in lieu of 39-year-old QB Joe Flacco.
After back-to-back losses led by Flacco, the team once again turned to Richardson this past Sunday, who absolutely showed why he was drafted with the #4 overall pick two offseasons ago. He ran for two scores in a very close 28-27 win over the New York Jets, which led to them firing their general manager on Tuesday morning.
Lions vs. Colts Odds, Spreads, Total & Betting Lines
Keep the above score in mind as we start breaking down the best bet from our Lions vs. Colts predictions, but first, the latest Lions vs. Colts odds at BetMGM Sportsbook:
- Point Spread: Detroit Lions -7.5 (-110) vs. Indianapolis Colts +7.5 (-110)
- Money Line: Detroit Lions (-375) vs. Indianapolis Colts (+300)
- Game Total (Over/Under): Over 50.5 (-110) vs. Under 50.5 (-110)
Lions vs. Colts Teaser: Detroit -1.5 & Over 44.5 (-120 at BetMGM Sportsbook)
As you can see, our favorite Lions vs. Colts picks come in the form of a teaser. This is a way for us to modify the lines in our favor, and while they both need to come to fruition, we are supremely confident in them doing so.
We saw the Lions as 11-point favorites on the road last weekend, and boy did they cover. They routed the Jacksonville Jaguars to the tune of 52-6, and it wasn’t just the final score that has us believing that they will do the same this weekend.
Head coach Dan Campbell never let his foot off the gas. Even when they were up 42-6, he had all his starters in the game, AND threw the ball for explosive plays. Whether it’s to pad QB Jared Goff’s stats to build his MVP resume or just to instill fear in other teams, the fact remains that Campbell is making a statement.
Superstar WR Amon-Ra St. Brown was the touchdown scorer in the fourth quarter to make it 49-6, so they truly never let up. With the Colts allowing the seventh-most passing yards per game, there’s no reason for us to think that Goff won’t have another MVP-caliber performance in Indy.
The Colts have also proven that they love these shootouts, as we noted to remember their 28-27 win just this past weekend. When they played Detroit’s opponent from last Sunday - the Jags - it was yet another shootout with a 37-34 final score. Even if Indy isn’t able to exploit a weak Lions secondary (sixth-most passing yards per game), Detroit has proven multiple times that they can cover the total themselves.
Along with Campbell’s crew being 8-2 against the spread this season, we love targeting Detroit -1.5 and over 44.5 points (-120 at BetMGM Sportsbook) as our best Lions vs. Colts picks.
Lions vs. Colts Injury Report & Latest News
We know that Aidan Hutchinson won’t be seeing the field again this season, and we’ve already seen Richardson return from his injury and benching. Other noteworthy players that often find themselves dealing with ailments are Colts RB Jonathan Taylor and Lions RB Jahmyr Gibbs. So, be sure to always be in the know with the latest NFL injury report from Fantasy Alarm.
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Player News
Free agent Gabe Davis will visit the New York Giants.
Cut by the Jaguars after one season last week, Davis visited the 49ers on Monday. New York would be a reunion of sorts, as he played for Giants coach Brian Daboll in Buffalo. The G-Men already have several wideouts capable of stretching the field, but 26-year-old Davis could still be a decent role player in a strong offense. The problem, of course, is that the Giants profile as anything but, but rookie QB Jaxson Dart is comfortable throwing down the field.
Ravens S Ar’Darius Washington has been diagnosed with a torn achilles suffered during offseason training.
The fifth-year pro became a weekly starter for the first time last season, earning elite PFF marks in the process. He was a restricted free agent this spring but had yet to sign his $3.26 million tender. That’s a tough break, to put it mildly. Achilles timelines have shortened significantly in recent years, but Washington will probably still miss the entire 2025 campaign. The Ravens are protected in part by their first-round selection of fellow S Malaki Starks, but May is not the month you already want to be dipping into your depth. Going on 26, Washington’s career future is murky after he worked so hard to finally become a regular contributor last season.
Chiefs signed fourth-round WR Jalen Royals to a four-year contract.
Royals doesn’t have an obvious and open spot in the receiving corps to build short-term fantasy value with Xavier Worthy, Hollywood Brown, and Rashee Rice operating in the opening 11-personnel package. He may or may not play his way into WR4 duties depending on how the team feels about JuJu Smith-Schuster. Royals has plenty of talent and Brown is on a one-year deal, so there is a future where Royals is more than a bit player for the Chiefs. It likely won’t happen in his first season without injuries in front of him.
Matthew Judon said he “probably” won’t return to the Falcons in 2025.
The Falcons, of course, drafted both Jalon Walker and James Pearce in the first round. In an exclusive interview with CardPlayer.com — not to be confused with our PokerNews.com James Cook scoop a few days ago — Judon said that his sack total was down because “I dropped (into coverage) on 60 percent of the plays. It’s hard to get a pick and a sack on the same play.” Judon also told Kyle Odegard that “a couple” teams had expressed interest in him but he was in no rush to sign.
Jets released P Thomas Morstead.
Austin McNamara and Kai Kroeger will compete for the Jets punter job this year. The 39-year-old former Saint was the league’s oldest punter last season. If he wants to keep punting, he can absolutely join the tryout circuit or a competition elsewhere. But this is probably a sign that the Morstead’s 16-year career is close to an end at this point.
Lions offensive coordinator John Morton said it’s “going to be a breakout year” for Jameson Williams.
Morton said he’d never “been around someone that fast,” then quickly corrected himself to note that Jhamyr Gibbs is also that fast. Williams came on strong last year with a 58/1001/7 receiving line, but offensive coordinator praise could mean even more targets are coming. It would likely come at the expense of Amon-Ra St. Brown’s production if Williams were to truly break out, though there’s plenty for St. Brown to give and still be a top-flight fantasy wideout. It’s risky to read too much into statements like this in the offseason, but the new offensive coordinator telling you he thinks it’ll be a breakout year for Williams is certainly noteworthy.