The most lopsided division in the NFL is the AFC East with the Buffalo Bills sitting 7-2 ahead of the next-best team with just a 3-6 record. They’ll be looking to extend that division lead on the road this Sunday against an Indianapolis Colts team looking to get back to a .500 record. To get you set for the AFC battle, we’ve broken down our top Bills vs. Colts predictions.

After going through each team’s storylines and our best bet, we’ve got a guaranteed $200 BetMGM Sportsbook sign up bonus for you, even if you have your own Bills vs. Colts picks!

 

 

 

Bills vs. Colts Predictions For NFL Week 10, Sunday 11/10

Outside of their blowout loss to the Baltimore Ravens, it was almost as if the Bills had hardly been tested this season. That changed this past Sunday, as a healthier Miami Dolphins team pushed them to the brink in a tight 30-27 win.

We provided a teaser of Buffalo +3 and over 40.5 points for that matchup, as the Bills continue to make us look good. As for Indy, their run defense continues to struggle, so look for this to be a game where Buffalo QB Josh Allen looks to build on his MVP resume with some highlight scrambles.

Overall, however, we’re predicting that both teams will look to control the ball and grind things out, which is a factor for the top pick from our Bills vs. Colts predictions.
 

 

 

Buffalo Bills: Building Their AFC Resume

While Allen is building upon his resume for MVP on an individual basis, he is also trying to convince fans and analysts alike that the Bills are the biggest threat to the Kansas City Chiefs in the AFC. Of course, their 25-point loss to the Ravens is the glaring weakness of that argument.

Even still, Buffalo is undoubtedly one of the top teams in the conference looking to get over the hump. That roadblock has been QB Patrick Mahomes and the Chiefs in the postseason, not to mention their hatred for the old playoff overtime rules. Either way, winning games they are expected to win is a must to silence their doubters. 
 

 

 

Indianapolis Colts: Wacko For Flacco…Still

We referenced the Bills recent win over the Dolphins, who Indy also played this season. That was a 16-10 win for the Colts, but of course, that was without Miami QB Tua Tagovailoa under center.

While common opponents are great to have, it’s difficult to label them as such given that major factor. That was the Colts last win as well, as they’ve now dropped back-to-back games amidst their QB drama with second-year signal caller Anthony Richardson having recently been benched.

They are yet again going with the seasoned veteran Joe Flacco, who continues to defy Father Time and keep Indy relevant at the very least.
 

 

 

Bills vs. Colts Odds, Spreads, Total & Betting Lines

Despite being on the road, the Bills are still clear favorites this Sunday, which comes as a surprise to virtually no one. Below, you can see the latest Bills vs. Colts odds at BetMGM Sportsbook:

 

 

Bills vs. Colts Teaser: Under 48 Points (-110 at BetMGM Sportsbook)

It’s worth noting that road favorites have been on fire this season, especially since Week 5. So, if you want to back Buffalo in that regard with your Bills vs. Colts picks, we certainly wouldn’t fault you.

However, while the Colts may be just 4-5 in the win-loss column, they are a remarkable 7-2 against the spread this season. So, that causes some hesitation in riding the road favorite trend, and there is another trend that is important to note.

Indy isn’t just polarizing in terms of ATS record - they also have the second-best record in terms of over/unders. That may come as a surprise given the poor run defense that we mentioned earlier, but it hasn’t been enough to let teams light up the scoreboard. While they allow the second-most rushing yards per game, they’re in the top half of the league in terms of rushing touchdowns allowed.

While the Colts had some high-scoring games early in the year, each of their last four games have finished with 43 points or fewer, with three of them completing with 37 or fewer. That’s well below the total set for this Sunday, making us even more confident in our Bills vs. Colts predictions.

Buffalo also allows just a tick over 19 points per game, so we’re locking in our best bet on the under 48 points (-110 at BetMGM Sportsbook). 
 

 

 

Bills vs. Colts Injury Report & Latest News

From Buffalo RB James Cook to Indy RB Jonathan Taylor both having suffered injuries this season, even key players in this matchup need to be monitored. Therefore, keep track of the NFL injury report from our very own Fantasy Alarm crew to help with your Bills vs. Colts picks.
 

 

 

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