And just like that, NFL Week 3 is here and it's time to talk Thursday Night Football best bets and player props. The New York Giants are coming off a fantastic come-from-behind victory over the Arizona Cardinals last week, but step into the lion's den as they now travel to San Francisco to take on Brock Purdy, Christian McCaffrey and the rest of the 49ers. It's an extremely tough match-up for Big Blue what with Saquon Barkley and the left side of their offensive line being out, but we've got a double-digit point-spread here and that can be difficult to navigate. Fortunately, we don't actually have to bet the game line because there are a ton of great player props to look at as well. No further need for pleasantries, so let's get to it.

 

NFL Thursday Night Football Best Bets: New York Giants vs San Francisco 49ers

The Spread: 49ers -10.5

Not gonna lie – I hate this spread. I hate everything about it. The Giants are missing half od their offensive line and there’s no Saquon Barkley, but laying 10.5-points in the NFL is a tough place to be. I believe the 49ers control this game for most of the way, but do they build up a strong enough lead to withstand a potential back-door cover when they’ve taken their foot off the gas? That’s really my biggest issue. We saw Daniel Jones sling the rock against the Cardinals during that huge comeback, but this 49ers pass defense is substantially better, not to mention the pass-rush is one of the best in the game. I probably won’t bet the spread myself and just stick to the game total and the props, but if I had to make a pick right now…

Pick: 49ers -10.5

The Total: 44

The fact that I am taking the 49ers to cover the spread means I don’t believe in the Giants offense. I think they have trouble moving the ball up and down the field with any kind of consistency and I think the 49ers start to gradually extend a lead they won’t relinquish. Even if/when they take their foot off the gas, I don’t know how much a road-weary and battered Giants team does against a defense that is just looking to close out the game. A lopsided game like this usually has me leaning towards…

Pick: Under 43.5

Favorite Thursday Night Football Player Props:

**all odds courtesy of DraftKings Sportsbook