NFL SNF Best Player Prop Picks: 49ers vs. Bills - Sunday, 12/1

After sharing our best NFL player prop picks for the Thanksgiving and Black Friday action, we’ve got another prime time game to enjoy with Sunday Night Football between the San Francisco 49ers and Buffalo Bills. So, of course, we also have our best NFL SNF player prop picks for you!
To add some additional value to our 49ers vs. Bills player props, we’ll also take you through a fantastic FanDuel Sportsbook sign up bonus for multiple rewards!
Best NFL Sunday Night Football Player Prop Picks
There is no doubt that NFL SNF player prop picks will be a popular approach for this matchup with how many variables and moving parts are involved. What was once one of the most likely Super Bowl matchups now has one of the most significant point spreads of the entire Week 13 slate.
Not only do many fans prefer not to target such markets, but there are several key injuries at play. They are primarily with the 49ers - QB Brock Purdy, OT Trent Williams AND DE Nick Bosa. Even the Bills have concerns with TE Dalton Kincaid and WR Keon Coleman. However, understanding how these injuries affect the rest of the team can make NFL SNF player prop picks even more valuable.
We’re going to be focusing on the QBs in this NFC vs. AFC clash, so let’s break down our best 49ers vs. Bills player props.
49ers vs. Bills Player Props: Josh Allen Anytime TD Scorer (+135 at FanDuel Sportsbook)
First up for our NFL SNF player prop picks is the QB with no question marks heading into this matchup. Not only is that the case for Buffalo QB Josh Allen, but he’s also one of the MVP frontrunners!
As we’ve all seen by now, that’s thanks to his dominance both with arguably the strongest arm in the NFL and his incredible running ability. The latter is what we’re focused on to provide you with some plus-money odds.
Firstly, if we don’t see Bosa back on the field, that would certainly be ideal, but even if he is back, the 49ers defense simply hasn’t been what we’ve seen the past few seasons. Specifically, they’ve been allowing teams to find the endzone on the ground on a regular basis. They’ve done so in each of their past six games, including multiple with 2+ rushing TDs allowed.
That also includes allowing the Dallas Cowboys to score a rushing touchdown, who has the worst run offense in the NFL. While Allen may not technically be an RB, he’s still one of the best rushers in the league. Therefore, we’re starting our NFL SNF player prop picks with Josh Allen to score an anytime touchdown (+135 at BetMGM Sportsbook).
49ers vs. Bills Player Prop Bets: Brock Purdy Over 0.5 Interceptions at FanDuel Sportsbook
Next up for our NFL SNF player prop picks is the other QB in this matchup. Now, we mentioned the Purdy injury concern, and while he was limited at practice this week, the hope is for him to be back on the field for such a crucial game.
If for some reason it isn’t Purdy, we’d still suggest the same addition to our 49ers vs. Bill player props, as the Buffalo defense has simply been fantastic in this department. There will likely be some extra juice with a backup QB, but it should be worth the squeeze.
The Bills’ secondary was looking questionable given that they lost nearly the entire unit this offseason, but they have picked up right where they left off. Their 13 interceptions this season are the fourth-most in the NFL, and let’s not forget about another one of San Francisco’s injury concerns.
Star LT Trent Williams is also questionable, which means more pressure on whichever QB is under center. Of course, that leads to forced quicker throws and more likely turnover opportunities. While we need to monitor the line for this portion of our NFL SNF player prop picks, we still love Brock Purdy to throw an interception with expected odds of around -120 at FanDuel Sportsbook.
Sunday Night Football Player Props At FanDuel Sportsbook
To add on to our best NFL SNF player prop picks, here are some other popular 49ers vs. Bills player props at FanDuel Sportsbook:
Passing Yards:
- Josh Allen: Over 228.5 (-114) vs. Under 228.5 (-114)
Rushing Yards:
- Christian McCaffrey: Over 61.5 (-114) vs. Under 61.5 (-114)
- James Cook: Over 60.5 (-114) vs. Under 60.5 (-114)
Receiving Yards:
- Deebo Samuel: Over 76.5 (-114) vs. Under 76.5 (-114)
- George Kittle: Over 41.5 (-114) vs. Under 41.5 (-114)
- Amari Cooper: Over 76.5 (-114) vs. Under 76.5 (-114)
- Khalil Shakir: Over 41.5 (-114) vs. Under 41.5 (-114)
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Player News
Panthers released TE Jordan Matthews.
Matthews converted to tight end a few years ago and hasn’t made much noise at the position. The change has, however, likely kept him in the league for a few more seasons. He appeared in four games with the Panthers last year but didn’t record any stats on offense. The Panthers also released or waived WR Dax Milne, C Andrew Raym, and TE Colin Granger.
Dolphins released LS Blake Ferguson.
The team also waived CB Ryan Cooper Jr., DT Neil Farrell and OL Chasen Hines. Ferguson has been the team’s long snapper for five seasons and earned a three-year contract extension just before the 2023 season. He should be able to find work snapping footballs farther than the average snap elsewhere in the league.
DetroitLions.com’s Tim Twentyman believes rookie WR Isaac TeSlaa “could make his earliest impact on special teams.”
It’s not much of a surprise, as most rookies cut their teeth with special teams duties. Twentyman mentioned return duties as a possibility, though the former Razorback never returned kicks or punts in college. At 6'4/212 with 4.43 wheels, TeSlaa is an explosive athlete who never translated his physical traits to on-field production at Arkansas. The Lions clearly saw potential for him to do so in the pros and traded two future third-round picks to move up to No. 70 overall for him. It’s going to be a slow burn for TeSlaa in the pros, making him a dynasty-only fantasy option.
Vikings head coach Kevin O’Connell said the team does not “have any feelings on competition” when asked about the quarterback room.
O’Connell was asked about a potential quarterback competition on the Rich Eisen Show Wednesday and was unclear on whether J.J. McCarthy would have to compete to start. He said, “we’ve got an obligation as coaches to put our players in position to attack that competition phase.” O’Connell discussed first putting Brett Rypien and the newly acquired Sam Howell in a position to play before any competition would occur. He continued that McCarthy is “owning it” this offseason and is taking snaps from starting center Ryan Kelly. After missing last season with a torn meniscus, McCarthy has been ramping up workouts in the offseason and is the front-runner to start for the Vikings in 2025. As of now, Howell looks to be reinforcement at the backup spot in case it turns out McCarthy is not ready to start.
Texans re-signed DT Foley Fatukasi.
Fatukasi initially joined the Texans last offseason on a one-year contract. The 30-year-old was a rotational defensive lineman, tallying four tackles for loss and one sack. He returns to Houston for 2025, where he will be a part of a deep Texans front seven.
NFL Network’s Tom Pelissero reports Tyreek Hill’s second wrist surgery was part of the original plan and his timeline remains unchanged.
Hill announced the second surgery on social media and Pelissero quickly added some context to the situation. The speedy receiver suffered the wrist injury just before the start of the season and it lingered throughout the year, though he never missed a game because of it. If the second surgery truly is a non-story, an offseason to recover might be what Hill needs to return to form after a down 2024 season. On the other hand, Hill is 31 years old, played his worst football last year, and his offense prioritized targets for Jonnu Smith and De’Von Achane. As it stands, Hill might have the highest risk-reward split in fantasy drafts.