NFL MNF Best Player Prop Picks: Lions vs. 49ers - Monday, 12/30

What was supposed to be a potential, if not likely, NFC Championship Game between the Detroit Lions and San Francisco 49ers is no longer, as the latter has been eliminted from playoff contention. However, it’s still a prime time Monday Night Football game to enjoy, which is why we’ve got our best NFL MNF player prop picks for you.
We’ll also provide other Lions vs. 49ers player props that you could consider targeting, and it all goes along with the generous $1,500 BetMGM Sportsbook welcome offer that we have for you!
Best NFL Monday Night Football Player Prop Picks
If there was ever a matchup between two teams all but defined by injuries, it would be the Lions and 49ers. That alone can make locking in the best NFL MNF player prop picks difficult, not to mention how these teams have performed through these injuries.
Although Detroit is the one with the most players on injured reserve in the entire NFL, they are the ones sitting at 13-2 and fighting for the #1 overall seed in the NFC. Meanwhile, after entering the year as the NFC favorites, San Francisco can’t even make the postseason, let alone a top seed.
Even with all that into account, we’ve got a point spread of around a field goal for the matchup, which is why we’ve found NFL MNF player prop picks to enjoy as an alternative.
Lions vs. 49ers Player Props: Jameson Williams Longest Reception Under 22.5 Yards (-115 at BetMGM Sportsbook)
Last week against the Chicago Bears, we targeting Detroit RB Jahmyr Gibbs to go over his carries prop, which he did with 23 of them. That was the first game following the injury to RB David Montgomery, which is why we trusted him to be a true bell cow.
Something else we targeted was Miami Dolphins RB DeVon Achane to find the endzone against the 49ers last Sunday, which he did. Having said all that, we expect Gibbs to find the endzone as well, but given the price, we’d suggest finding a way to pair that with something, such as Detroit’s money line.
For better value, we are instead going to focus on the passing game. This one may cause some hesitation as there is no denying that Williams is an explosive play waiting to happen. However, that has also caused this line to finally get inflated to a point where we have a spot to take an under.
If there is one thing that the 49ers have still been able to do well, it’s prevent explosive plays. They rank third in term of average depth of reception at just 6.6 yards per catch. While we saw Williams have a signature deep catch last Sunday, the Bears rank second-worst for those types of plays.
It may be a bit of a sweat, but we’re comfortable starting our NFL MNF player prop picks with Jameson Williams’ longest reception under 22.5 yards (-115 at BetMGM Sportsbook).
Lions vs. 49ers Player Prop Bets: Deebo Samuel Over 4.5 Receptions (+100 at BetMGM Sportsbook)
To continue our NFL MNF player prop picks, we’re going to stay in the passing game, but with the San Francisco side of the matchup. As incredible as Detroit has been this season, if they have a fatal flaw, it’s their pass defense.
Specificaly, how they’re performed about versatile WRs. That’s important to note because when it comes to the 49ers offense, it’s Samuel and TE George Kittle that eat up most of the targets. However, the Lions have been absolutely phenomenal against the TE position, allowing the absolute fewest fantasy points to them this year.
On the flip side, Detroit’s defense has allowed the sixth-most passing yards allowed per game AND sixth-most fantasy points to the WR position. On top of all that is the most important part and why we’re targeting this market - they have allowed the second-most receptions to WRs this season.
So, while the 49ers always want to get Kittle involved, Samuel had the same number of targets (nine) as Kittle last Sunday with just one fewer catch (seven). It’s also very clear that the team wants to get the ball into Deebo’s hands as much as possible given their mounting injuries, as he was also given five carries.
With it being how to try and exploit the Detroit defense, we’re adding to our NFL MNF player prop picks with Deebo Samuel over 4.5 receptions (+100 at BetMGM Sportsbook).
Monday Night Football Player Props At BetMGM Sportsbook
Feel free to lock in more Lions vs. 49ers player props alongside our best NFL MNF player prop picks with some of the popular lines at BetMGM Sportsbook:
Passing Yards:
- Jared Goff: Over 250.5 (-115) vs. Under 250.5 (-115)
- Brock Purdy: Over 250.5 (-115) vs. Under 250.5 (-115)
Rushing Yards:
- Jahmyr Gibbs:: Over 54.5 (-115) vs. Under 54.5 (-115)
- XXX: Over 89.5 (-115) vs. Under 89.5 (-115)
Receiving Yards:
- Amon-Ra St. Brown: Over 39.5 (-115) vs. Under 39.5 (-115)
- Jameson Williams: Over 46.5 (-115) vs. Under 46.5 (-115)
- Deebo Samuel: Over 41.5 (-115) vs. Under 41.5 (-115)
Anytime TD Scorer:
- Jahmyr Gibbs: -450
- Amon-Ra St. Brown: -150
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Player News
The Commanders will play the Dolphins in Madrid, Spain on November 16.
The NFL appears keen on spotlighting Jayden Daniels and the Commanders after their stunning run to the NFC title game last season. Daniels will lead the hyper-efficient Washington offense into Madrid for the last of the seven 2025 international regular season games. It could be an exciting back-and-forth affair between a high-powered Commanders offense — now with Deebo Samuel — and a Miami offense led by Tua Tagovailoa, De’Von Achane, and Tyreek Hill.
The Vikings in 2025 will have back-to-back international games in different countries.
They will be the first team to play back-to-back weeks in different countries outside the United States. The Vikings will face off against the Steelers in the first-ever NFL regular season game in Dublin on Stepember 28, then play the Browns in London the following weekend. It could be a tough travel schedule for the Vikings, though the Jaguars have played back-to-back international games in recent years. Those games were in the same country, however. The Vikings-Steelers game could be intriguing if Aaron Rodgers is under center for Pittsburgh after trying and failing to generate interest for his services in Minnesota this offseason.
The Athletic’s Ted Nguyen believes Cowboys WR George Pickens could see a “huge uptick” in single coverage this season.
Pickens, who was traded from the Steelers to the Cowboys last week in exchange for draft pick compensation, won’t function as the primary wideout in Dallas. Pickens’ ability to challenge secondaries deep is something the Cowboys have “sorely missed” in recent seasons, Nguyen said. “In Pittsburgh, opposing defenses often doubled Pickens or shaded a safety to his side,” he said. “With the Cowboys, if defenses choose to put a safety over the top of Pickens, Lamb will have more space to work with in the middle of the field. You would expect teams to continue doubling Lamb, which means Pickens could see a huge uptick in one-on-one coverage.” Pickens, according to Nguyen, will only improve the Dallas passing attack if he gives consistent effort. The moody Pickens became widely known for taking plays off — and sometimes giving little effort for an entire game — during his three years with the Steelers. More single coverage, however, could mean more explosive plays for the new Cowboys WR2. In the Steelers’ run-first scheme last season, Pickens was third in targets of more than 20 yards downfield and second in receiving yards on downfield receptions. Pickens had just one drop on 30 downfield looks in 2024.
ESPN’s Jeremy Fowler reports Saints hosted free agent CB Asante Samuel for a visit Monday.
Samuel, fresh off offseason neck surgery, visited with the Saints Monday as he pursues his next playing opportunity. He has clear connection to the franchise after they hired Brandon Staley to fill their defensive coordinator position, for whom Samuel played under with the Chargers. Fowler adds that Samuel has another doctor visit scheduled for early July, during which time he hopes to gain clearance to resume football activities.
ESPN’s Adam Schefter reports Packers met with WR Jayden Reed’s agent, Drew Rosenhaus, to clarify his status with the team.
The meeting comes after the Packers selected a wide receiver in the first round for the first time since 2002 in this year’s draft. Schefter added that the team emphasized Reed’s status as the top option at wide receiver after the selection of Matthew Golden and Savion Williams. “Green Bay’s top receiver” means far less for fantasy than it does in other places around the league considering Reed led the team with just 62.6% of the team’s offensive snaps played in 2024. Reed in 2024 accounted for 16 percent of the Packers’ targets and 16 percent of the team’s air yards. He was targeted on just 19 percent of his pass routes after seeing a target on 23.4 percent of his routes in 2023.
Saints signed QB Hunter Dekkers.
Dekkers spent three seasons with the Cyclones of Iowa State before stepping away from football following an indictment surrounding charges related to sports gambling. He then played his final collegiate season at Iowa Western before being invited to Saints camp. Dekkers spent his redshirt season backing up Brock Purdy at Iowa State.