Welcome back to another round of MLB Best Bets Today as the 2025 baseball season rolls on. 

Saturday’s slate is jam-packed with 17 games on the baseball schedule. We have every team in action and a pair of doubleheaders on tap as we target winning MLB predictions and picks. We’ll focus on two games for our MLB best bets today before dishing out a few baseball player props to consider. 

Keep in mind, some of these odds or lines could move before first pitch. All bets below are for one unit unless otherwise noted. Without further ado, let’s dive into our MLB Best Bets Today.

 

 

 

MLB Picks, Predictions & Best Bets Today, 4/26

Our MLB Best Bets Today start with a late-night matchup between the San Diego Padres and Tampa Bay Rays. Can Dylan Cease anchor the home Padres to cash our MLB picks?

We’ll also dive into the Cincinnati Reds vs. Colorado Rockies afternoon showdown from Coors Field. Check out the MLB predictions to make as you enjoy Saturday’s baseball action. 

 

 

 

Rays vs. Padres Predictions: Saturday, April 26th

In today’s Rays vs. Padres game, we have one pitcher to fade and one pitcher to buy low on. It’s an interesting interleague matchup that could go either way. Yet, the starting pitchers and respective offenses all point to the home squad. 

Padres starter Dylan Cease has an ugly 6.05 ERA this season, but he’s primed for positive regression. The right-hander’s 2.62 FIP and 3.36 xERA are much more respectable, while his 26.5% K rate (71st percentile) and 31.3% chase rate (74th) are encouraging. He’s also been unlucky, based on a high .384 BABIP and low 56.8% left-on-base rate 

Cease’s inflated ERA is largely due to one terrible outing when he coughed up nine runs to the Athletics on the road – in a hitter-friendly park, no less. Otherwise, he boasts a 2.95 ERA across his four other starts this season. Plus, he’s allowed two earned runs or fewer in three of his last four outings coming into the weekend. 

We should see Cease limit the Rays at home tonight. He had a 3.03 ERA and 2.82 FIP at home last year in San Diego’s pitcher-friendly environment. Meanwhile, Tampa’s offense has been notably worse on the road (.287 wOBA, 87 wRC+) than at home (.330 wOBA, 125 wRC+). The Rays are also below-average vs. righties over the past 10 days with a .289 wOBA (25th in MLB) and 92 wRC+ (23rd). 

As Cease does his thing, bank on enough run support from the San Diego hitters against Ryan Pepiot. The Rays’ starter is off to a rough start this season with a 4.82 ERA and 5.71 FIP through five starts. He’s given up eight home runs over his past four starts and is allowing an 11.8% barrel rate (21st MLB percentile).

The right-handed Pepiot can easily run into trouble on the road here. The Padres are an elite offense at home with a .350 wOBA (5th), 130 wRC+ (3rd), .277 batting average (3rd), 16.5% K rate (2nd), and 11.6% walk rate (2nd). They’re also a top-10 offense against righties (.329 wOBA, 112 wRC+). 

Furthermore, the Padres have a slight bullpen advantage. San Diego relievers have a 3.16 FIP this season (4th in majors), while Tampa’s pen has a 4.50 FIP (24th). Back the home Padres to win outright and lead after five innings. 

 

 

 

Reds vs. Rockies Predictions: Saturday, April 26th

Hunter Greene is an early top contender for the NL Cy Young with his strong start to the season. The Cincinnati Reds’ ace has a 2.35 ERA, 0.78 WHIP, and 35:6 K:BB ratio through five starts. Let’s back Greene to anchor our MLB picks in today’s matchup against the Colorado Rockies. 

Greene just got rocked last time out with five runs allowed on six hits across just 3.0 innings at Baltimore. He’s due to bounce back and return to the pitcher who had a 0.98 ERA across his first four outings. Greene’s 29.7% K rate (83rd MLB percentile), 31.9% whiff rate (84th), 5.1% walk rate (84th), and .211 xBA (78th) are all still top-tier. 

The Reds’ right-hander will have to deal with Coors Field today, but the matchup is favorable besides the hitter-friendly environment. The Rockies are a bottom-level offense against righties this season with a .282 wOBA (27th in MLB), 64 wRC+ (30th), .212 batting average (29th), and 29.1% K rate (30th). 

Colorado’s offense is better at home this season, but the lineup is still very beatable for a pitcher of Greene’s caliber. Plus, the Rockies have been held to three runs or fewer in 5-of-9 home games thus far. 

Meanwhile, the Reds should plate some runs against Rockies starter Antonio Senzatela. The right-hander has a 4.81 ERA and 1.93 WHIP this year. His 6.80 xERA and 5.16 FIP don’t offer much confidence either. Senzatela will face a Reds offense that’s crushing righties over the past two weeks with a .372 wOBA (1st in MLB), 130 wRC+ (4th), and .294 batting average (1st). 

Cincy has enough offensive firepower to get to Senzatela, who’s given up 14 runs and 23 hits over his last 14.2 innings. Back the Reds to cover the runline and win by 2+ runs, in addition to leading after the first five innings.

 

 

 

Best MLB Player Prop Bets & Other Picks Today, 4/26