MLB Best Bets Today, 4/19: Picks, Predictions & Player Props - Saturday

Welcome back to another round of MLB Best Bets Today as the 2025 baseball season rolls on.
Saturday’s slate is filled with 15 games on the baseball schedule with every team in action. Before the games get going, let’s find some winning MLB predictions and picks. We’ll focus on two games for our MLB best bets today before dishing out a few baseball player props to consider.
Keep in mind, some of these odds or lines could move before first pitch. Also all bets below are for one unit. Without further ado, let’s dive into our MLB Best Bets Today.
MLB Picks, Predictions & Best Bets Today, 4/19
Our MLB Best Bets Today start with Chris Sale and the Atlanta Braves hosting the Minnesota Twins in an inter-league matchup. Can Sale bring some of his Cy Young-winning mojo into this game?
We’ll also dive into another inter-league battle between the San Diego Padres and Houston Astros for our second round of MLB predictions. Check out the MLB best bets and props to make as you enjoy Saturday’s baseball action.
Twins vs. Braves Predictions: Saturday, April 19th
It’s been a shaky start to the season for Chris Sale. The reigning NL Cy Young winner has a 6.63 ERA and 1.53 WHIP through his first four starts. Despite the uninspiring results, it’s also prime buy-low time for the Atlanta Braves’ ace in tonight’s home matchup against the Minnesota Twins.
Sale has some encouraging underlying metrics to trust moving forward. First, he’s been very unlucky with a .407 BABIP and 61.2% left-on-base rate. That’s resulted in a 3.63 FIP that’s three full runs lower than his ERA. Plus, he’s faced tough offenses in all four starts thus far (Padres, Dodgers, Phillies, Rays).
The southpaw has also been on the road for three of his four starts. He should have better outings at home, where he posted a 2.28 ERA last year. Sale’s control is currently there as well. He has a 24:4 K:BB ratio through 19 innings and a 96th percentile chase rate.
Better starts should be coming for Sale, who gets a very favorable matchup at home tonight. The Twins are the league’s worst offense against left-handed pitching this year with a .182 wOBA, .122 batting average, and 33.3% K rate that all rank dead last in the split.
On the other side, Sale should get enough run support from a Braves offense that’s also in buy-low territory. Twins starter Simeon Woods Richardson had a 4.30 ERA and 1.57 WHIP through three outings. He allowed four runs on eight hits and four walks in his last road start. Atlanta is hitting right-handed pitching well lately with a .347 wOBA (8th) and .266 batting average (4th) in the split over the past two weeks.
To complete the buy-low trifecta, we should be backing the Braves to get back on track after a terrible start to the season. Atlanta had to play 13 of its first 18 games on the road. Meanwhile, Minnesota is 3-8 on the road itself so far this year.
- Expert Twins vs. Braves Picks:
- Braves -1.5 Runline (+102 on DraftKings Sportsbook)
- Braves 1st 5 Innings -0.5 RL (-135 on DraftKings Sportsbook)
Padres vs. Astros Predictions: Saturday, April 19th
Following his breakout season last year, Michael King is off to a good start to the 2025 campaign. He has a 2.42 ERA and 1.07 WHIP through four outings. King’s 2.72 xERA and 3.22 FIP are encouraging as well. Let’s back the San Diego Padres right-hander to keep it going against the Astros today.
Houston’s offense has underwhelmed for most of the season. The Astros rank 24th in the MLB in runs scored and 27th in team OPS. Only one hitter is batting above .300 this year (Jose Altuve) while multiple guys are slumping. The ‘Stros have struggled against right-handed pitching with a .289 wOBA (25th) and .226 BA (23rd) in the split.
Even on the road, it’s a good spot for King to be effective. The righty just tossed a complete-game shutout against the Rockies last time out. He also has a 21:4 K:BB ratio over his last three starts. Last year, King boasted a 2.65 ERA on the road and a 2.41 ERA in night games.
Meanwhile, the Padres are one of the top offenses in baseball right now. It’s a tough matchup for Astros starter Hayden Wesneski, who has a 4.00 ERA and 4.94 FIP through three starts. He’s shown some flashes, including a 10-strikeout outing last weekend. However, San Diego presents a step up in competition from the lineups he’s faced thus far.
The Padres are crushing right-handed pitching. They boast a .350 wOBA (4th in MLB), .289 batting average (1st), and low 17.6% K rate (3rd) in the split so far this season. Some of that is due to a hot start, but San Diego is a top-10 offense vs. righties over the past week as well.
Furthermore, Houston hasn’t won consecutive games all season while alternating wins and losses for 14 straight contests. That trend tells us a down performance could be coming after the Astros beat the Padres last night. San Diego, on the other hand, has a league-best 15-5 record.
- Expert Padres vs. Astros Picks:
- Padres Moneyline (-125 on BetMGM)
- Padres 1st 5 Innings ML (-120 on BetMGM)
Best MLB Player Prop Bets & Other Picks Today, 4/19
- Casey Mize, Detroit Tigers – Over 3.5 Strikeouts (+112 on FanDuel Sportsbook)
- Taijuan Walker, Philadelphia Phillies – Over 4.5 Strikeouts (-116 on FanDuel Sportsbook)
- Kodai Senga, New York Mets – Under 5.5 Strikeouts (+112 on FanDuel Sportsbook)
Player News
Austin Gomber (shoulder) will come off the 60-day injured list to start Sunday against Atlanta.
Gomber will make his season debut after missing the first two-plus months of the season with his shoulder issue. The 31-year-old has been effective at times, but his inability to miss bats while playing for a team that has shown an inability to be competent makes him a hard pass in fantasy leagues.
Brewers transferred Brandon Woodruff from the 15-day injured list to the 60-day injured list.
Woodruff’s transfer to the 60-day list clears a spot on the 40-man roster, and the Brewers used it to select the contract of Jacob Misiorowski for his MLB debut Thursday. The 32-year-old was removed from his rehab assignment last week, and doesn’t have a timetable for a return.
Brewers optioned RHP Easton McGee to Triple-A Nashville.
Brewers selected the contract of RHP Jacob Misiorowski from Triple-A Nashville.
Rockies optioned LHP Carson Palmquist to Triple-A Albuquerque.
Palmquist forged a 7.77 ERA and 1.82 WHIP over his 22 innings as a member of the rotation. The 24-year-old will likely make starts for Colorado before the 2025 season comes to a close, but it’d be foolish to consider him in any sort of fantasy league you can imagine in your head.
Rockies recalled RHP Anthony Molina from Triple-A Albuquerque.
Molina, 23, is up for the second time this season after throwing a scoreless inning of relief in his previous stint. The right-hander will take the roster spot of Carson Palmquist, who was optioned to Triple-A after Thursday’s start.