PrizePicks NFL Picks For MNF, 9/30: Expert Picks, Projections & More

We have a doubleheader to close out Week 4 with Monday Night Football matchups between the Seattle Seahawks taking on the Detroit Lions and the Tennessee Titans facing off against the Miami Dolpins.
For our PrizePicks NFL picks MNF, we are looking at Detroit Lions running back Jahmyr Gibbs and Seattle Seahawks wide receiver DK Metcalf in an entry with a 3.75x multiplier.
PrizePicks NFL Picks for Monday Night Football Double Header, 9/30: NFL PrizePicks Projections
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DK Metcalf PrizePicks NFL Pick: More Than 79.5 Receiving Yards
We got a “demon” to kick off our Monday Night Football picks with Metcalf's receiving yard projection set at 79.5 yards. The Seahawks top wide receiver has gone over 100-yards in each of the last two weeks as part of one of the leagues top passing offenses.
The Lions are a defense that is really strong against the run but beatable through the air and that's what we are betting on here tonight with Metcalf making some big plays against this Detroit secondary.
- PrizePicks NFL Picks For MNF: More Than 79.5 Receiving Yards
Jahmyr Gibbs PrizePicks NFL Pick: More Than 80.5 Rushing Yards + Receiving Yards
The Lions running back has gone over this total with just rushing yards over the last two weeks, rushing for 83 and 84 yards agaisnt the Cardinals and Buccaneers. On top of that he has added over 20 receiving yards each week as well for 100+ total yards of offense.
We are going to be looking for more of the same from Gibbs who should be locked into double-digit carries and a handful of targets against a Seattle defense that has some injury concerns on their defensive front this evening.
- PrizePicks NFL Picks For MNF: More Than 80.5 Rushing Yards + Receiving Yards
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Player News
49ers signed No. 11 pick EDGE Mykel Williams to a four-year contract.
The deal is worth $24.9 million and is fully guaranteed. As is the case with all first-round picks, his contract includes a fifth-year option. The 49ers shed hundreds of millions of dollars in contracts this offseason and the bulk of those savings came on the defensive side of the ball. Defensive end was an obvious position of need and Williams was widely regarded as the best pass-rusher on the board when 49ers GM John Lynch was on the clock. Williams totaled five sacks in 2024 and left Georgia with 14 sacks across three seasons as a starter.
Vikings signed No. 24 pick OG Donovan Jackson to a four-year contract.
It’s a fully guaranteed deal worth $17.2 million with a fifth-year team option. Minnesota taking Jackson with the 24th-overall pick came as a bit of a surprise on draft night, but the Vikings needed offensive line help and Jackson was considered worthy of a first-round pick by some draftniks. He was primarily a left guard at Ohio State but successfully kicked out to tackle for the bulk of his senior season. Jackson is likely fated for guard duties in Minnesota, but the positional versatility remains a plus.
Titans claimed Anfernee Orji off waivers from the Saints.
Orji played primarily on special teams in New Orleans but was credited with two starts across 16 appearances. He totaled 30 combined tackles and a pair of TFLs. Orji will need to continue seeing work on special teams to make the Titans’ roster.
Patriots signed RB Trayveon Williams, formerly of the Bengals.
Henderson was passed on the Cincinnati depth chart by Chase Brown last year and the team even traded for Khalil Herbert midseason. Despite having no role on offense, Williams was active for all 17 games as a special teamer. He will likely hold a similar role in New England if he cracks the team’s 53-man roster.
Free agent RB Jordan Mims worked out for the Patriots.
The Pats also worked out former Bengals running back Trayveon Williams. Mims ran 20 times for 70 yards in 2024 while adding 12 catches for 71 yards through the air. He also got some run on special teams. The Patriots are looking for some extra depth at running back, but there isn’t room for another fantasy-relevant option behind Rhamondre Stevenson and TreVeyon Henderson.
Jaguars signed TE Quintin Morris, formerly of the Bills, to a one-year contract.
Morris is purely a blocking tight end. He caught just 15 passes during his three years with the Bills, though he did manage to find the end zone three times. Morris will back up Brenton Strange in Jacksonville.