If for some reason you’re searching for a Week 12 mismatch for this weekend, then look no further than Carolina with the Panthers hosting the Kansas City Chiefs. It’s a matchup between the two-time defending champs and last year’s worst record, and we’ve still found a value spot in the Chiefs vs. Panthers odds to provide you with a best bet from our Chiefs vs. Panthers predictions.

Even if you end up seeing other Chiefs vs. Panthers picks that you like along the way, we’ve also shared a monster $1,500 BetMGM Sportsbook welcome bonus for you!

 

 

 

Chiefs vs. Panthers Predictions For NFL Week 12, Sunday 11/24

If not for the Detroit Lions blowing teams away, this would likely be the biggest mismatch we see all season, and it will still be among the most significant. Even on the road and coming off their first loss of the season, the Chiefs are double-digit favorites over Carolina.

The Panthers are even coming off their bye week, but at the end of the day, Kansas City is simply the more talented team. Here is what we’re looking out for when it comes to Chiefs vs. Panthers predictions - the potential return of KC RB Isaiah Pacheco.

He’s able to do so, and even technically was this past Sunday. With Carolina having an abysmal run defense, we’re predicting that Chiefs head coach Andy Reid leans heavily into the ground game to simply get in and get out with a win.


 

 

Kansas City Chiefs: Cheers To The ‘72 Dolphins

As they do every year, the 1972 Miami Dolphins were able to pop their champagne and toast on social media with yet another season going by where there will not be an undefeated NFL team. While there was still a long way to go, the Chiefs were the last remaining hope for the long streak to end.

Of course, they’ll always say that their focus has been winning another Super Bowl, but doing so while remaining undefeated certainly would have made it even more special. Regardless, you can now argue that the stress of such a glorious season is now off their back and they can play a bit less uptight.


 

 

 

Carolina Panthers: Growing From Germany

We mentioned that the Panthers were coming into this matchup having just had their bye week, and that was thanks to having played overseas the week prior. Rather than the London matchups that we’ve gotten accustomed to, it was actually in Germany.

Despite blowing their lead to the New York Giants, they were able to hang on and grab the win in overtime. Taking down the lowly G-Men, who just benched the QB they paid this offseason, isn’t exactly Earth-shattering, but it did get them to surpass their entire win total of last year now that they’re 3-7.


 

 

 

Chiefs vs. Panthers Odds, Spreads, Total & Betting Lines

We weren’t exaggerating when we said that the defending champs were huge road favorites - here are the latest Chiefs vs. Panthers odds at BetMGM Sportsbook:

 

 

Chiefs vs. Panthers Best Bet: Kansas City First Half Team Total Over -6.5 Points (-112 at BetMGM Sportsbook)

Speaking of road favorites, it’s one of the most glaring trends of the 2024-25 NFL season. Teams in such situations are an incredible 44-19 against the spread, which is just a tick under 70%.

So, you could certainly consider that among your Chiefs vs. Panthers picks; however, KC is fantastic at winning games, but not blowing teams out by double digits. As for another pick from our Chiefs vs. Panthers predictions, we’d love to target KC RB Isaiah Pacheco’s prop markets, as Carolina has allowed the most rushing yards per game AND touchdowns.

While those aren’t available to us, those factors provide us with a spot to buck a trend. The Chiefs have become notorious for slow starts, but with this matchup, it’s time for them to put that to rest, at least for a week.

Not to mention, having just had their dreams of an undefeated season ruined en route to trying to become the first team in NFL history to pull off a three-peat, they should come out as fired up as ever. 

Even without that factor, Carolina has been nothing short of embarrassing this year in the first half of games. They are allowing the absolute most points per game in the first two quarters, and the gap between them and the next-closest team is more than a full field goal. Along with a fired up KC squad, the best bet from our Chiefs vs. Panthers predictions is the Kansas City first half team total over -6.5 points (-112 at BetMGM Sportsbook).

 

 

 

Chiefs vs. Panthers Injury Report & Latest News

Given the focus of our Chiefs vs. Panthers picks, we’d love to see Pacheco back on the field this Sunday, and he is absolutely the biggest injury news regarding this AFC vs. NFC matchup. You can keep track of all the latest news with Fantasy Alarm’s very own NFL injury report.


 

 

 

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