Chiefs vs. 49ers Predictions, Picks & Odds: NFL Week 7, Sunday 10/20

It’s finally here - the Super Bowl rematch we’ve all been waiting for! It was just last season that we saw the second-ever Super Bowl go to overtime with the Kansas City Chiefs taking down the San Francisco 49ers, and now we get to see them go at it once again. Therefore, we want to get you ready for the rematch with our Chiefs vs. 49ers predictions.
As if a Super Bowl rematch wasn’t exciting enough, we’ve got more than just Chiefs vs. 49ers picks for you - we also have a $300 FanDuel Sportsbook new user bonus that you can grab!
Chiefs vs. 49ers Predictions For NFL Week 7, Sunday 10/20
If the Chiefs aren’t in prime time, or their bye like they were last week, they always seem to find a way to be a part of the most polarizing game of the week. Of course, trying to become the first team in NFL history to win three straight Super Bowls certainly helps with that.
Regardless, we expect a back-and-forth game just like we saw in last year’s Super Bowl. So, seeing a tight point spread of just a point or two is far from surprising. While we’re going to provide the full analysis for the best bet from our Chiefs vs. 49ers predictions, we indeed have multiple angles that we like.
With the game in San Francisco, we see the ‘9ers grabbing the win, but as many fans know, betting against Kansas City is always a sweat. That’s why our best bet focuses on a different market, so let’s check out each team.
Kansas City Chiefs: Staying Strong Off A Bye
As if the Chiefs weren’t already scary enough to bet against, that is particularly true coming off a bye week. Specifically, that has been the case with head coach Andy Reid leading the squad. Even dating back to his days in Philly, he has been excellent getting his teams prepared with the extra week.
You know that is especially true knowing that they have this Super Bowl rematch on the horizon. Heading into this matchup, Reid is a remarkable 21-4 coming off a bye week. Let’s also not forget how scary QB Patrick Mahomes is as an underdog; he’s an incredible 11-1-1 against the spread in such games!
San Francisco 49ers: Grabbing The NFC West
There’s no denying that the 49ers have left plenty to be desired so far this season, and of course, injuries have certainly played a part in that. Even still, they haven’t looked like the NFC favorites they were labeled heading into the season.
Despite their up-and-down year to this point, their win over the Seattle Seahawks on Thursday Night Football puts them in prime position to take control of the NFC West this week. They’re just 3-3, so they’re being granted an opportunity that generally wouldn’t be there. Speaking of TNF, that also means that they’ll have just had a mini bye week as well.
Chiefs vs. 49ers Odds, Spreads, Total & Betting Lines
We mentioned a tight point spread already, and you can see the latest Chiefs vs. 49ers odds at FanDuel Sportsbook below:
- Point Spread: Kansas City Chiefs +1.5 (-105) vs. San Francisco 49ers -1.5 (-115)
- Money Line: Kansas City Chiefs (+100) vs. San Francisco 49ers (-122)
- Game Total (Over/Under): Over 47.5 (-110) vs. Under 47.5 (-110)
Chiefs vs. 49ers Point Spread: Under 47.5 Points (-110 at FanDuel Sportsbook)
Again, we wouldn’t be opposed to you adding San Francisco’s side, perhaps even just the money line, as part of your Chiefs vs. 49ers picks. However, we’re going to be focusing our Chiefs vs. 49ers predictions on the under.
It may not always be the most fun rooting against points, but it’s one of the biggest discrepancies we have this week in terms of our projections and the actual line. We have the total set at just 44 points, so we’re more than comfortable going under this total.
While Mahomes always takes the headlines for the Chiefs given his incredible talent, it’s been their defense led by Chris Jones that has been the stronger unit for KC, especially this season. We’ve already heard Mahomes openly state that the offense isn’t operating on all cylinders, which is why we’ve seen the defense be the reason for the wins recently.
In their past two games, the Chiefs have allowed just 13 and 10 points. As for the 49ers, they’ve been predicated on defense for a few years now, and they rely on it even more with key injuries on the offensive side, most recently RB Jordan Mason. They haven’t put up the numbers expected thus far, but LB Fred Warner knows how to lead this squad against a KC offense that is also missing key weapons like WR Rashee Rice.
We may still get to enjoy another incredibly exciting overtime game, but one that stays under 47.5 points (-110 at FanDuel Sportsbook), which is the best bet from our Chiefs vs. 49ers predictions.
Chiefs vs. 49ers Injury Report & Latest News
We’ve already noted a few injuries, which certainly play a part in handicapping the Chiefs vs. 49ers odds, and you can see the Thursday practice report below:
KC Chiefs:
- Mike Danna - DNP
- JuJu Smith-Schuster - LP
SF 49ers:
- Jauan Jennings - DNP
- Jake Moody - DNP
- Matthew Wright - DNP
- Kevin Givens - DNP
- Jordan Elliott - LP
- Maliek Collins - LP
- Darrell Luter Jr. - LP
- Jordan Mason - LP
- Malik Mustapha - LP
- Deebo Samuel - LP
How To Bet On Chiefs vs. 49ers at FanDuel Sportsbook & Claim Your $200+ Bonus
Don’t worry if you end up taking an angle other than our Chiefs vs. 49ers predictions - we’ve still got a ‘bet $5, get $300’ FanDuel sign up bonus for you:
- Sign up here for a new FD account
- Make an initial deposit of $10 or more
- Wager at least $5 on any sporting event
- Receive $300 in bonus bets if it wins
We completely understand if you want to place that qualifying bet on a game other than one expected to be so close like the Chiefs vs. 49ers matchup, as it just needs to win! Target a massive favorite or anything you’d like but get the ball rolling by using this link to join FanDuel.
Player News
Panthers released TE Jordan Matthews.
Matthews converted to tight end a few years ago and hasn’t made much noise at the position. The change has, however, likely kept him in the league for a few more seasons. He appeared in four games with the Panthers last year but didn’t record any stats on offense. The Panthers also released or waived WR Dax Milne, C Andrew Raym, and TE Colin Granger.
Dolphins released LS Blake Ferguson.
The team also waived CB Ryan Cooper Jr., DT Neil Farrell and OL Chasen Hines. Ferguson has been the team’s long snapper for five seasons and earned a three-year contract extension just before the 2023 season. He should be able to find work snapping footballs farther than the average snap elsewhere in the league.
DetroitLions.com’s Tim Twentyman believes rookie WR Isaac TeSlaa “could make his earliest impact on special teams.”
It’s not much of a surprise, as most rookies cut their teeth with special teams duties. Twentyman mentioned return duties as a possibility, though the former Razorback never returned kicks or punts in college. At 6'4/212 with 4.43 wheels, TeSlaa is an explosive athlete who never translated his physical traits to on-field production at Arkansas. The Lions clearly saw potential for him to do so in the pros and traded two future third-round picks to move up to No. 70 overall for him. It’s going to be a slow burn for TeSlaa in the pros, making him a dynasty-only fantasy option.
Vikings head coach Kevin O’Connell said the team does not “have any feelings on competition” when asked about the quarterback room.
O’Connell was asked about a potential quarterback competition on the Rich Eisen Show Wednesday and was unclear on whether J.J. McCarthy would have to compete to start. He said, “we’ve got an obligation as coaches to put our players in position to attack that competition phase.” O’Connell discussed first putting Brett Rypien and the newly acquired Sam Howell in a position to play before any competition would occur. He continued that McCarthy is “owning it” this offseason and is taking snaps from starting center Ryan Kelly. After missing last season with a torn meniscus, McCarthy has been ramping up workouts in the offseason and is the front-runner to start for the Vikings in 2025. As of now, Howell looks to be reinforcement at the backup spot in case it turns out McCarthy is not ready to start.
Texans re-signed DT Foley Fatukasi.
Fatukasi initially joined the Texans last offseason on a one-year contract. The 30-year-old was a rotational defensive lineman, tallying four tackles for loss and one sack. He returns to Houston for 2025, where he will be a part of a deep Texans front seven.
NFL Network’s Tom Pelissero reports Tyreek Hill’s second wrist surgery was part of the original plan and his timeline remains unchanged.
Hill announced the second surgery on social media and Pelissero quickly added some context to the situation. The speedy receiver suffered the wrist injury just before the start of the season and it lingered throughout the year, though he never missed a game because of it. If the second surgery truly is a non-story, an offseason to recover might be what Hill needs to return to form after a down 2024 season. On the other hand, Hill is 31 years old, played his worst football last year, and his offense prioritized targets for Jonnu Smith and De’Von Achane. As it stands, Hill might have the highest risk-reward split in fantasy drafts.