Browns vs. Eagles Predictions, Picks & Odds: NFL Week 6, Sunday 10/13

Talk about two teams trending in different directions. The Philadelphia Eagles, fresh off a bye week, will have A.J. Brown, DeVonta Smith, and Dallas Goedert all back from injury. Meanwhile, the Cleveland Browns have been riddled with injury and saddled by poor quarterback play from DeShaun Watson.
With all that in consideration, it’s no surprise that this one is expected to be fairly one-sided. But big spreads like that can make predictions like Sunday’s Browns vs. Eagles matchup more difficult to make than ever. Let’s dig into the info we have and see if there is a best bet to be made!
Even if you just want to see the Browns vs. Eagles odds and have Browns vs. Eagles picks of your own, don’t forget to scroll down at the end to see how you can scoop up a $1,500 BetMGM Sportsbook sign-up bonus!
Browns vs. Eagles Predictions For NFL Week 6, Sunday 10/6
Since the Browns are AFC and the Eagles are NFC, these teams only play every four years unless they meet in the Super Bowl. And the Browns have literally never appeared in a Super Bowl, so we know the last time they squared up was 2020.
The Browns managed to beat the Jaguars in Week 2 but have lost to the Cowboys, Giants, Raiders, and Commanders. The Eagles beat the Packers and Saints while losing to the Falcons and Buccaneers right before the bye. They’ll meet this week in Philadelphia on Sunday at 1 PM ET.
Cleveland Browns: Time To Give Up On Deshaun Watson?
Here’s how good Deshaun Watson was for the Houston Texans - despite his atrocious play with the Browns, he is still a top five quarterback of all time in fantasy points per game. Unfortunately, whether it’s due to the shoulder injury or some sort of mental block, the Cleveland version of Watson has been a complete failure. And it might be time for a change.
There’s really no easy way to get out of the contract. But, at a certain point, the Browns may need to start thinking about their future. If Deshaun Watson can’t put together reasonable drives, you need to get Jameis Winston in there.
You are not only trying to figure out if Winston is the guy for the future, but you’ll also have another variable to figure out if Deshaun Watson truly is the problem or if the entire team is simply that bad. The thing about bad offense is that you don’t give your defense time to rest.
So, it’s hard for them to be great under those conditions. Throw in the myriad injuries the Browns have suffered so far this year and they’ve really just been middle of the pack so far, despite being a great unit on paper.
Philadelphia Eagles: Bye Week To The Rescue
The Philadelphia Eagles were already down AJ Brown and DeVonta Smith going into Week 4. Then Dallas Goedert got nicked up towards the end of that game. Usually, teams don’t want the earliest bye week of any team, but the Week 5 bye came at the perfect time for the Eagles.
The only limited participant the Eagles had in practice Thursday was Nakobe Dean, and, on Friday, everyone was a full participant. So, the Browns will face the like of Jalen Hurts, AJ Brown, DeVonta Smith, Dallas Goedert, and Saquon Barkley with no injury designation coming off a fresh week of rest.
The Eagles defense has not been spectacular thus far. In fact, they are ranked 27th in DVOA per FTN Football. This has generally led to shootout conditions for the Eagles, but the Browns would need to keep up their end of the bargain for that.
Browns vs. Eagles Odds, Spreads, Total & Betting Lines
As promised, the latest Browns vs. Eagles odds can be found below courtesy of BetMGM Sportsbook:
- Point Spread: Cleveland Browns +9.5 (-110) vs. Philadelphia Eagles -9.5 (-110)
- Money Line: Cleveland Browns (+375) vs. Philadelphia Eagles (-500)
- Game Total (Over/Under): Over 43 (-105) vs. Under 43 (-115)
Browns vs. Eagles Predictions: Over 43 (-105 at BetMGM Sportsbook)
Call me crazy, but I think the Browns force the Eagles to play here. Whether it’s Deshaun Watson or Jameis Winston with a halftime adjustment, I think the Browns quietly have the pieces with Amari Cooper, David Njoku, Jerry Jeudy, and Jerome Ford to actually move the ball on this struggling Eagles defense.
This line, with a 9.5 point spread and a 42.5 O/U, leaves the Browns with one of the lowest implied point totals on the slate at 16.5 points. I have no doubt that the Eagles can put up points on this Browns defense and I would not be shocked to see them win by double digit points and cover.
But I also believe the Browns can actually hold up their end of the bargain here and put up some points on the Eagles. So, I’m going with the over in this one.
Browns vs. Eagles Injury Report & Latest News
Finally, let’s take a quick look at the projected starting lineups for both teams heading into tonight’s matchup:
CLE Browns:
- RB Nick Chubb - Out
- S Grant Delpit - Out
- S Ronnie Hickman Jr - Out
- RB Nyheim Hines - Out
- OT James Hudson - Out
- C Ethan Pocic - Out
- LB Mohamoud Diabate - Questionable
- LB Jordan Hicks - Questionable
- DT Maurice Hurst - Questionable
- CB Denzel Ward - Questionable
PHI Eagles:
- None
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Player News
Dolphins signed No. 13 overall pick DT Kenneth Grant to a four-year contract.
ESPN’s Jeremy Fowler reports that Grant will sign his contract today. The former Michigan defensive tackle is expected to fill a major void left by Christian Wilkins, who left for the Raiders in the 2024 offseason. Grant totaled 32 tackles, three sacks, and seven TFLs in his final season at Michigan and excelled at stopping the run while also generating 27 pressures in his final season, per PFF.
Beat reporter John Hendrix reports that free agent WR Donovan Peoples-Jones is among the 16 players that the Saints will host for their rookie minicamp.
Peoples-Jones last played regular season snaps with the Lions back in 2023, when he caught 13-of-24 targets for 155 yards. He is highly unlikely to return to fantasy relevance at this point but could perhaps sign on as a special teams contributor.
Titans signed fourth-round pick WR Elic Ayomanor to a four-year contract.
Ayomanor will now begin learning behind Calvin Ridley. Although Ayomanor is unlikely to find a meaningful role in year one, dynasty managers should note his status as training camp gets underway this summer. The former Stanford receiver flashed big-play ability in his two college seasons.
Buccaneers signed seventh-round pick WR Tez Johnson to a four-year contract.
Johnson will serve as a rotational deep-threat option for Baker Mayfield. His thin frame (5'10/154) simply does not lend itself to the repeated hits one incurs in a full-time role. Johnson did earn 100-plus targets in his two seasons at Oregon, though. His big-play style make him a better fit in best ball for now, pending any major on-field breakthroughs.
Giants waived DT Casey Rogers.
Rogers was a 2024 undrafted free agent and logged 33 defensive snaps for the Giants in his rookie season. He is credited with zero tackles and/or sacks. He may find his way onto another roster as a practice squad option.
Vikings signed third-round pick WR Tai Felton to a four-year contract.
Felton is quietly in play to challenge Vikings No. 3 WR Jalen Nailor in training camp. Nailor (5'11/190) caught 28-of-42 targets for 414 yards and six touchdowns in his first season as a starter last year, with the latter category buoying his fantasy productivity. Felton (6'1/183), meanwhile, caught 96-of-143 targets for 1,119 yards and nine touchdowns while averaging 2.32 yards per route run in his final college season. Fantasy managers should monitor Felton’s training camp reports this summer, as he could have a matchup-based WR5 role if everything falls into place.