Bills vs. Seahawks Predictions, Picks & Odds: NFL Week 8, Sunday 10/27

One of the most interesting matchups of the NFL Week 8 slate is one that features teams on complete opposite sides of the country with the Buffalo Bills taking the long flight to the Pacific Northwest to take on the Seattle Seahawks. These are two division leaders, and we want you to enjoy the matchups with the best bet from our Bills vs. Seahawks predictions.
Whether you end up tailing our Bills vs. Seahawks picks or approach the Bills vs. Seahawks odds differently, we also have the latest DraftKings Sportsbook welcome promo for you that provides a guaranteed $200 boost!
Bills vs. Seahawks Predictions For NFL Week 8, Sunday 10/27
Seeing that the Seahawks are a division leader may come as a surprise given that not only the San Francisco 49ers were favorites to win the NFC West, but the entire NFC! However, injuries have derailed their season, leading them to a losing record,
That means that Seattle is the only team in the entire division with a winning record of 4-3. Meanwhile, not only is the Bills 5-2 record the only winning one in the AFC East, but the next-best record is just 2-4! So, while both these teams may be division leaders, it’s difficult to call their situations equal.
The same can be said for the overall caliber of these squads; therefore, we aren’t surprised that Buffalo is listed as a road favorite. We’ll be focusing on that as part of our Bills vs. Seahawks picks, but we’ll take you through our full, somewhat unique approach coming up!
Buffalo Bills: Looking The Part
Before we get that far, why are we not surprised to see the Bills as road favorites? Some fans seem to forget that they were absolute world-beaters the first few weeks of the season thanks to the Baltimore Ravens beating them down in prime time.
However, they have since bounced back, evidenced by their 5-2 record, including a dominant 34-10 win in their most recent matchup. That said, they do still need to prove themselves true contenders, as they also narrowly pulled off back-to-back 23-20 wins prior to that. So, pulling off a win while across the country would be a big step in the right direction.
Seattle Seahawks: Who Are They Really?
Interestingly enough, the Ravens play a part in Seattle’s storyline, but from last year! Stick with us here - prior to their game against Baltimore, the Seahawks had a top-six run defense. Then, after allowing 294 rushing yards in a 37-3 loss to the Ravens, they went on to finish the season as the second-WORST run defense.
That’s exactly what they want to avoid this year after starting 3-0 and having gone 1-3 since then. That includes a bad 29-20 loss to the 2-5 New York Giants, who also same across the country to Seattle. Buffalo is a much tougher task, so an upset here could really uproot the NFC West.
Bills vs. Seahawks Odds, Spreads, Total & Betting Lines
With the way that we’re approaching our Bills vs. Seahawks picks, we used the latest Bills vs. Seahawks odds at DraftKings Sportsbook, which you can see below:
- Point Spread: Buffalo Bills -3 (-110) vs. Seattle Seahawks +3 (-110)
- Money Line: Buffalo Bills (-162) vs. Seattle Seahawks (+136)
- Game Total (Over/Under): Over 46.5 (-110) vs. Under 46.5 (-110)
Bills vs. Seahawks Teaser: Buffalo +3 / Over 40.5 Points (-120 at DraftKings Sportsbook)
As you can see, our Bills vs. Seahawks predictions are focused on a teaser. This is a way of targeting multiple markets that you like while getting better lines for both of them. So, while both picks have to hit like a parlay, we’re getting much more favorable values.
Our Bills vs. Seahawks predictions are for a six-point teaser, so rather than Bills favored by three, they can even lose by three or less. Similarly, rather than needing there to be more than 46.5 points scored, we only need 41 or more points on the board.
Frankly, we like both lines as is, so we especially enjoy this approach. Perhaps the aspect that needs the least amount of convincing is a high-scoring game. After all, we've seen Buffalo eclipse this total themselves this season. Similarly, along with their 47-point performance, they’ve scored 31+ in four of their seven games this season.
After seeing Seattle allow 29 points to the Giants, we’re confident that the Bills can do that and then some. We also simply believe that Buffalo is the better team, so now getting them as underdogs is as valuable as it gets. So, if we somehow see a last-second field goal steal the win for Seattle, we’re still safe.
This has all been without mentioning that Buffalo also added a new weapon prior to last Sunday’s game - WR Amari Cooper. The former Cleveland Brown fit right in, catching a touchdown alongside his 66 receiving yards.
All being said, we love focusing our Bills vs. Seahawks predictions on a teaser of Buffalo +3 & over 40.5 points (-120 at DraftKings Sportsbook).
Bills vs. Seahawks Injury Report & Latest News
Both teams have dealt with injury concerns to key players throughout the first half of the season, and you can see the Thursday practice report for each side here:
BUF Bills:
- Terrel Bernard - DNP
- Curtis Samuel - DNP
- DeWayne Carter - LP
- Mack Hollins - LP
- Taron Johnson - LP
- Dalton Kincaid - LP
- Dawson Knox - LP
- Dawuane Smoot - LP
SEA Seahawks:
- WR DK Metcalf - DNP
- CB Tre Brown - DNP
- NT Cameron Young - DNP
- DE Mike Morris - DNP
- CB Nehemiah Pritchett - LP
- RB Kenneth Walker - LP
- T George Fant - LP
- T Abraham Lucas - LP
- CB Riq Woolen - LP
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Player News
Colorado CB/WR Travis Hunter said NFL teams he’s met with during the pre-draft process have no issue with him playing both sides of the ball.
Hunter said he would refuse to play for a team that did not allow him to play both corner and wideout. “Because I’ve been doing it my whole life, and I love being on the football field,” he told CBS Sports. “I feel like I could dominate on each side of the ball, so I really enjoy doing it.” Hunter in 2024 played 713 offensive snaps and 748 defensive snaps, “which made him the only player since at least 2017 with at least 250 snaps played on both offense and defense in a single season,” according to CBS Sports Research. Colorado head coach Deion Sanders, a mentor to Hunter, said Hunter could easily play both sides of the ball as a pro since physical contact in the NFL is “minimal.” Pro Football Focus graded Hunter as last season’s second best cover corner. The most likely outcome for Hunter, 21, would include a full-time defensive role in the NFL with a package of receiver snaps in certain situations. He’s expected to go in the first ten picks of the 2025 draft.
The Athletic’s Dianna Russini reports Louisville QB Tyler Shough could be taken in the first round of the 2025 NFL Draft.
Russini said Shough’s draft prospects have spiked over the past two weeks, going from a second or third round selection to a possible first rounder. That, of course, depends on how desperate quarterback-needy teams will be on the first night of the NFL Draft. An anonymous head coach told Russini that Shough, who threw for nearly 3,200 yards, 23 touchdowns, and six interceptions in his final collegiate season, is the best QB prospect in the entire 2025 draft class. Shough, who will be 26 in September, played seven years of college football, including stints at Texas Tech and Oregon. Pro Football Focus graded Shough as 2024’s fifth best passer. His adjusted completion rate in 2024 ranked 25th out of 93 qualifying QBs. It would be surprising if a team aggressively pursued a questionable, older QB prospect as a first-round selection.
ESPN’s Adam Schefter reports Shedeur Sanders on Thursday will hold “one last private workout” for representatives from the Giants.
It appears the Giants are very much considering using their first rounder on Sanders, whose draft prospects are all over the place in the run-up to the 2025 NFL Draft. “When this happens so late in the process either there’s a big disagreement in their building on their evaluation or their reacting to new information,” said former Jets GM and current ESPN analyst Mike Tannenbaum. Sanders could go in the top five picks or drop out of the first round depending on how the Giants, Browns, and other QB-needy teams approach the first night of the draft. It remains to be seen if Sanders, who threw 64 touchdowns in two seasons on his father’s Colorado team, would compete with Jameis Winston and Russell Wilson for New York’s Week 1 starting job.
NFL Network’s Ian Rapoport reports the Dolphins and CB Jalen Ramsey are exploring trade options.
Rapoport added that “it wouldn’t be a surprise if [Ramsey] played elsewhere in 2025.” The Dolphins owe Ramsey $25.1 million in 2025, and don’t seem eager to keep him onboard after an underwhelming two seasons in Miami. Ramsey has five interceptions for the Dolphins over 27 games, missing significant time with various injuries, including a lingering knee issue. Ramsey in 2024 was graded by Pro Football Focus as the league’s 24th best cover corner out of 133 qualifying cornerbacks. Entering his age-31 seasons, Ramsey should get a decent amount of interest in the trade market in the coming weeks.
ESPN’s Ryan McFadden reports Jakobi Meyers is “open” to an extension with the Raiders.
Meyers is entering the final year of a three-year, $33 million contract signed in the 2023 offseason and coming off an 87/1027/4 receiving line in 2024. McFadden writes that the team views Meyers as a “key player” on the roster. Meyers could probably come close to a $20 million AAV in a new contract given the way the market is trending — that’s about what Stefon Diggs got from the Patriots this offseason after a lengthy wait.
The Athletic’s Nate Taylor writes that the Chiefs “need a young, dynamic running back to pair with” Isiah Pacheco.
Rarely do you see a beat writer go with the word “need,” but here we are. Kansas City clearly had no juice in the running game all last season as Pacheco struggled to run the same after returning from a broken leg. Kareem Hunt was a steady veteran pounder but couldn’t hit a second gear. Taylor notes that Brett Veach has been quoted as saying running backs in Andy Reid’s offense “need to be a better receiver than a runner” and ties them to Georgia back Trevor Etienne.