The very first pitch of the stateside 2025 MLB Opening Day is scheduled to be in the Bronx with the New York Yankees hosting the Milwaukee Brewers. So, it’s only fitting that it will be featured on ESPN, and with it being an earlier 3:05 PM ET start time, we’re here to provide you with our Brewers vs. Yankees predictions.

We’ll also be providing you with a best bet from our Brewers vs. Yankees picks, and on top of all that, a huge $1,500 BetMGM Sportsbook sign up bonus!

 

 

 

Brewers vs. Yankees Predictions For MLB on ESPN, 3/27

Right from the very first pitch of the 2025 MLB season, we’ve got storylines everywhere. That’s even with this being an interleague matchup that doesn’t happen all too often, and it’s largely because this will already be a revenge game.

Although it won’t be seen until the tail end of the game if necessary, the Yankees nabbed arguably the best closer in all of baseball - Devin Williams - from the Brewers this offseason. That sent Nestor Cortes to Milwaukee as part of the deal, and to accommodate that loss, the Yankees also added lefty starter Max Fried to the rotation.

Having said all that, we won’t be seeing Cortes nor Fried on the mound today, but rather a matchup between Milwaukee’s Freddy Peralta and New York’s Carlos Rodon. Of course, starting pitching matchups are significant for any Brewers vs. Yankees predictions.

 

 

 

Milwaukee Brewers: Coming In Quiet

Before we fully dive into how that matchup will affect the best bet from our Brewers vs. Yankees picks, how else did Milwaukee spend their offseason other than sending away Devin Williams? It’s safe to say that they didn’t have the same type of blockbuster moves as others, but they were still active.

To continue the pitcher front, they too snagged a lefty in Jose Quintana, who has done his fair share of moving around in recent seasons. On the opposite end of his pitches, the Brew Crew also acquired catcher William Contreras. Outside of that, the team will look largely similar to the 2024 season. 

 

 

 

New York Yankees: So Long Soto

As for the Yankees, they had several offseason storylines, as you’d expect with such a high-profile (and high-salary) team. Speaking of which, it was a massive high salary that pulled Juan Soto away from the Bronx and over to Queens.

The New York Mets snatched the slugger from their cross-town rival to the tune of a whopping 4765 million contract! Of course, the Bronx Bombers weren’t without their own acquisitions, headlined by the aforementioned Max Fried. The lefty will certainly be relied upon right out of the gates given the Gerrit Cole injury.

 

 

 

How To Watch MLB Opening Week Today

While our focus here are Brewers vs. Yankees predictions, we also know that with the fresh new season underway, fans won’t want to miss a single bit of the action. So, how can you watch MLB Opening Day?

In general, just about all games will be on their regional sports network (RSN) with both Brewers vs. Yankees and Tigers vs. Dodgers being featured on ESPN. As for more in terms of this matchup…

  • Where: Yankee Stadium in Bronx, New York
  • When: 3:05 PM ET on 3/27
  • Watch on TV: ESPN
  • Where to stream: ESPN+

 

 

 

Brewers vs. Yankees Odds, Spreads, Total & Betting Lines

As you’d expect with New York being the favorite to win the entire American League and starting the season at home, the Brewers vs. Yankees odds at BetMGM Sportsbook have them as the clear favorite this afternoon:

 

 

 

Brewers vs. Yankees Best Bet: Over 8 Runs (-105 at BetMGM Sportsbook)

Finally, now that we’ve got plenty of info for this MLB Opening Day game under our belts, where are we headed for the best bet from our Brewers vs. Yankees predictions? We see the Brewers vs. Yankees odds priced towards the under for today’s game, and we’d love to see it tick down to 7.5 runs.

We generally see low totals when we know that both teams will be at the start of their rotation, which is why we’ll see relatively low totals for just about every game these first two days of the season. However, it’s just that - the start of the season.

In other words, starting pitchers are not only not going to be in midseason form, but they’ll also more than likely be on shorter leashes to be overly cautious for injury prevention. Therefore, an innings or outs prop could also be in play, but we want to keep things nice and basic for this first day of the season.

That’s all without even mentioning that we’re dealing with the Bronx Bombers at home. The Yankees may no longer have Juan Soto, but they didn’t need him before last season either with the likes of Aaron Judge and company. Yankee Stadium has also been great for over bettors, as it ranks sixth in terms of ball parks that are best for home runs.

Along with all that, New York and Milwaukee ranked fourth and eighth respectively for overs last season, so we’ll start this season by making the best bet from our Brewers vs. Yankees predictions on the over 8 runs (-105 at BetMGM Sportsbook).

 

 

 

Brewers vs. Yankees Injury Report & Starting Pitchers

With injury reports still being in offseason and spring training mode, they are littered with players, but that includes plenty that won’t be seen on actual rosters anyway. With that said, rather than sending you scrolling for days, let’s point out the most notable.

The Brewers’ latest news is regarding starting pitcher Brandon Woodruff, but he’s since been able to throw a few innings. As for Yankees news, it was also the biggest MLB news for quite some time - the aforementioned Gerrit Cole news. Along with his Tommy John surgery, New York also has injury concerns for Giancarlo Stanton, Luis Gil and Clarke Schmidt.

As for today’s Brewers vs. Yankees starting pitchers…

 

 

 

How To Bet On Brewers vs. Yankees at BetMGM Sportsbook & Claim Your $1,500 Bonus With Code ALARM

Of course, we couldn’t forget about a huge $1,500 BetMGM sign up bonus to go along with our Brewers vs. Yankees predictions. Here’s how you can claim yours ahead of first pitch:

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