Rams vs. 49ers Predictions, Picks & Odds: Thursday Night Football, 12/12
The theme of Thursday Night Football this season has been division rivalries, and that’s exactly what we have to kick off Week 15 with the San Francisco 49ers hosting the Los Angeles Rams. These are two teams that have been to Super Bowls rather recently, and we’ve got our Rams vs. 49ers predictions for you below.
Of course, that also means a best bet from our Rams vs. 49ers picks, which we’ll pair with a generous, multi-part FanDuel Sportsbook sign up bonus!
Rams vs. 49ers Predictions For Thursday Night Football, NFL Week 15
Per usual, the Rams and 49ers were in the late window of Sunday’s slate this past weekend, and they were each a part of two of the most polarizing games of the Week 14 action. However, they came in completely opposite fashions.
While LA was in an absolutely epic back-and-forth shootout with the Buffalo Bills that was one of the most fun games of the entire season to watch, San Francisco was a part of an absolutely massive blowout, crushing the Chicago Bears. So, we aren’t too surprised to see the Rams vs. 49ers odds having this matchup projected to be a close matchup.
LA was able to pull off the upset when these teams met back in Week 3, so can they do it again on the road? That’s what the best bet from our Rams vs. 49ers predictions is here to help answer after working through each team!
Los Angeles Rams: Rolling On With Momentum
Along with LA upsetting the 49ers in Week 3, they also just upset arguably the hottest and best teams in the NFL - the Bills. With how wide open the NFC West is right now - just two of the four teams have winning records - those two upsets could prove to be the deciding factor in either a division title or playoff berth in general.
While upsetting the 49ers right now doesn’t seem completely crazy, keep in mind, when they did so at the beginning of the season, San Francisco was still projected to win the entire NFC. LA should have confidence that they can do so again with their most recent win, and while they’ll be on the road this time, it’s just a short trip up the 405.
San Francisco 49ers: Building Positivity
Like the Rams, the 49ers also need to build off their recent win this past weekend but it’s from a different perspective. Rather than exceeding expectations like LA, San Francisco is performing well below them. Speaking of being below, they are at the very bottom of the NFC West!
Although it’s due to tiebreaker, seeing the expected NFC representative for the Super Bowl with a losing record is not what fans expected this season. While much of it has been due to very significant injuries, they were already not looking the part prior to those concerns. There’s still time to turn things around, and once the playoffs start, it’s an entirely new season.
Rams vs. 49ers Odds, Spreads, Total & Betting Lines
We noted that the Rams vs. 49ers odds have this NFC West rivalry projected to be a close one, and you can see the latest lines at FanDuel Sportsbook here:
- Point Spread: Los Angeles Rams +2.5 (-105) vs. San Francisco 49ers -2.5 (-115)
- Money Line: Los Angeles Rams (+122) vs. San Francisco 49ers (-144)
- Game Total (Over/Under): Over 48.5 (-114) vs. Under 48.5 (-106)
Rams vs. 49ers Best Bet: Over 48.5 Points (-114 at FanDuel Sportsbook)
With such a storied matchup, there is plenty of recent history to pull from for Thursday Night Football this week, which also means trends to find. Before we dive into the focus of our Rams vs. 49ers predictions, it’s worth sharing some interesting ones.
Over the past 10 meetings between these teams, the Rams are just 3-7 against the spread. However, all three of those covers have been in each of the three most recent matchups, and with how much these teams have changed the past couple of seasons, perhaps the trend to consider for your Rams vs. 49ers picks.
Regardless, we’re going to focus on another one. That would be the fact that each of the last four times these NFC West rivals have met, they have gone over the total. Prior to this season, prime time unders had been a great trend to back, but that has since changed as offenses continue to get more and more explosive.
Look back at just last Thursday Night Football where we had 65 total points scored. Admittedly, the totals in the last four meetings have been lower than this week’s, but even in their Week 3 matchup, there were 51 total points scored.
That’s without even mentioning how both of these teams lit up the scoreboard just a few days prior to this Thursday Night Football clash. The 49ers put up 38 points, and if it wasn’t a blowout early, they could have kept pouring it on. Similarly, the Rams put up 44 points on one of the best teams in the NFL this past Sunday.
Along with the fact that LA also allowed 42 points in that game, we should have no problem with over 48.5 points (-116 at FanDuel Sportsbook) as the best bet from our Rams vs. 49ers predictions.
Rams vs. 49ers Injury Report & Latest News
With the 49ers involved in Thursday Night Football, injuries are arguably the most significant piece of news. From losing RB Christian McCaffrey for the year, not to mention WR Brandon Aiyuk, there are also things to monitor for TNF specifically. We saw QB Brock Purdy exit last Sunday’s game, and for all injury updates, keep track of the Fantasy Alarm NFL injury report.
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Player News
Packers signed WR Bo Melton, RB Emanuel Wilson, and P Daniel Whelan to their exclusive rights free agent tenders.
Melton caught on with the Packers in 2023, totaling 16 receptions for 218 yards and a touchdown in five games. He added eight receptions for 91 yards in 17 games last season. Melton will continue to be a depth piece in an already-deep Packers wide receiver room. Wilson has also been with the Packers for two seasons and rushed for 502 yards and four touchdowns as Josh Jacobs’ immediate backup last season. He will compete with MarShawn Lloyd for that role again. Whelan is the team’s punter and will be back for 2025. All three signed their exclusive rights free agent tender and will essentially be on one-year contracts this season.
Seahawks re-signed Johnathan Hankins to a one-year contract.
Hankins hasn’t had a PFF run defense grade above 52.4 since 2020 and is primarily called on to play early downs. He turned 33 in March. He’ll be a complimentary piece behind Jarran Reed and Byron Murphy II if he makes the roster out of training camp.
Chargers placed the UFA tender on RB J.K. Dobbins.
This gives the Chargers exclusive negotiating rights if he does not sign with a team by July 22 or the first 2025 NFL training camp opens, whichever comes first. The tag is mainly useful for compensatory pick reasons as Dobbins will still count towards Los Angeles’ haul in the formula if signed before then. The Chargers currently do not project to add a pick in 2026 per Over The Cap’s Nick Korte.
49ers signed OT D.J. Humphries.
Humphries played in only two games for the Chiefs last year as he spent most of the season rehabbing a late 2023 torn ACL on his own. He wasn’t appreciably good in either of those games, but he was rusty and does have a history of better than that. Entering his age-32 season for the 49ers, he’ll probably be trying to win the right tackle job opposite Trent Williams in training camp.
Patriots released LS Joe Cardona.
The team selected his replacement, Julian Ashby, in the seventh round of the draft. This snapper of balls who are longer than usual is only 33, and it’s possible he picks up his career elsewhere. There aren’t too many remaining Patriots Regimes in the wild in 2025, but Nick Caserio does still run the Texans and they let Jon Weeks walk this offseason so that’s one speculative fit.
NewOrleans.Football’s Nick Underhill said he would be “flabbergasted” if Derek Carr played for the Saints this year.
“I would have trouble understanding why you would allow that to happen, you’re trying to build a new culture, you can’t let that guy ... you just got a rookie QB, this is the example you’re going to give him,” Underhill continued. Both Underhill and Mike Triplett believe Tyler Shough will be starting for the Saints in Week 1, with Underhill saying he had “80 percent or higher odds to start 80 percent of the games this year.” Shough would be an uninspiring superflex pick, perhaps a QB3, but given how things have played out with Carr over the past months it sure doesn’t seem like the Saints have a reason to want to continue this relationship. Mickey Loomis literally asked reporters to stop asking him Carr questions at his pre-draft press conference.