Eagles vs. Buccaneers Predictions, Picks & Odds: NFL Week 4, Sunday 9/29

Week 4 of the NFL season may have caught your eye with quite a few divisional rivalry matchups, but we’ve also got a playoff matchup from just last season! It was a Wild Card Round clash that saw the Tampa Bay Buccaneers eliminate the Philadelphia Eagles. Will Philly get their revenge, or will the Bucs send them packing again?
Our Eagles vs. Buccaneers predictions are here to help answer that, and a guaranteed $200 FanDuel Sportsbook sign up bonus will also be shared with you to add even more value to any Eagles vs. Buccaneers picks!
Eagles vs. Buccaneers Predictions for NFL Week 4, Sunday 9/29
When we say that the Bucs eliminated the Eagles in the opening round of the postseason last year, that doesn’t tell the full story. It was the nail in the coffin of what was one of the biggest collapses of the second half of a season, as Philly went from 10-1 to 11-6 to ultimately, get blown out 32-9 by Tampa in that Wild Card matchup.
This is all worth noting for any Eagles vs. Buccaneers predictions, as the clash was quite recent, and with so many of the same players involved, it will absolutely be what they are all thinking about. To foreshadow just a bit, we expect the phrase, ‘revenge is a dish best served cold’ to be fresh on the minds of Philly players.
Philadelphia Eagles: Soaking In The Saints Win
What many considered to be the game of the week last Sunday was the Eagles down in the Bayou taking on a New Orleans Saints team that had been absolutely dominant. It ended up being an extremely hard-fought, low-scoring game; just three total points were scored entering the fourth quarter!
Despite not scoring until that final frame, Philly still proved doubters and oddsmakers wrong, getting the win as three-point road underdogs. Now, they’re right around three-point road favorites. Truthfully, we wouldn’t mind taking Philly-2.5 from the Eagles vs. Buccaneers odds, but we’ve got a slightly different approach for the best bet from our Eagles vs. Buccaneers predictions.
Tampa Bay Buccaneers: Bouncing Back From The Broncos
Before we dive into that top pick, the Bucs had quite a different week last Sunday. Fans and analysts alike were enamored with Tampa’s 2-0 start to the year, and frankly, it was quite impressive. However, they were brought back down to Earth in a big way in Week 3.
Although they were at home inside Raymond James Stadium, they were blown out 26-7 by the then 0-2 Denver Broncos. Now that both teams are sitting at 2-1, it has made this matchup one of the most intriguing on the Week 4 slate, even beyond the fact that it’s a postseason rematch from last year.
Eagles vs. Buccaneers Odds, Spreads, Total & Betting Lines
Let’s quickly take a look at the latest Eagles vs. Buccaneers odds at FanDuel Sportsbook as we transition into the best bet from our Eagles vs. Buccaneers predictions:
- Point Spread: Philadelphia Eagles -2.5 (-115) vs. Tampa Bay Buccaneers +2.5 (-105)
- Money Line: Philadelphia Eagles (-135) vs. Tampa Bay Buccaneers (+114)
- Game Total (Over/Under): Over 45 (-115) vs. Under 45 (-105)
Eagles vs. Buccaneers Predictions: Philly Team Total Over 22.5 (-130 at FanDuel Sportsbook)
Above, you’ll see the Eagles vs. Buccaneers odds for the standard markets, and as mentioned previously, backing Philly at less than a field goal is certainly an approach we’d support. However, the focus of our Eagles vs. Buccaneers picks is on their team total.
That may come as a surprise given the low-scoring contest they were just in with the Saints, but the Bucs are a different NFC South team that doesn’t have quite that caliber of defense. Even still, last week’s matchup has oddsmakers providing us with a more favorable value, so we’ll gladly take it.
We just saw Tampa allowed 26 points to the Broncos. While that certainly isn’t a record-setting number, it’s easily enough for us to hit our Eagles vs. Buccaneers predictions, and Philly’s offense can absolutely outscore Denver’s.
It isn’t just that the Bucs allowed 26 points last week, but it was the fact that it came to a rookie QB in Bo Nix that struggled through the first two weeks of the season. That’s putting lightly for their game just prior to the one against Tampa as well, as the Broncos scored just six total points in Week 2 on their home turf.
We’re also getting a more favorable number with the WR injuries on Philly’s side, so we certainly aren’t ignoring that factor. However, RB Saquon Barkley has proven to be an entire offense himself since scoring three touchdowns alone in his team debut. With all that in mind, the best bet from our Eagles vs. Buccaneers predictions is Philly’s team total over 22.5 points (-130 at FanDuel Sportsbook).
Eagles vs. Buccaneers Injury Report & Latest News
We just mentioned the WR injuries for Philly, and they are some of the most significant of the entire NFL. Here is the latest injury news after Thursday’s practices before locking in your Eagles vs. Buccaneers picks:
PHI Eagles
- WR A.J. Brown (hamstring) - DNP
- OT Lane Johnson (concussion) - DNP
- WR DeVonta Smith (concussion) - DNP
- DT Milton Williams (groin) - LP
TB Buccaneers:
- RB Bucky Irving (hamstring) - DNP
- DT Calijah Kancey (calf) - DNP
- TE Ko Kieft (ankle) - DNP
- S Antoine Winfield (foot) - DNP
- WR Mike Evans (knee) - LP
- NT Greg Gaines (ankle) - LP
- DL William Gholston (knee) - LP
- WR Chris Godwin (neck) - LP
- WR Kameron Johnson (ankle) - LP
- NT Vita Vea (knee) - LP
- OT Tristan Wirfs (knee) - LP
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Player News
Colorado CB/WR Travis Hunter said NFL teams he’s met with during the pre-draft process have no issue with him playing both sides of the ball.
Hunter said he would refuse to play for a team that did not allow him to play both corner and wideout. “Because I’ve been doing it my whole life, and I love being on the football field,” he told CBS Sports. “I feel like I could dominate on each side of the ball, so I really enjoy doing it.” Hunter in 2024 played 713 offensive snaps and 748 defensive snaps, “which made him the only player since at least 2017 with at least 250 snaps played on both offense and defense in a single season,” according to CBS Sports Research. Colorado head coach Deion Sanders, a mentor to Hunter, said Hunter could easily play both sides of the ball as a pro since physical contact in the NFL is “minimal.” Pro Football Focus graded Hunter as last season’s second best cover corner. The most likely outcome for Hunter, 21, would include a full-time defensive role in the NFL with a package of receiver snaps in certain situations. He’s expected to go in the first ten picks of the 2025 draft.
The Athletic’s Dianna Russini reports Louisville QB Tyler Shough could be taken in the first round of the 2025 NFL Draft.
Russini said Shough’s draft prospects have spiked over the past two weeks, going from a second or third round selection to a possible first rounder. That, of course, depends on how desperate quarterback-needy teams will be on the first night of the NFL Draft. An anonymous head coach told Russini that Shough, who threw for nearly 3,200 yards, 23 touchdowns, and six interceptions in his final collegiate season, is the best QB prospect in the entire 2025 draft class. Shough, who will be 26 in September, played seven years of college football, including stints at Texas Tech and Oregon. Pro Football Focus graded Shough as 2024’s fifth best passer. His adjusted completion rate in 2024 ranked 25th out of 93 qualifying QBs. It would be surprising if a team aggressively pursued a questionable, older QB prospect as a first-round selection.
ESPN’s Adam Schefter reports Shedeur Sanders on Thursday will hold “one last private workout” for representatives from the Giants.
It appears the Giants are very much considering using their first rounder on Sanders, whose draft prospects are all over the place in the run-up to the 2025 NFL Draft. “When this happens so late in the process either there’s a big disagreement in their building on their evaluation or their reacting to new information,” said former Jets GM and current ESPN analyst Mike Tannenbaum. Sanders could go in the top five picks or drop out of the first round depending on how the Giants, Browns, and other QB-needy teams approach the first night of the draft. It remains to be seen if Sanders, who threw 64 touchdowns in two seasons on his father’s Colorado team, would compete with Jameis Winston and Russell Wilson for New York’s Week 1 starting job.
NFL Network’s Ian Rapoport reports the Dolphins and CB Jalen Ramsey are exploring trade options.
Rapoport added that “it wouldn’t be a surprise if [Ramsey] played elsewhere in 2025.” The Dolphins owe Ramsey $25.1 million in 2025, and don’t seem eager to keep him onboard after an underwhelming two seasons in Miami. Ramsey has five interceptions for the Dolphins over 27 games, missing significant time with various injuries, including a lingering knee issue. Ramsey in 2024 was graded by Pro Football Focus as the league’s 24th best cover corner out of 133 qualifying cornerbacks. Entering his age-31 seasons, Ramsey should get a decent amount of interest in the trade market in the coming weeks.
ESPN’s Ryan McFadden reports Jakobi Meyers is “open” to an extension with the Raiders.
Meyers is entering the final year of a three-year, $33 million contract signed in the 2023 offseason and coming off an 87/1027/4 receiving line in 2024. McFadden writes that the team views Meyers as a “key player” on the roster. Meyers could probably come close to a $20 million AAV in a new contract given the way the market is trending — that’s about what Stefon Diggs got from the Patriots this offseason after a lengthy wait.
The Athletic’s Nate Taylor writes that the Chiefs “need a young, dynamic running back to pair with” Isiah Pacheco.
Rarely do you see a beat writer go with the word “need,” but here we are. Kansas City clearly had no juice in the running game all last season as Pacheco struggled to run the same after returning from a broken leg. Kareem Hunt was a steady veteran pounder but couldn’t hit a second gear. Taylor notes that Brett Veach has been quoted as saying running backs in Andy Reid’s offense “need to be a better receiver than a runner” and ties them to Georgia back Trevor Etienne.