Cowboys vs. Giants Predictions, Picks & Odds: Thursday Night Football, 9/26

After back-to-back AFC East rivalries on Thursday Night Football, Week 4 kicks off with nearly the same, except an NFC East rivalry this time. The New York Giants are hosting the Dallas Cowboys, which many fans had as a matchup of the first and last place teams in the division heading into the year.
No matter how you feel about that thought, we’re here to provide our best Cowboys vs. Giants predictions for this matchup. Once you’re ready to lock in your Cowboys vs. Giants picks, you’ll also be able to do so with a guaranteed $200 DraftKings Sportsbook sign up bonus, which we’ll also share with you!
Cowboys vs. Giants Predictions For Thursday Night Football, NFL Week 4
The Cowboys steal the spotlight seemingly 99% of the time thanks to being dubbed America’s team and a polarizing owner in Jerry Jones, and now after back-to-back poor performances, they’re truly snatching headlines. Oh, the Giants also have the New York media hovering over their shoulders at all times.
Both these teams faced AFC North opponents this past Sunday, one coming off a win and one off a loss. However, it was not the ones you’d expect, which is what makes this Thursday Night Football game even more exciting. Is the change of scenery all the Cowboys need to bounce back? Can the G-Men move forward with momentum?
That’s what the best bet from our Cowboys vs. Giants predictions is here to help answer once we discuss each team and look at the latest Cowboys vs. Giants odds to provide you with the best value.
Dallas Cowboys: Blocking Out The Noise
Between the aforementioned Jerry Jones, the outspoken Micah Parsons and Dak Prescott always being hounded by the media, there is virtually no escape for the Cowboys. However, it comes with the territory, and they’re going to need to block out the noise on such a short week.
Frankly, having another game sooner rather than later means less time for them to be ridiculed, and hopefully for their sake, provides positives to talk about. Given their history with the G-Men, signs are pointing in that direction, which certainly plays a role in the best bet from our Giants vs. Cowboys predictions.
New York Giants: Ride The Momentum
We mentioned it already, but the Giants truly need to do everything in their power to build on last week’s win over the Cleveland Browns. Heading into Week 3, they were considered the absolute worst team in the league by plenty of fans and analysts alike, and they were underdogs of more than a touchdown.
Truthfully, the Browns offense has proven to be quite subpar, especially in the red zone, so we aren’t exactly buying into New York just yet. However, the team certainly needs to, so a home upset win over a division rival would be the best way to turn their season around.
Cowboys vs. Giants Odds, Spreads, Total & Betting Lines
We say upset as New York is the clear underdog despite being at home, and you can see the latest Cowboys vs. Giants odds at DraftKings Sportsbook:
- Point Spread: Dallas Cowboys -4.5 (-110) vs. New York Giants +4.5 (-110)
- Money Line: Dallas Cowboys (-205) vs. New York Giants (+170)
- Game Total (Over/Under): Over 44 (-110) vs. Under 44 (-110)
Cowboys vs. Giants Predictions: Dallas Team Total Over 24.5 Points (-108 at DraftKings Sportsbook)
All the media backlash for the Cowboys recent losses has only provided more value in the betting markets for those liking Dallas, as it’s forced most to be down on their stock right now. Well, while we have an overall best bet, we’d target Dallas in all ways possible with your Cowboys vs. Giants picks.
We’d snag the point spread at anything under six points or even a touchdown, under the Giants team total and of course, over the Cowboys team total. Dallas’ defense is certainly not great, but that has the New York team total inflated in comparison to their actual offensive production.
Regardless, with this being a classic NFC East rivalry, we have plenty of data to pull from. Of course, every year is different, so we can’t put all our eggs in that basket, but it’s still important to understand the utter domination the ‘Boys have had over the G-Men.
Over their last 10 meetings, Dallas has covered the spread in seven of them, but we’re more focused on just how significantly they’ve done so. In their two meetings last season, the Cowboys won 40-0 and 49-17, the former of which was also in prime time on Sunday Night Football.
In that same span, they’ve scored 40+ three times, 35+ six times and 28+ seven times. We also alluded to being out of AT&T Stadium is actually great news for the Cowboys - they’ve allowed 40 points per game and 7.7 yards per play in their last three home games. When they began the season on the road, they blew out the Browns 33-17 as underdogs.
There are so many ways to approach this matchup, but we’ll lock in a best bet from our Cowboys vs. Giants predictions on Dallas’ team total over 24.5 points (-108 at DraftKings Sportsbook).
Cowboys vs. Giants Injury Report & Latest News
We don’t have as much practice information this early in the week, but for now, here is the latest Cowboys vs. Giants injury news:
DAL Cowboys:
- S Markquese Bell - DNP
- CB Caelen Carson - DNP
- DE DeMarcus Lawrence - LP
NY Giants:
- CB Adoree' Jackson - DNP
- CB Dru Phillips - DNP
- DL Dexter Lawrence - LP
- CB Nick McCloud - LP
- ILB Micah McFadden - LP
- WR Darius Slayton - LP
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Player News
Packers signed WR Bo Melton, RB Emanuel Wilson, and P Daniel Whelan to their exclusive rights free agent tenders.
Melton caught on with the Packers in 2023, totaling 16 receptions for 218 yards and a touchdown in five games. He added eight receptions for 91 yards in 17 games last season. Melton will continue to be a depth piece in an already-deep Packers wide receiver room. Wilson has also been with the Packers for two seasons and rushed for 502 yards and four touchdowns as Josh Jacobs’ immediate backup last season. He will compete with MarShawn Lloyd for that role again. Whelan is the team’s punter and will be back for 2025. All three signed their exclusive rights free agent tender and will essentially be on one-year contracts this season.
Seahawks re-signed Johnathan Hankins to a one-year contract.
Hankins hasn’t had a PFF run defense grade above 52.4 since 2020 and is primarily called on to play early downs. He turned 33 in March. He’ll be a complimentary piece behind Jarran Reed and Byron Murphy II if he makes the roster out of training camp.
Chargers placed the UFA tender on RB J.K. Dobbins.
This gives the Chargers exclusive negotiating rights if he does not sign with a team by July 22 or the first 2025 NFL training camp opens, whichever comes first. The tag is mainly useful for compensatory pick reasons as Dobbins will still count towards Los Angeles’ haul in the formula if signed before then. The Chargers currently do not project to add a pick in 2026 per Over The Cap’s Nick Korte.
49ers signed OT D.J. Humphries.
Humphries played in only two games for the Chiefs last year as he spent most of the season rehabbing a late 2023 torn ACL on his own. He wasn’t appreciably good in either of those games, but he was rusty and does have a history of better than that. Entering his age-32 season for the 49ers, he’ll probably be trying to win the right tackle job opposite Trent Williams in training camp.
Patriots released LS Joe Cardona.
The team selected his replacement, Julian Ashby, in the seventh round of the draft. This snapper of balls who are longer than usual is only 33, and it’s possible he picks up his career elsewhere. There aren’t too many remaining Patriots Regimes in the wild in 2025, but Nick Caserio does still run the Texans and they let Jon Weeks walk this offseason so that’s one speculative fit.
NewOrleans.Football’s Nick Underhill said he would be “flabbergasted” if Derek Carr played for the Saints this year.
“I would have trouble understanding why you would allow that to happen, you’re trying to build a new culture, you can’t let that guy ... you just got a rookie QB, this is the example you’re going to give him,” Underhill continued. Both Underhill and Mike Triplett believe Tyler Shough will be starting for the Saints in Week 1, with Underhill saying he had “80 percent or higher odds to start 80 percent of the games this year.” Shough would be an uninspiring superflex pick, perhaps a QB3, but given how things have played out with Carr over the past months it sure doesn’t seem like the Saints have a reason to want to continue this relationship. Mickey Loomis literally asked reporters to stop asking him Carr questions at his pre-draft press conference.