Saints vs. Cowboys Predictions, Picks & Odds: NFL Week 2, Sunday 9/15

Two of the teams that had the most dominating wins of NFL Week 1 were the New Orleans Saints and Dallas Cowboys, and now, they find themselves up against each other for Week 2. That makes this clash even more exciting, and who knows, perhaps it could even impact NFC seeding come the end of the season!
That’s why we’re here to arm you with our Saints vs. Cowboys predictions, and better yet, how to use them to claim a generous BetMGM Sportsbook welcome offer worth up to $1,500!
Saints vs. Cowboys Predictions for NFL Week 2, Sunday 9/15
Heading into Week 1, the Cowboys matchup with the Cleveland Browns was considered the game of the week, and it wasn’t just because they’re America’s team. In fact, oddsmakers were doubting them, as they were nearly field-goal underdogs.
Despite that, they cruised through Cleveland, but it almost pales in comparison to what the Saints did to Carolina. They absolutely punished the Panthers, pouncing out to a 30-0 halftime lead, and ultimately, a 47-10 win.
New Orleans and Dallas displayed two of the best defenses in the NFL last season, but there were question marks heading into this year after an offseason of losses. Now, the question is whether we can buy into what we saw in Week 1 or if we should expect those absences to show themselves now facing one another.
New Orleans Saints: Week 1 Fluke Or Reason To Believe?
Starting with the Saints, can we really believe what we saw in Week 1? Let’s not forget, the Carolina Panthers finished last season with a league-worst 2-15 record and did very little this offseason to prove themselves as doing anything but continuing to rebuild.
That includes an undersized second-year QB behind a terrible offensive line, whereas New Orleans will be facing the now highest-paid signal caller with $231 million guaranteed to Cowboys QB Dak Prescott. It’s going to be a totally different beast, which is absolutely going to play a part in the best bet from our Saints vs. Cowboys predictions.
Dallas Cowboys: Dominant Defense Despite Losses
When we mentioned that these teams suffered defensive losses this offseason, Dallas had perhaps the most significant of the entire NFL. That included three defensive lineman, star LB Leighton Vander Esch and CB Stephon Gilmore.
Even with those losses, the Cowboys defense forced the Browns to either zero or negative yards on 43% of their plays! So, the question then becomes whether or not Cleveland QB Deshaun Watson is simply washed up, or if Dallas really is that dominant. Only time will tell, but seeing pass rusher Micah Parsons record eight defensive pressures himself is quite impressive.
Saints vs. Cowboys Odds, Spreads, Total & Betting Lines
We promised a best bet from our Saints vs. Cowboys predictions, but first, the latest Saints vs. Cowboys odds at BetMGM Sportsbook:
- Point Spread: New Orleans Saints +6.5 (-110) vs. Dallas Cowboys -6.5 (-110)
- Money Line: New Orleans Saints (+240) vs. Dallas Cowboys (-300)
- Game Total (Over/Under): Over 45.5 (-115) vs. Under 45.5 (-105)
Saints vs. Cowboys Over 45.5 Points (-115 at BetMGM Sportsbook)
That’s right, we’re going against the grain when it comes to our Saints vs. Cowboys predictions. Most of the discussion surrounding these teams has been their defense, including us thus far. However, that’s why we have a total under one of the most key numbers of 47, and BetMGM is a full point lower than some other sportsbooks.
Regardless, we’re expecting a 27-21 type of game, which would be nearly spot-on with the projected point spread as well. Given that it’s hovering around the key number of seven, that is another reason why we’re focusing on the total with our Saints vs. Cowboys picks instead.
It can undoubtedly be difficult not to overreact to what we saw in Week 1, but it’s only that - just one week. Expecting the Saints to pull off the same type of performance against the Cowboys, a 12-win team the past three seasons, as the 2-15 Panthers seems a bit far-fetched. Similarly, the Browns simply looked out of sync with Watson and head coach/play caller Kevin Stefanski.
We’re not saying to expect a shootout, but over 45.5 points (-115 at BetMGM Sportsbook) is the top pick from our Saints vs. Cowboys predictions.
Saints vs. Cowboys Injury Report & Latest News
We’ve discussed big names and offseason losses alike, and we also have the latest Saints vs. Cowboys injury news as well:
NO Saints:
- TE Foster Moreau (Questionable)
- TE Dallin Holker (Questionable)
- T Taliese Fuaga (Questionable)
- LB Jaylan Ford (Questionable)
- DT Khalen Saunders (Questionable)
- G Lucas Patrick (Questionable)
- S Tyrann Mathieu (Questionable)
- CB Marshon Lattimore (Questionable)
- LB D’Marco Jackson (Questionable)
DAL Cowboys:
- G Zack Martin (Questionable)
- DE DeMarcus Lawrence (Questionable)
- LB Erik Kendricks (Questionable)
- WR Brandin Cooks (Questionable)
- CB C.J. Goodwin (Questionable)
- TE John Stephens (Questionable)
- TE Jake Furguson (Questionable)
- DE Marshawn Kneeland (Questionable)
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Player News
ESPN’s Jeremy Fowler reports that the Jaguars will not exercise the fifth-year option on LB Devin Lloyd.
The option would have guaranteed Lloyd $14.751 million for the 2026 season. Lloyd, who was the 27th overall pick in 2022, has started 46 of 48 games with the Jaguars since his arrival. In 2024, Lloyd had 113 tackles, two sacks, an interception, and a forced fumble. According to PFF, Lloyd has been the Jaguars’ highest-graded linebacker over the past two seasons.
The Athletic’s Mike DeFabo listed Steelers rookie RB Kalenb Johnson alongside Jaylen Warren as co-starters.
Johnson, described by DeFabo as a “physical back built to carry the load,” was taken with the 83rd overall pick in the 2025 NFL Draft. He’s widely expected to replace Najee Harris — now with the Chargers — in the Pittsburgh backfield in 2025. Johnson dominated the Iowa backfield in 2024, totaling 240 carries for 1,537 yards and 21 touchdowns. He made progress as a pass catcher, reeling in 22 balls for 188 yards and a pair of touchdowns in the run-heavy Iowa offense. Only three running backs in the nation logged more rushes of over ten yards than Johnson in 2024. His presence, along with Kenneth Gainwell, leaves little upside for Warren barring backfield injuries for the Steelers.
Sports Illustrated’s Terrance Biggs believes Falcons WR Nick Nash could “work his way” into the team’s wideout rotation.
Biggs said the 25-year-old undrafted free agent out of San Jose State who in 2024 led all college receivers in catches, yards, and touchdowns could make an impact in offseason workouts and training camp and find his way into a role in the Atlanta offense. “With time,” Biggs said, “you can see Nash work his way into the rotation, earning his keep on special teams and four/five receiver sets.” Nash’s lack of explosiveness and long speed will be tough to overcome, but precise route running and sure hands for the QB-turned-wideout could earn Nash a roster spot this summer. For now, Drake London, Ray-Ray McCloud, and Darnell Mooney sit atop the Atlanta receiver depth chart.
Eagles exercised the fifth-year option for DT Jordan Davis.
After Eagles general manager Howie Roseman in mid-April declined to say whether the team would pick up Davis’ option, the team made the call following Davis played his second straight 17-game season for the dominant Philly front seven. Davis, who has 3.5 sacks and five tackles for loss over his past two seasons, was graded by Pro Football Focus as 2024’s 40th best defensive tackle. He will make $12.9 million in the 2026 season.
The Athletic’s Zack Rosenblatt believes RB Donovan Edwards will make the Jets roster.
Edwards, who signed with New York as an undrafted free agent after the 2025 NFL Draft, faces an uphill battle to make the final roster behind Breece Hall, Braelon Allen, and Isaiah Davis. Rosenblatt said “Edwards’ pass-catching skills are his best path to the roster” after the back totaled 86 receptions in four years in college, at 9.3 yards per reception. The highly-athletic Edwards excelled in some big spots for Michigan over the years but never fully emerged as the player many expected to see after his stellar 2022 campaign. If he makes the New York roster, Edwards would likely operate as a special teamer or pass-catching specialist out of the backfield.
Packers signed WR Bo Melton, RB Emanuel Wilson, and P Daniel Whelan to their exclusive rights free agent tenders.
Melton caught on with the Packers in 2023, totaling 16 receptions for 218 yards and a touchdown in five games. He added eight receptions for 91 yards in 17 games last season. Melton will continue to be a depth piece in an already-deep Packers wide receiver room. Wilson has also been with the Packers for two seasons and rushed for 502 yards and four touchdowns as Josh Jacobs’ immediate backup last season. He will compete with MarShawn Lloyd for that role again. Whelan is the team’s punter and will be back for 2025. All three signed their exclusive rights free agent tender and will essentially be on one-year contracts this season.