Thunder vs. Grizzlies Predictions, Picks & Odds: NBA Playoffs Game 2, 4/22

The Oklahoma City Thunder look to take a commanding 2-0 lead in their Western Conference first-round playoff series against the Memphis Grizzlies Today, April 22, 2025.
Thunder vs. Grizzlies Predictions for NBA Playoffs Game 2 on TNT, 4/22
After a dominant 51-point victory in Game 1 (131-80), the Thunder aim to maintain their momentum at home, while the Grizzlies hope to rebound from a historically lopsided loss.
Here’s a breakdown of the key storylines, betting odds, Thunder vs. Grizzlies predictions, and how to watch and bet on this exciting matchup.
Oklahoma City Thunder: Rest Advantage & Defensive Dominance
The Thunder, the No. 1 seed in the West with a 68-14 record, showcased their elite defense and offensive firepower in Game 1. Led by Shai Gilgeous-Alexander, who struggled offensively yet still saw his team cruise, the Thunder capitalized on Memphis’ fatigue after a grueling play-in schedule.
The Thunder’s defensive stifled the Grizzlies, holding them to just 80 points. With a full week of rest before Game 1 and another two days to prepare for Game 2, Oklahoma City is poised to continue exploiting their home-court advantage at the Paycom Center, where they went 35-6 during the regular season.
The storyline to watch for Thunder vs. Grizzlies predictions is whether the Thunder’s depth, with healthy bigs Chet Holmgren and Isaiah Hartenstein, can maintain their suffocating defense and keep Memphis’ high-paced offense in check.
Memphis Grizzlies: Ja Morant’s Response & Avoiding A Deep Hole
The No. 8-seeded Grizzlies (48-34) were shell-shocked in Game 1, suffering their worst playoff loss in franchise history. Ja Morant, playing through a lingering ankle sprain, managed only 17 points in 26 minutes, while the team struggled to find rhythm against Oklahoma City's elite defense. Memphis, the league’s fastest-paced team, relies on Morant’s explosiveness and contributions from Jaren Jackson and Desmond Bane to generate offense.
After a short turnaround from their play-in win over Dallas, the Grizzlies should benefit from a couple of days’ rest, but they face an uphill battle against a Thunder team that swept them 4-0 in the regular season by an average margin of 18.75 points. The key storyline is whether Morant can elevate his scoring (23.2 PPG this season) and if rookie center Zach Edey can dominate the glass to give Memphis a fighting chance.
Thunder vs. Grizzlies Odds, Spreads, Total & Betting Lines
Here are the latest Thunder vs. Grizzlies odds for Game 2, courtesy of DraftKings Sportsbook (odds subject to change):
- Spread: Thunder -14.5 (-110) | Grizzlies +14.5 (-110)
- Moneyline: Thunder -1050 | Grizzlies +675
- Over/Under: 229.0 points (-110)
- Implied Totals: Thunder 122, Grizzlies 107.5
The Thunder opened as 14.5-point favorites, reflecting their Game 1 dominance and Memphis’ struggles. The total has ticked up slightly from 227.5 in Game 1 to 229.0, despite the blowout, as oddsmakers expect a more competitive game. The Thunder covered the 13.5-point spread in Game 1 with ease. Can they do it once again?
Thunder vs. Grizzlies Best Bet: Memphis Team Total Over 106.5 (-115 on DraftKings Sportsbook)
For our Thunder vs. Grizzlies picks, the Memphis Grizzlies are one of the best offensive teams in the Association and although they were held to just 80 points in game one, they should exceed their projected team total tonight. First off, they played two tough matches within a short timeframe, and a 12:00 P.M. local start time after a Friday night game would have been tough on any team… but that’s why teams avoid eighth place.
Memphis averaged 121.7 points per game this season, and as great as the Thunder’s defense is, the Grizzlies should score over 106.5 points. Edey will need to step up and be an active scorer in the paint.
Once that happens Memphis can cut and use angles to help create space from Chet Holmgren and Isaiah Hartenstein. Memphis is well rested, and Morant is an elite offensive player who will find ways to score and get others involved. Put a unit on the Grizzlies to score far more points tonight in today’s Thunder vs. Grizzlies predictions.
How To Watch Thunder vs. Grizzlies on TNT Today
- Date: Tuesday, April 22, 2025
- Time: 7:30 p.m. ET
- Location: Paycom Center, Oklahoma City, OK
- TV: TNT
- Streaming: Max (with B/R Sports add-on), Sling TV, or NBA League Pass (for on-demand access)
- Radio: ESPN Radio, local stations (WWLS 98.1 FM for OKC, WMFS 92.9 FM for Memphis)
Thunder vs. Grizzlies Injury Report & Starting Lineup
Injury Report
- Thunder:
- Out: Ousmane Dieng (left calf strain)
- Out: Ousmane Dieng (left calf strain)
- Grizzlies:
- No injuries reported
Morant is dealing with a minor ankle injury but there is nothing listed on the official injury report.
Projected Starting Lineups
- Thunder: Shai Gilgeous-Alexander (PG), Luguentz Dort (SG), Jalen Williams (SF), Chet Holmgren (PF), Isaiah Hartenstein (C)
- Grizzlies: Ja Morant (PG), Desmond Bane (SG), Vince Williams (SF), Jaren Jackson (PF), Zach Edey (C)
Lineups are subject to change based on injury updates.
How To Bet On Thunder vs. Grizzlies at DraftKings Sportsbook & Claim Your $200 Bonus
Ready to make Thunder vs. Grizzlies predictions? DraftKings Sportsbook offers a seamless betting experience and a generous welcome bonus for new users. Here’s how to get started and claim your $200 in bonus bets:
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- Claim Your Bonus: Once your qualifying bet is placed, you’ll receive $200 in bonus bets, win or lose, delivered as eight $25 bonus bets (must be used within 7 days).
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DraftKings provides competitive odds, live betting, and player prop markets like Shai Gilgeous-Alexander over 32.5 points (+100) or Ja Morant over 7.5 assists (-110). Check the DraftKings app for real-time odds and additional promotions, such as Same Game Parlays or boosted odds for Thunder vs. Grizzlies predictions in Game 2.
Bet Smart, Be Lucky - Iggy -
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