PrizePicks MLB DFS Picks Today, 9/22: Expert Picks, Projections & More
On Sunday, September 22nd, we have a massive 16-game MLB slate. That will allow us to pinpoint elite PrizePicks MLB DFS Picks Today and elite plays we will find!
Two of our early favorites are Kyle Tucker of the Houston Astros and Julio Rodriguez of the Seattle Mariners. With how much baseball there is today, there are numerous opportunities when looking at today’s MLB DFS projections!
PrizePicks MLB DFS Today, Sun, 9/22: MLB DFS Projections
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Kyle Tucker PrizePicks MLB Pick: More Than 1.5 Hits+Runs+RBI
Since Kyle Tucker has returned, he’s done nothing but crush opposing pitching and has added incredible depth to the Astros lineup. He’s hitting .405 in September through his first 13 games and this line of 1.5 Hits+Runs+RBI is too low, making him one of my favorite PrizePicks MLB DFS Picks Today. The Astros are one of five teams with at least five implied runs and Tucker is at the forefront of that. He has 18 combined runs and RBI since returning and has 17 hits in 13 games too. He faces Griffin Canning who’s allowed a .204 ISO and .356 wOBA against left-handed hitters. Tucker himself has casual marks of a .369 ISO and .470 wOBA against righties.
- Pick: More Than 1.5 Hits+Runs+RBI
Julio Rodriguez PrizePicks MLB Pick: More Than 8 Hitter Fantasy Score
We have a bunch of things working in our favor which puts him on our radar as one of the better PrizePicks MLB DFS Picks Today. First off, he’s ending his season on an absolute tear as he’s batting .345 with a .970 OPS and .405 wOBA. He’s been an elite hitter on the road this season posting a .302 AVG compared to a .241 mark at home. He also hits lefties well posting a .281 AVG, .779 OPS, and .339 wOBA. Over the last 30 days, Andrew Heaney has had luck on his side and that comes to an end today. He has allowed just a .152 ISO and .315 wOBA to righties over that span, but the expected numbers come in at .200 and .364 respectively.
- Pick: More Than 8 Hitter Fantasy Score
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Player News
Daulton Varsho picked up three hits, three RBI and a homer in a win over the Angels on Thursday.
Varsho has only played in seven games this year, but they’ve been seven good ones. He’s homered three times already, and his slugging percentage is a remarkable — and entirely unsustainable — .727 over 22 at-bats. Varsho has been a mediocre offensive player in his two seasons with the Blue Jays, but it’s possible at the age of 28 he’s having a breakout campaign. Far from a guarantee, but possible.
Taylor Ward hit a two-run homer in a loss to the Blue Jays on Thursday.
Ward, 31, gave the Angels a 2-0 lead with a two-run homer off Chris Bassitt in the first inning. He’s now gone deep in two of his last three games, and it ‘improves’ his slash to .181/.224/.391. Ward has been one of the most hot/cold players players in the sport over the last few years, so fantasy managers who can afford to make some roster moves may want to look at Ward while the going is good.
Vladimir Guerrero Jr. picked up three hits and scored twice in an 8-5 win over the Angels on Thursday.
Guerrero also drew a walk. It gives the first baseman multiple hits in back-to-back games, and it’s the third time in May that he’s reached that mark. That’s helped raise his average from .268 to .295, and the only thing fantasy managers can be disappointed with is his .432 slugging percentage. That number should continue to climb as the season unfolds, but Vladdy Jr. has had some inconsistent seasons when it comes to power production.
Chad Green picked up his first save of 2025 with a scoreless ninth against the Angels on Thursday.
Green got the save after Jeff Hoffman worked in back-to-back games — and struggled — in the first two contests against the Angels. He struck out two and looked the part while needing just nine pitches to get through the inning. Hoffman should remain the closer, but Green is on his tail if the struggles were to continue.
Chris Bassitt allowed five runs — four earned — while working six-plus innings against the Angels on Thursday while picking up a win.
Bassitt allowed three runs over the first two innings on a pair of homers, but settled down over his next four frames. He came out to work the seventh, but ended up being charged for two more runs after leaving the contest. The 36-year-old veteran has forged a 3.35 ERA and outstanding 49/8 K/BB ratio over the first quarter of the season, but this wasn’t him at his best. He’ll get the Rays next week if the rotation order stays the same for Toronto.
José Soriano allowed three runs over five innings while not factoring in the decision Thursday against the Blue Jays.
Soriano left with a 4-3 lead, but it was erased quickly after his departure. The 26-year-old was not exactly dominant in his outing with eight hits allowed and four free passes, but he did strike out six to help balance things out a smidgen. Soriano takes an even ERA of 4.00 into a scheduled start against the Padres in San Diego on Tuesday. There should be better options for that one.