Welcome back to another Sunday of MLB picks as we take a closer look at all of today’s games. Let’s dive into MLB Best Bets and Props as you enjoy the weekend action!

Our top MLB predictions today feature Rockies vs. Dodgers picks in an NL West divisional showdown. Plus, we wrap up our Sunday baseball betting card with some top MLB props today. Enjoy the weekend baseball as we cash our plays! 

 

 


 

MLB Picks, Predictions & Best Bets Today, 9/22

As always, be sure to shop around for the best Vegas Odds and Lines at different sportsbooks. The odds in this article below are accurate as of this writing. 

Without further ado, let’s check out my MLB best bets and props for Sunday, September 22nd.

 

 


 

Rockies vs. Dodgers Prediction: Sunday, September 22nd

Our first MLB picks today feature an NL West matchup between the Los Angeles Dodgers and Colorado Rockies. Considering the starting pitchers and the quality of offenses on both sides here, the Dodgers should have a notable advantage on Saturday night. 

Antonio Senzatela starts for Colorado and it could be a shaky outing. Senzatela made his 2024 debut this past Monday after recovering from Tommy John surgery. He allowed 2 runs, 4 hits, and 2 walks over 3 innings. If he pitched deeper into the game, it could’ve been a much worse pitching line. Senzatela had a 5.29 ERA across 5 rehab minor-league outings

This is a tough road spot as the Dodgers are a top-10 offense against righties over the past two weeks (.315 wOBA, 104 wRC+). Senzatela, meanwhile, has a career 5.98 ERA against the Dodgers (64.2 innings) and a 5.97 ERA in 8 career outings at Dodger Stadium. The Rockies’ righty also has a 5.22 ERA in his career on the road. All signs are pointing towards LA getting to Senzatela here. 

On the other side, Yoshinobu Yamamoto should handle the subpar Rockies offense. Yamamoto has looked good since returning to the Dodgers rotation this month, allowing zero earned runs over 8 combined innings. The right-hander now has a 0.39 ERA over his past 5 outings and a 2.17 ERA over his past 10 starts. Colorado has struggled vs. righties recently (.285 wOBA, 69 wRC+, 27.6% K rate over past two weeks). 

Take the Dodgers on the runline for the full game and first five innings. If you’re scared off the runline for a home favorite, just consider this: The Dodgers are 6-2 against the Rockies this year with all 6 wins coming by multiple runs. Plus, 18 of the last 19 wins overall for Los Angeles have been by 2+ runs. Take the over on the Dodgers team total as well. 

Expert Rockies vs. Dodgers MLB Picks

  • Los Angeles Dodgers -1.5 Runline (-155 DraftKings Sportsbook)
  • 1st 5 Innings Dodgers -1.5 RL (-110 BetMGM)
  • Dodgers Team Total Over 5.5 Runs (+100 BetMGM)

 

 


 

Best MLB Player Prop Bets & Other Picks Today, 9/22

  • Twins/Red Sox Game 1 Under 7.5 Total Runs (-105 BetMGM)
  • Darren McCaughan (MIA) Over 5.5 Hits Allowed (+120 DraftKings Sportsbook)
  • Phillies/Mets Over 6.5 Total Runs (-125 BetMGM)
  • Hunter Greene (CIN) 5+ Strikeouts (+105 DraftKings Sportsbook)