TeamRB1RB2RB3INJ/SUS
Arizona CardinalsAdrian PetersonAndre EllingtonKerwynn WilliamsDavid Johnson
Atlanta FalconsDevonta FreemanTevin ColemanTerron Ward 
Baltimore RavensJavorius AllenAlex CollinsTerrance WestDanny Woodhead
Buffalo BillsLeSean McCoyMike TolbertJoe Banyard 
Carolina PanthersJonathan StewartChristian McCaffreyFozzy Whittaker 
Chicago BearsJordan HowardTarik CohenBenny Cunningham 
Cincinnati BengalsJoe MixonGiovani BernardJeremy Hill 
Cleveland BrownsIsaiah CrowellDuke JohnsonMatthew Dayes 
Dallas CowboysEzekiel ElliottDarren McFaddenAlfred Morris 
Denver BroncosC.J. AndersonJamaal CharlesDevontae Booker 
Detroit LionsAmeer AbdullahTheo RiddickZach Zenner 
Green Bay PackersTy MontgomeryAaron JonesJamaal Williams 
Houston TexansLamar MillerD'Onta ForemanAlfred Blue 
Indianapolis ColtsFrank GoreMarlon MackRobert Turbin 
Jacksonville JaguarsLeonard FournetteChris IvoryT.J. Yeldon 
Kansas City ChiefsKareem HuntCharcandrick WestAkeem HuntSpencer Ware
Los Angeles ChargersMelvin GordonBranden OliverAustin Ekeler 
Los Angeles RamsTodd GurleyMalcolm BrownJustin DavisLance Dunbar
Miami DolphinsJay AjayiDamien WilliamsKenyan Drake 
Minnesota VikingsJerick McKinnonLatavius MurrayCJ HamDalvin Cook
New England PatriotsMike GillisleeJames WhiteRex Burkhead 
New Orleans SaintsMark IngramAlvin KamaraTrey Edmunds 
New York GiantsOrleans DarkwaWayne GallmanShane Vereen 
New York JetsBilal PowellMatt ForteElijah McGuire 
Oakland RaidersMarshawn LynchDeAndre WashingtonJalen Richard 
Philadelphia EaglesLeGarrette BlountWendell SmallwoodCorey ClementDarren Sproles
Pittsburgh SteelersLe'Veon BellJames ConnerTerrell Watson 
San Francisco 49ersCarlos HydeMatt BreidaRaheem Mostert 
Seattle SeahawksEddie LacyThomas RawlsC.J. ProsiseChris Carson
Tampa Bay BuccaneersDoug MartinJacquizz RodgersCharles Sims 
Tennessee TitansDeMarco MurrayDerrick HenryDavid Fluellen 
Washington RedskinsRobert KelleyChris ThompsonSamaje Perine 

Top Handcuffs

Marlon Mack, IND- There was a lot of preseason hype surround Mack heading into the season but Frank Gore has been able to hold onto the starting job through six weeks but in Week 5 Mack rushed for 91 yards and a touchdown which has prompted the coaching staff to indicate that he will be more involved in the offense moving forward.  While it will likely take an injury to completely leap Gore on the depth chart there is definite fantasy value here should he ulimtately split carries with Gore going forwad.

Matt Breida, SF- Carlos Hyde foudn himself benched for the majority of the 49ers Week 5 loss to the Colts which lead the way for rookie Matt Breida to take over as the team's lead back.  Breida carried the ball 10 times for 49 yards and added three catches for 22 yards with the increased role in the offense.  After the game head coach Kyle Shanahan stated that Hyde is still the team's starting running back but it appears he may be falling out of favor making Breida a must own handcuff.

Samaje Perine, WAS- News out of Washington is that Robert Kelley is unlikely to play in Week 6 against the 49ers which means rookie Samaje Perine will be the lead back for the Redskins coming out of the bye week.  Perine should handle all the early down work with Chris Thompson continuing to see the field on third and passing downs. On the season Perine has totaled 43 carries for 143 yards for an unimpressive 3.1 yards per carry however the 49ers are allowing the second most fantasy points to opposing running backs this season so this is a prime matchup for Perine to breakout.

TeamWR1WR2WR3INJ/SUS
Arizona CardinalsLarry FitzgeraldJohn BrownJ.J. Nelson 
Atlanta FalconsJulio JonesMohamed SanuTaylor Gabriel 
Baltimore RavensJeremy MaclinMike WallaceBreshad Perriman 
Buffalo BillsZay JonesAndre HolmesBrandon TateJordan Matthews
Carolina PanthersKelvin BenjaminDevin FunchessRussell Shepard 
Chicago BearsKendall WrightMarkus WheatonJoshua BellamyCameron Meredith
Cincinnati BengalsA.J. GreenBrandon LaFellJohn Ross 
Cleveland BrownsKenny BrittSammie CoatesRashard HigginsCorey Coleman
Dallas CowboysDez BryantCole BeasleyTerrance Williams 
Denver BroncosDemaryius ThomasEmmanuel SandersBennie Fowler III 
Detroit LionsGolden TateMarvin JonesKenny Golladay 
Green Bay PackersJordy NelsonDavante AdamsRandall Cobb 
Houston TexansDeAndre HopkinsWill FullerBruce Ellington 
Indianapolis ColtsT.Y. HiltonDonte MoncriefChester Rogers 
Jacksonville JaguarsMarqise LeeAllen HurnsArrelious BennAllen Robinson
Kansas City ChiefsTyreek HillChris ConleyAlbert Wilson 
Los Angeles ChargersKeenan AllenTyrell WilliamsTravis Benjamin 
Los Angeles RamsSammy WatkinsCooper KuppRobert Woods 
Miami DolphinsJarvis LandryDeVante ParkerKenny Stills 
Minnesota VikingsStefon DiggsAdam ThielenMichael Floyd 
New England PatriotsBrandin CooksChris HoganDanny AmendolaJulian Edelman
New Orleans SaintsMichael ThomasWillie SneadTed Ginn 
New York GiantsSterling ShepardRoger LewisTavarres KingOdell Beckham
New York JetsJermaine KearseJeremy KerleyRobby AndersonQuincy Enunwa
Oakland RaidersAmari CooperMichael CrabtreeSeth Roberts 
Philadelphia EaglesAlshon JefferyTorrey SmithNelson Agholor 
Pittsburgh SteelersAntonio BrownMartavis BryantJuju Smith-Schuster 
San Francisco 49ersPierre GarconMarquise GoodwinAldrick Robinson 
Seattle SeahawksDoug BaldwinPaul RichardsonTyler Lockett 
Tampa Bay BuccaneersMike EvansDeSean JacksonAdam Humphries 
Tennessee TitansRishard MatthewsEric DeckerCorey Davis 
Washington RedskinsTerrelle PryorJamison CrowderRyan Grant 

Top Handcuffs

Adam Humphries, TB- The Tampa Bay slot receiver is averaging five catches on seven targets for 63 yards over the last three weeks.  In PPR formats that is just over 11 fantasy points a game during that stretch.  With defenses worrying so much about the vertical passing game with Mike Evans and Desean Jackson fanasy owners should take notice of Humphries who is catching all of Jameis Winston's underneath throws and going relatively unnoticed as he sits under five percent owned in standard leagues.

Michael Floyd, MIN- Flyod made his return to the football field in Week 5 and caught his only pass for 19 yards. He is an interesting case heading into Week 6 with word that Stefon Diggs is questionable to suit up.  If Diggs ends up sitting out against the Packers then Floyd should see an increased snap count and could find himself involved in the team's passing attack as he takes over for Diggs as the team's outside receiver.

Sterling Shepard, NYG- Week 5 was a nightmare for the Giants as they lost all three starting receivers to injuries but only Sheppard managed to escape with a minor injury while Odell Beckham and Brandon Marshall both suffered season ending injuries.  Shepard is now the No.1 receiver for the Giants which skyrockets his fantasy value although his matchup against the Broncos in Week 6 is likely one you should avoid.

TeamTE1TE2TE3INJ/SUS
Arizona CardinalsJermaine GreshamTroy NiklasIfeanyi Momah 
Atlanta FalconsAustin HooperLevine ToiloloEric Saubert 
Baltimore RavensBenjamin WatsonNick BoyleMaxx Williams 
Buffalo BillsNick O'LearyLogan Thomas Charles Clay
Carolina PanthersEd DicksonChris Manhertz Greg Olsen
Chicago BearsZach MillerDion SimsAdam Shaheen 
Cincinnati BengalsTyler KroftC.J. Uzomah Tyler Eifert
Cleveland BrownsSeth DeValveDavid NjokuRandall Telfer 
Dallas CowboysJason WittenJames HannaGeoff Swaim 
Denver BroncosVirgil GreenJeff HeuermanA.J. Derby 
Detroit LionsEric EbronDarren FellsMichael Roberts 
Green Bay PackersMartellus BennettLance KendricksRichard Rodgers 
Houston TexansRyan GriffinStephen Anderson C.J. Fiedorowicz
Indianapolis ColtsJack DoyleDarrell DanielsBrandon Williams 
Jacksonville JaguarsMarcedes LewisBen KoyackJames O'Shaughnessy 
Kansas City ChiefsTravis KelceDemetrius HarrisRoss Travis 
Los Angeles ChargersHunter HenryAntonio GatesSean Culkin 
Los Angeles RamsTyler HigbeeGerald EverettDerek Carrier 
Miami DolphinsJulius ThomasAnthony FasanoMarQueis Gray 
Minnesota VikingsKyle RudolphDavid MorganBlake Bell 
New England PatriotsRob GronkowskiDwayne AllenJacob Hollister 
New Orleans SaintsCoby FleenerJosh HillMichael Hoomanawanui 
New York GiantsEvan EngramRhett EllisonJerell Adams 
New York JetsAustin Seferian-JenkinsEric Tomlinson  
Oakland RaidersJared CookLee SmithClive Walford 
Philadelphia EaglesZach ErtzBrent CelekTrey Burton 
Pittsburgh SteelersJesse JamesVance McDonaldXavier Grimble 
San Francisco 49ersGeorge KittleGarrett CelekLogan Paulsen 
Seattle SeahawksJimmy GrahamLuke WillsonNick Vannett 
Tampa Bay BuccaneersCameron BrateO.J. HowardAntony Auclair 
Tennessee TitansDelanie WalkerPhillip SupernawJonnu Smith 
Washington RedskinsJordan ReedVernon DavisNiles Paul 

David Njoku, CLE- I have written about Njoku on more than one occasion this season and I will continue to do so until the Browns realize he is their best receiving option.  In Week 5 Njoku caught three passes for 48 yards and a touchdown.  The touchdown was his third over the last four weeks in a passing offense that has been absolutely dreadful this season. There is hope however as the Browns are making yet another change at QB and will be starting Kevin Hogan in Week 6 who wasn't half bad in Week 5, throwing for 194 yards and two touchdowns against the Jets.