Saints vs. Chiefs Predictions, Picks & Odds: Monday Night Football, 10/7

After taking on the Atlanta Falcons on Sunday Night Football just two weeks ago, the Kansas City Chiefs are back in prime time against another NFC South team - the New Orleans Saints - on Monday Night Football. To get you prepared for the matchup, we’ve provided you with our best Saints vs. Chiefs predictions.
Better yet, we even have a guaranteed $200 DraftKings Sportsbook bonus for you following the best bet from our Saints vs. Chiefs picks, which can be claimed using any betting market, not just the Saints vs. Chiefs odds!
Saints vs. Chiefs Predictions for Monday Night Football, NFL Week 5
The Chiefs are off to a 4-0 start to their campaign in the quest to become the first team in NFL history to win three straight Super Bowls. However, it hasn’t been the cleanest undefeated record we’ve ever seen, and injuries are also becoming a major factor.
After the Saints 2-0 start to the season by combined score of 91-29, they looked like absolute world-beaters and a true Super Bowl contender. Since then, they’ve dropped two straight, but they’ve only been by a combined five points.
So, what’s the best way to approach Saints vs. Chiefs predictions? Well, our best bet is going to be focused on a prop market, which we’ll break down for you coming up.
New Orleans Saints: Building On Derek Carr
Before we get into the best bet from our Saints vs. Chiefs picks, it has become increasingly difficult to get a good read on New Orleans. After their offensive explosions in Week 1 and 2, they struggled to score at all against the Philadelphia Eagles and found some middle ground last week with 24 points.
Their defense has remained solid, which is why if anything, we’re expecting a rather low-scoring MNF game. After all, prime time unders have hit at a great clip the past few years now. However, we’re going to be focusing on just the Saints side of things, but first, more about the Chiefs as to why that is.
Kansas City Chiefs: Finding Positives In A Loss
As we previously stated, injuries are already taking a significant toll on the back-to-back Super Bowl champs, and it’s only Week 5. Most teams don’t generally want an early bye week, but KC is one that may have preferred to have it with this first set of them.
After recently losing RB Isaiah Pacheco for quite some time, they will now be without WR Rashee Rice for at least four weeks after being placed on IR. Along with the fact that TE Travis Kelce is having his worst season ever, the Chiefs are relying even more on their defense than they did last season where they largely carried things.
Saints vs. Chiefs Odds, Spreads, Total & Betting Lines
Kansas City’s defense is a perfect lead into the best bet from our Saints vs. Chiefs predictions, but quickly, the latest Saints vs. Chiefs odds at DraftKings Sportsbook:
- Point Spread: New Orleans Saints +5.5 (-105) vs. Kansas City Chiefs -5.5 (-115)
- Money Line: New Orleans Saints (+215) vs. Kansas City Chiefs (-265)
- Game Total (Over/Under): Over 43.5 (-112) vs. Under 43.5 (-108)
Saints vs. Chiefs Predictions: New Orleans Team Total Under 19.5 Points (-120 at DraftKings Sportsbook)
If you prefer sticking with standard markets for your Saints vs. Chiefs picks, we’d be comfortable with the game under as well, but we prefer to isolate New Orleans. It also helps that DraftKings provides several team totals to choose from rather than only the 18.5 points available at most other sportsbooks.
Regardless, we simply don’t expect the Saints to light up the scoreboard in prime time. They were able to hit over this total last week, but scored just 12 points the week prior. It’s also important to note that their 24 points last week came against an Atlanta Falcons defense that we recently saw allow 30 points on Thursday Night Football.
Even without that fact, the Chiefs defense has simply been the stronger unit the past two seasons at least. Superstar QB Patrick Mahomes would admit that as well, as he’s openly discussed the offense not firing on all cylinders.
All that is perfectly illustrated by the fact that KC has gotten off to a 4-0 start while scoring more than 22 points themselves just once. That means that they’ve been victorious by holding their opponents to low totals, as they’ve allowed more than 20 points just once. Most recently, they’ve allowed just 10 and 17 points, and those were both road games.
As many fans would agree, Arrowhead Stadium is one of the most difficult places for opponents to play, which should only help KC in a primetime game. Therefore, we’re locking in the best bet from our Saints vs. Chiefs predictions on the New Orleans team total under 19.5 points (-120 at DraftKings Sportsbook).
Saints vs. Chiefs Injury Report & Latest News
Before targeting any market of the Saints vs. Chiefs odds, make sure that you also have the latest injury report, which is following Friday’s practice:
- Taysom Hill - DNP
- Cesar Ruiz - DNP
- Shane Lemieux - DNP
- Lucas Patrick - DNP
- Payton Turner - DNP
- Willie Gay Jr. - DNP
- Alvin Kamara - LP
- Taliese Fuaga - LP
- Bryan Bresee - LP
- Demario Davis - LP
- Mecole Hardman - DNP
- Kareem Hunt - LP
- Clyde Edwards-Helaire - LP
- Mike Danna - LP
How To Bet On Saints vs. Chiefs At DraftKings Sportsbook & Claim Your $200 Bonus
If you’d like to tail our Saints vs. Chiefs predictions, or even if you’d like to fade our pick, here’s how you can do so while claiming a guaranteed $200 DraftKings bonus:
- Sign up here for a new DraftKings account
- Make a first-time deposit of $5 or more
- Place a wager of $5+ on any sporting event
- Receive $200 in bonus bets, even if it loses!
As you can see, that’s 40 times your first bet amount guaranteed, and you won’t even need to have a DraftKings promo code! That’s as long as you become a new member through us, so feel free to use any link or banner in this article.
Player News
Dolphins signed No. 13 overall pick DT Kenneth Grant to a four-year contract.
ESPN’s Jeremy Fowler reports that Grant will sign his contract today. The former Michigan defensive tackle is expected to fill a major void left by Christian Wilkins, who left for the Raiders in the 2024 offseason. Grant totaled 32 tackles, three sacks, and seven TFLs in his final season at Michigan and excelled at stopping the run while also generating 27 pressures in his final season, per PFF.
Beat reporter John Hendrix reports that free agent WR Donovan Peoples-Jones is among the 16 players that the Saints will host for their rookie minicamp.
Peoples-Jones last played regular season snaps with the Lions back in 2023, when he caught 13-of-24 targets for 155 yards. He is highly unlikely to return to fantasy relevance at this point but could perhaps sign on as a special teams contributor.
Titans signed fourth-round pick WR Elic Ayomanor to a four-year contract.
Ayomanor will now begin learning behind Calvin Ridley. Although Ayomanor is unlikely to find a meaningful role in year one, dynasty managers should note his status as training camp gets underway this summer. The former Stanford receiver flashed big-play ability in his two college seasons.
Buccaneers signed seventh-round pick WR Tez Johnson to a four-year contract.
Johnson will serve as a rotational deep-threat option for Baker Mayfield. His thin frame (5'10/154) simply does not lend itself to the repeated hits one incurs in a full-time role. Johnson did earn 100-plus targets in his two seasons at Oregon, though. His big-play style make him a better fit in best ball for now, pending any major on-field breakthroughs.
Giants waived DT Casey Rogers.
Rogers was a 2024 undrafted free agent and logged 33 defensive snaps for the Giants in his rookie season. He is credited with zero tackles and/or sacks. He may find his way onto another roster as a practice squad option.
Vikings signed third-round pick WR Tai Felton to a four-year contract.
Felton is quietly in play to challenge Vikings No. 3 WR Jalen Nailor in training camp. Nailor (5'11/190) caught 28-of-42 targets for 414 yards and six touchdowns in his first season as a starter last year, with the latter category buoying his fantasy productivity. Felton (6'1/183), meanwhile, caught 96-of-143 targets for 1,119 yards and nine touchdowns while averaging 2.32 yards per route run in his final college season. Fantasy managers should monitor Felton’s training camp reports this summer, as he could have a matchup-based WR5 role if everything falls into place.