It’s Sunday, so you know what that means! It’s time to take a look at the interleague matchups for the upcoming week and determine how it will affect our fantasy lineups. Which players are gaining or losing fantasy value this week? You’ll find that and more here at Fantasy Alarm!
This week, we are treated to a couple of AL East teams heading to NL stadiums, and two other interesting interleague showdowns. Without further ado, let's jump in and see what’s on tap for the week ahead!
Orioles @ Nationals (5/21-5/23)
Baltimore loses the designated hitter again and pretty much what we’ve seen this year is that DJ Stewart is going to be the odd man out. He’s made just one start in a National League park this year, and that was back on April 20th. Trey Mancini will play first base, with Ryan Mountcastle , Cedric Mullins and Austin Hays holding down the three outfield spots. If Anthony Santander were to be able to return to action, that could make things more interesting.
Winners: No Major Winners
Losers: DJ Stewart
Red Sox @ Phillies (5/21-5/23)
With Boston losing the designated hitter, JD Martinez will slide into the left field spot, and then Boston will likely look to attack the opposing pitchers. In two games earlier this year in a National League stadium, Martinez played left field, and then Hunter Renfroe got the start against a lefty, while Alex Verdugo started against a right-hander. Barring injuries and any mid-week postponements, Philadelphia is slated to trot out Aaron Nola , Chase Anderson and Zack Wheeler . Three right-handers could potentially mean a full weekend for Verdugo, with guys like Franchy Cordero and Renfroe on the outside looking in.
Winners: Alex Verdugo
Losers: Hunter Renfroe , Franchy Cordero
Brewers @ Royals (5/18-5/19)
We’ll finally get to see a Milwaukee lineup utilizing the designated hitter, and boy do they need it. Daniel Vogelbach seems like the obvious choice to serve as the team’s DH, but in this two-game set, Kansas City is slated to have one lefty make a start, and Vogelbach normally sits against southpaws. So, Vogelbach likely makes one start at DH, and then Milwaukee could opt for a catcher to serve as the DH in the other game (perhaps Manny Piña , as he’s solid against lefties), or maybe one of their outfielders (like Tyrone Taylor). I wouldn’t say anyone wins or loses, as this is a bad, bad offense.
Winners: No Major Winners
Losers: No Major Losers
Mariners @ Padres (5/21-5/23)
The Mariners have been without the designated hitter twice this year, and its primary DH, Ty France , found himself in the lineup both contests. However, France is injured and on the 10-day injured list, so he’s out of the equation. The team needs Mitch Haniger ’s bat in the lineup, so he needs to be in the outfield, alongside Jarred Kelenic and Kyle Lewis. The injury to France, and Evan White for that fact, really clears things up, as Seattle will likely continue to rotate their catchers, and have their starters be José Marmolejos , Dylan Moore , Kyle Seager , J.P. Crawford and the three aforementioned outfielders. However, they do have to face Chris Paddack , Dinelson Lamet and Yu Darvish , so that’s not a great draw.
Winners: The aforementioned starters
Losers: None
Player News
Tanner Scott struck out three in a scoreless ninth to get a save Wednesday versus the Rockies.
Scott did allow a hit, so it’s up to others to determine whether he struck out the side. Whether he did or not, it’s as good as Scott has looked as a Dodger, and he threw 11-of-11 pitches for strikes; impressive regardless, but especially for a pitcher who sometimes has issues with control. Scott should continue to see plenty of save chances for this loaded Dodgers’ club.
Freddie Freeman doubled and homered in the Dodgers’ win over the Rockies on Monday.
Michael Toglia hit a grand slam, but the Rockies lost Monday to the Dodgers.
Shohei Ohtani went 2-for-5 with a homer and two RBI in an 8-7 win Saturday over the Rockies.
Bobby Miller allowed six earned runs over three innings in a no-decision vs. the Rockies on Wednesday.
Miller was making his first start of the 2025 season, and it’s hard to fathom it went how he wanted it to. Fortunately for him and the fantasy managers who streamed him against the lowly Rockies, he received seven runs of support while he was in, so he wasn’t charged with a loss. He did strike out seven, but he allowed eight hits as well; two of those hits leaving the ballpark. The biggest blow was a grand slam by Michael Toglia, buth e pitched shakily — to put it nicely — for most of the contest. There’s no start scheduled, but if Miller does get another outing, it’ll likely come against the Cubs on Wednesday.
Germán Márquez recorded just two outs while being charged for seven runs in a loss to the Dodgers on Wednesday.
Márquez was handed a 1-0 lead going into his first and final inning, and it lasted just four pitches before Shohei Ohtani smashed a solo homer. He gave up another homer two batters later to Freddie Freeman, and the 30-year-old allowed four more hits and the same amount of runs before exiting. It’s hard to imagine that anyone used Márquez that didn’t have to Wednesday, but for those who did: whoops. He’ll be on the mound next week against the Royals and look to lower and unsightly 8.27 ERA.