Arizona vs. Duke Predictions, Picks & Odds: March Madness Sweet 16
The Sweet 16 is ready for an exciting matchup between the top-seeded Duke Blue Devils and the fourth-seeded Arizona Wildcats in the East Region. Earlier this season, Duke faced Arizona and won decisively with a score of 69-55 in Tucson.
Now, the pressure is on, and Arizona has a chance to get back at Duke for that loss, as a spot in the Elite Eight is at stake. Let’s dive into this Sweet 16 matchup with our expert Arizona vs. Duke picks, odds, and the best bets.
Arizona vs. Duke Predictions For March Madness Sweet 16, 3/27
Duke has proven why they are the number one seed by defeating Baylor 89-66, thanks to an impressive game from Tyrese Proctor and a strong overall performance from standout freshman Cooper Flagg.
Meanwhile, Arizona had to rally in the second half to beat Oregon 87-83, with Caleb Love scoring 29 points. Will Duke maintain its winning streak, or can Arizona turn the tables in Newark? You may be surprised by what our Arizona vs. Duke predictions see taking place.
Arizona Wildcats: Their Toughest Test Yet
Arizona has had some impressive moments this season, but their next challenge is the toughest one yet. Their strong offense, averaging 82.0 points per game, can easily overpower teams, but their defense, allowing 72.1 points per game, has caused some close games.
Caleb Love, scoring 19.5 points per game, has been outstanding in the tournament, but the team struggles with turnovers. To succeed against top-tier teams, Arizona needs to minimize their mistakes and show they can handle tough, competitive games.
With their depth and solid rebounding, averaging 36.4 rebounds per game, they have a shot, but this is the moment to either step up their performance or fall behind against the elite.
Duke Blue Devils: Showcasing Their Dominance
Duke has dominated their opponents with a powerful mix of high-scoring offense (82.7 PPG) and strong defense (61.9 PPG allowed). Tyrese Proctor has been exceptional, averaging 22.0 PPG, and the Blue Devils' shooting efficiency (48.8 FG%) makes them extremely difficult to defend against.
Their impressive defense, which ranks in the top 10 in several categories, has stifled teams throughout the season. This tournament is their opportunity to showcase their strength—showing they are not just contenders for the title but the team everyone else needs to watch out for.
With their size, shooting ability, and disciplined defense, Duke aims to assert their dominance and clearly demonstrate their championship goals.
How To Watch The Sweet 16 Of March Madness 2025
The thrilling Sweet 16 of the NCAA Tournament kicks off today, featuring exciting matchups and unforgettable moments.
To keep up with all the action, including our Arizona vs. Duke predictions for the game and other contests happening today, there are plenty of viewing options to choose from:
TV Channels
- CBS, TBS
Streaming Options
- March Madness Live, YouTube TV, Hulu + Live TV, Sling TV
Arizona vs. Duke Game Details
- Date: Thursday, March 27, 2025
- Location: Prudential Center, Newark, NJ
- Start Time: 9:39 PM ET
- TV: CBS
Arizona vs. Duke Odds, Spreads, Total & Betting Lines
Bet365 Sportsbook quickly published the Arizona vs. Duke odds and lines for the Sweet 16 game as soon as the matchup was announced. Here are the latest numbers:
- Arizona Wildcats (+390) vs. Duke Blue Devils (-525)
- Spread: Arizona +9.5 (-110) vs. Duke -9.5 (-110)
- Game Total: Over 153.5 (-110) vs. Under 153.5 (-110)
Arizona vs. Duke Spread Pick: Wildcats +9.5 (-110 at Bet365)
When looking to make Arizona vs. Duke picks, Arizona +9.5 (-110 at Bet365) seems like a lot of extra points to ignore. Even though Duke has been strong in the tournament, this matchup is their biggest challenge so far. Arizona is not the same team Duke faced back in November, especially with Caleb Love stepping up.
Love has been on fire, scoring an average of 19.5 points per game in the tournament and hitting an impressive 63.6% of his three-point shots. He can be inconsistent, but when he’s on, he can really change the flow of a game.
Arizona’s offense, which scores 82.0 points per game, along with their strong rebounding (36.4 rebounds per game, ranked 15th in the nation), should keep them in the game, even against Duke’s tough defense.
The Blue Devils are great defensively, allowing only 61.9 points per game, but Arizona has the talent to fight back. This doesn’t mean Duke won’t win, but giving 9.5 points to a seasoned Wildcats team that’s hitting its stride is a lot. So, our Arizona vs. Duke predictions will pick the Wildcats to cover the +9.5-point spread (-110 at Bet365).
Arizona vs. Duke Injury Report & Starting Lineup
Arizona Wildcats Injury Report
- M. Krivas – C: Out – Lower Leg
Arizona Wildcats Projected Starters
- C. Love – 19.5 PPG, 8.0 RPG
- J. Bradley – 15.5 PPG, 4.5 RPG
- K. Lewis – 11.0 PPG, 5.5 RPG
- A. Dell'Orso – 10.5 PPG, 3.0 APG
- T. Townsend – 9.0 PPG, 5.5 RPG
Duke Blue Devils Injury Report
- M. Brown – F: Questionable – Shoulder
Duke Blue Devils Projected Starters
- T. Proctor – 22.0 PPG, 3.5 APG
- C. Flagg – 16.0 PPG, 8.0 RPG
- K. Maluach – 9.5 PPG, 5.0 RPG
- C. Foster – 9.0 PPG, 2.0 APG
- K. Knueppel – 9.0 PPG, 2.5 APG
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Player News
Andrés Chaparro (oblique) will begin his rehab assignment this week.
The 26-year-old was put on the IL with an oblique strain back on March 26th, so it’s been almost two months since he’s played in a game. He will take some time to work his way back into game shape, but he also hit .215/.280/.413 over 33 games with the Nationals last year, so there is no guarantee he gets another chance right away.
Guardians hired Corey Kluber as a special assistant with a focus on pitching development.
The former Guardians ace will be primarily responsible for helping the pitching staff; although, there is little information on what capacity. The Guardians already have one of the most experienced and respected pitching coaches in baseball in Carl Willis, but perhaps Kluber can help with gameplans and the mental side of the game. “I probably experienced pretty close to a full spectrum of things in a career. I wasn’t a very good minor-leaguer, figured out some stuff, and still had to develop at this stage. … It’s having a lot of different types of experiences to build on. Hopefully, it presents opportunities to help guys with a lot of different things.”
Andruw Monasterio is playing shortstop and batting eighth for the Brewers on Wednesday.
The Brewers are facing right-hander Gavin Williams, and Monasterio is still getting the start over Joey Ortiz. Monasterio has started the last three games, two at shortstop and one at third base, while both Ortiz and Caleb Durbin continue to struggle. Monasterio hit .250 with four home runs and eight steals in 30 games at Triple-A this season.
Colby Thomas went 4-for-6 with three RBI and two runs scored for Triple-A Las Vegas on Tuesday.
Thomas and his fellow Triple-A outfielder Denzel Clarke continue to put on a show in Triple-A, with Clarke also driving in three runs in this game. Clarke is on the 40-man roster while Thomas is not, but Thomas is slashing .314/.372/.551 in 37 games this season with eight home runs and two steals. The Athletics may need to find at-bats for both of these guys at some point over the summer.
Mariners C prospect Harry Ford went 4-for-4 with a home run, three RBIs, and three runs scored for Triple-A Tacoma on Tuesday.
Ford is now hitting .292 with an .851 OPS, two home runs, and 12 RBI on the season. There is no spot for the 22-year-old in Seattle, but it’s nice to see him begin to find his power stroke a bit.
Dalton Rushing went 2-for-5 with a walk, a home run, three RBI, and two runs scored for Triple-A Oklahoma City on Tuesday.
The 24-year-old is now hitting .308 with a .938 OPS, five home runs, and 17 RBI on the season. Rushing is primarily a catcher but has also played nine games at first base and two games in left field this season as the Dodgers look to create any path for him to get at-bats with the big league club.