The Sweet 16 is ready for an exciting matchup between the top-seeded Duke Blue Devils and the fourth-seeded Arizona Wildcats in the East Region. Earlier this season, Duke faced Arizona and won decisively with a score of 69-55 in Tucson.

Now, the pressure is on, and Arizona has a chance to get back at Duke for that loss, as a spot in the Elite Eight is at stake. Let’s dive into this Sweet 16 matchup with our expert Arizona vs. Duke picks, odds, and the best bets.

 

 

 

Arizona vs. Duke Predictions For March Madness Sweet 16, 3/27

Duke has proven why they are the number one seed by defeating Baylor 89-66, thanks to an impressive game from Tyrese Proctor and a strong overall performance from standout freshman Cooper Flagg.

Meanwhile, Arizona had to rally in the second half to beat Oregon 87-83, with Caleb Love scoring 29 points. Will Duke maintain its winning streak, or can Arizona turn the tables in Newark? You may be surprised by what our Arizona vs. Duke predictions see taking place.

 

 

 

Arizona Wildcats: Their Toughest Test Yet

Arizona has had some impressive moments this season, but their next challenge is the toughest one yet. Their strong offense, averaging 82.0 points per game, can easily overpower teams, but their defense, allowing 72.1 points per game, has caused some close games.

Caleb Love, scoring 19.5 points per game, has been outstanding in the tournament, but the team struggles with turnovers. To succeed against top-tier teams, Arizona needs to minimize their mistakes and show they can handle tough, competitive games. 

With their depth and solid rebounding, averaging 36.4 rebounds per game, they have a shot, but this is the moment to either step up their performance or fall behind against the elite.

 

 

 

Duke Blue Devils: Showcasing Their Dominance

Duke has dominated their opponents with a powerful mix of high-scoring offense (82.7 PPG) and strong defense (61.9 PPG allowed). Tyrese Proctor has been exceptional, averaging 22.0 PPG, and the Blue Devils' shooting efficiency (48.8 FG%) makes them extremely difficult to defend against.

Their impressive defense, which ranks in the top 10 in several categories, has stifled teams throughout the season. This tournament is their opportunity to showcase their strength—showing they are not just contenders for the title but the team everyone else needs to watch out for.

With their size, shooting ability, and disciplined defense, Duke aims to assert their dominance and clearly demonstrate their championship goals.

 

 

 

How To Watch The Sweet 16 Of March Madness 2025

The thrilling Sweet 16 of the NCAA Tournament kicks off today, featuring exciting matchups and unforgettable moments.

To keep up with all the action, including our Arizona vs. Duke predictions for the game and other contests happening today, there are plenty of viewing options to choose from:

TV Channels

  • CBS, TBS

Streaming Options

  • March Madness Live, YouTube TV, Hulu + Live TV, Sling TV

Arizona vs. Duke Game Details

  • Date: Thursday, March 27, 2025
  • Location: Prudential Center, Newark, NJ
  • Start Time: 9:39 PM ET
  • TV: CBS

 

 

 

Arizona vs. Duke Odds, Spreads, Total & Betting Lines

Bet365 Sportsbook quickly published the Arizona vs. Duke odds and lines for the Sweet 16 game as soon as the matchup was announced. Here are the latest numbers:

  • Arizona Wildcats (+390) vs. Duke Blue Devils (-525)
    • Spread: Arizona +9.5 (-110) vs. Duke -9.5 (-110)
    • Game Total: Over 153.5 (-110) vs. Under 153.5 (-110)

 

 

 

Arizona vs. Duke Spread Pick: Wildcats +9.5 (-110 at Bet365)

When looking to make Arizona vs. Duke picks, Arizona +9.5 (-110 at Bet365) seems like a lot of extra points to ignore. Even though Duke has been strong in the tournament, this matchup is their biggest challenge so far. Arizona is not the same team Duke faced back in November, especially with Caleb Love stepping up.

Love has been on fire, scoring an average of 19.5 points per game in the tournament and hitting an impressive 63.6% of his three-point shots. He can be inconsistent, but when he’s on, he can really change the flow of a game.

Arizona’s offense, which scores 82.0 points per game, along with their strong rebounding (36.4 rebounds per game, ranked 15th in the nation), should keep them in the game, even against Duke’s tough defense.

The Blue Devils are great defensively, allowing only 61.9 points per game, but Arizona has the talent to fight back. This doesn’t mean Duke won’t win, but giving 9.5 points to a seasoned Wildcats team that’s hitting its stride is a lot. So, our Arizona vs. Duke predictions will pick the Wildcats to cover the +9.5-point spread (-110 at Bet365).

 

 

 

Arizona vs. Duke Injury Report & Starting Lineup

Arizona Wildcats Injury Report

  • M. Krivas – C: Out – Lower Leg

Arizona Wildcats Projected Starters

  • C. Love – 19.5 PPG, 8.0 RPG
  • J. Bradley – 15.5 PPG, 4.5 RPG
  • K. Lewis – 11.0 PPG, 5.5 RPG
  • A. Dell'Orso – 10.5 PPG, 3.0 APG
  • T. Townsend – 9.0 PPG, 5.5 RPG

Duke Blue Devils Injury Report

  • M. Brown – F: Questionable – Shoulder

Duke Blue Devils Projected Starters

  • T. Proctor – 22.0 PPG, 3.5 APG
  • C. Flagg – 16.0 PPG, 8.0 RPG
  • K. Maluach – 9.5 PPG, 5.0 RPG
  • C. Foster – 9.0 PPG, 2.0 APG
  • K. Knueppel – 9.0 PPG, 2.5 APG

 

 

 

How To Bet On Arizona vs. Duke At Bet365 & Claim $150 In Bonus Bets

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