The theme of Thursday Night Football this season has been division rivalries, and that’s exactly what we have to kick off Week 15 with the San Francisco 49ers hosting the Los Angeles Rams. These are two teams that have been to Super Bowls rather recently, and we’ve got our Rams vs. 49ers predictions for you below.

Of course, that also means a best bet from our Rams vs. 49ers picks, which we’ll pair with a generous, multi-part FanDuel Sportsbook sign up bonus!

 

 

 

Rams vs. 49ers Predictions For Thursday Night Football, NFL Week 15

Per usual, the Rams and 49ers were in the late window of Sunday’s slate this past weekend, and they were each a part of two of the most polarizing games of the Week 14 action. However, they came in completely opposite fashions.

While LA was in an absolutely epic back-and-forth shootout with the Buffalo Bills that was one of the most fun games of the entire season to watch, San Francisco was a part of an absolutely massive blowout, crushing the Chicago Bears. So, we aren’t too surprised to see the Rams vs. 49ers odds having this matchup projected to be a close matchup.

LA was able to pull off the upset when these teams met back in Week 3, so can they do it again on the road? That’s what the best bet from our Rams vs. 49ers predictions is here to help answer after working through each team!

 

 

 

Los Angeles Rams: Rolling On With Momentum

Along with LA upsetting the 49ers in Week 3, they also just upset arguably the hottest and best teams in the NFL - the Bills. With how wide open the NFC West is right now - just two of the four teams have winning records - those two upsets could prove to be the deciding factor in either a division title or playoff berth in general.

While upsetting the 49ers right now doesn’t seem completely crazy, keep in mind, when they did so at the beginning of the season, San Francisco was still projected to win the entire NFC. LA should have confidence that they can do so again with their most recent win, and while they’ll be on the road this time, it’s just a short trip up the 405.

 

 

 

San Francisco 49ers: Building Positivity

Like the Rams, the 49ers also need to build off their recent win this past weekend but it’s from a different perspective. Rather than exceeding expectations like LA, San Francisco is performing well below them. Speaking of being below, they are at the very bottom of the NFC West!

Although it’s due to tiebreaker, seeing the expected NFC representative for the Super Bowl with a losing record is not what fans expected this season. While much of it has been due to very significant injuries, they were already not looking the part prior to those concerns. There’s still time to turn things around, and once the playoffs start, it’s an entirely new season.

 

 

 

Rams vs. 49ers Odds, Spreads, Total & Betting Lines

We noted that the Rams vs. 49ers odds have this NFC West rivalry projected to be a close one, and you can see the latest lines at FanDuel Sportsbook here:

 

 

 

Rams vs. 49ers Best Bet: Over 48.5 Points (-114 at FanDuel Sportsbook)

With such a storied matchup, there is plenty of recent history to pull from for Thursday Night Football this week, which also means trends to find. Before we dive into the focus of our Rams vs. 49ers predictions, it’s worth sharing some interesting ones.

Over the past 10 meetings between these teams, the Rams are just 3-7 against the spread. However, all three of those covers have been in each of the three most recent matchups, and with how much these teams have changed the past couple of seasons, perhaps the trend to consider for your Rams vs. 49ers picks.

Regardless, we’re going to focus on another one. That would be the fact that each of the last four times these NFC West rivals have met, they have gone over the total. Prior to this season, prime time unders had been a great trend to back, but that has since changed as offenses continue to get more and more explosive.

Look back at just last Thursday Night Football where we had 65 total points scored. Admittedly, the totals in the last four meetings have been lower than this week’s, but even in their Week 3 matchup, there were 51 total points scored.

That’s without even mentioning how both of these teams lit up the scoreboard just a few days prior to this Thursday Night Football clash. The 49ers put up 38 points, and if it wasn’t a blowout early, they could have kept pouring it on. Similarly, the Rams put up 44 points on one of the best teams in the NFL this past Sunday.

Along with the fact that LA also allowed 42 points in that game, we should have no problem with over 48.5 points (-116 at FanDuel Sportsbook) as the best bet from our Rams vs. 49ers predictions.

 

 

 

Rams vs. 49ers Injury Report & Latest News

With the 49ers involved in Thursday Night Football, injuries are arguably the most significant piece of news. From losing RB Christian McCaffrey for the year, not to mention WR Brandon Aiyuk, there are also things to monitor for TNF specifically. We saw QB Brock Purdy exit last Sunday’s game, and for all injury updates, keep track of the Fantasy Alarm NFL injury report.

 

 

 

How To Bet On Rams vs. 49ers At FanDuel Sportsbook & Claim Your $150+ Bonus

Let’s add some value to any Rams vs. 49ers picks by taking you through the current multi-gifted FanDuel sign up bonus:

  1. Sign up here for a new FanDuel account
  2. Make an initial deposit of at least $10
  3. Wager at least $5 on any matchup
  4. Receive $150 in bonus bets as long as it wins

That’s just the first part, and while a chance for a 30x boost is already fantastic, the other portion is guaranteed! You’ll also receive three free months of NBA League Pass to enjoy more sports than just TNF! Lock it in with no FanDuel promo code when you register here today!